HLA-DR5: Causes & Reasons

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Possible Causes for HLA-DR5

Geographic Tongue

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.com]

[…] combination with conditions such as chronic granulomatous disease, fissured tongue and psoriasis. [4], [5] Unknown causes, allergic rhinitis, asthma, human leukocyte antigens (HLA-DR5 [njgp.org]

HLADRW6, and HLA-CW6), congenital condition, atopy, inflammation, and polygenic mode are postulated causes. [3], [6], [7], [8], [9], [10] Usually the condition is asymptomatic [njgp.org]

Juvenile Seronegative Polyarthritis

ICD.Codes ICD-10-CM (2016) Chapter 13 Section M05-M14 Code M08.3 BILLABLE Billable Code Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis. | ICD-10 from 2011 - 2016 M08.3 is a billable ICD code used to specify a diagnosis of juvenile rheumatoid polyarthritis[…] [icd.codes]

Chronic Fibrous Thyroiditis

[…] euthyroidism so must monitor thyroid function ( Clin Endocrinol (Oxf) 2009;71:451 ) No female predominance in children with Down syndrome ( Horm Res 2008;70:278 ) Associated with HLA-DR5 [pathologyoutlines.com]

HLA-DR4, HLA-DR5) in Caucasian populations • Elevated iodine intake (at least 0.5 mg/day) • Selenium deficiency • Amiodarone • Exposure to ionizing radiation • Turner syndrome [clinicaladvisor.com]

There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [humpath.com]

Thyroiditis

Commonly Associated Conditions Postpartum thyroiditis: family history of autoimmune thyroid disease; HLA-DRB, HLA-DR4, and HLA-DR5 -- To view the remaining sections of this [unboundmedicine.com]

The goitrous form (rather than atrophic) is associated with HLA-DR5. [patient.info]

Allergic Bronchopulmonary Aspergillosis

Although not familial in most patients, presentation of Asp f1 antigen is restricted to specific major histocompatability complex class II molecules, HLA-DR2 and HLA-DR5. [ncbi.nlm.nih.gov]

Individuals with the HLA DR2 and HLA DR5 haplotypes appear to be predisposed to ABPA. Procedure see individual test information [viracoribt.com]

Salivary Gland Disorder

A sicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosis. Lancet 2: 466 - 468. [doi.org]

[…] infiltration, sarcoid, amyloid, tuberculosis, leukemia, and lymphoma, but now also a Sjögren's syndrome—like disorder related to the human immunodeficiency virus and linked to HLA-DR5 [nejm.org]

A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DR5. [doi.org]

Riedel Thyroiditis

[…] most common cause of hypothyroidism; an autoimmune disorder (thyroid peroxydase, antithyroglobulin antibodies) Associated with HLA-DR5. [memorize.com]

• There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [de.slideshare.net]

Fissured Tongue

Associations with human leukocyte antigens (HLA)-DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [7] BMG has also been linked to allergies. [jisppd.com]

Some have reported links with various human leukocyte antigens, such as increased incidence of HLA-DR5, HLA-DRW6 and HLA-Cw6 and decreased incidence in HLA-B51. [10] Vitamin [en.wikipedia.org]

Lymphocytic Interstitial Pneumonia

A host immune response associated with HLA-DR5. Ann Intern Med 1990;112:3-10. Contributed by Sonya Arnold, MD and Susan Hasegawa, MD, PhD [path.upmc.edu]

Patients positive for HLA-DR5 and HLA-DR6 alleles are predisposed to developing a diffuse visceral lymphocytosis syndrome with LIP. [emedicine.com]

Autosomal Recessive Anterior Segment Dysgenesis

HLA-A3 (35.5%), A4 (41%), B5 (41.2%), DR5 (47%) and DR7 (47%) were the most frequent antigenic types in our patients. [emro.who.int]

Frequencies of different HLA class I antigens in our patients did not differ significantly from those of the general population of Khorasan province (chi-squared P > 0.05) [emro.who.int]

Idiopathic Hypersomnia

Despite some reports that suggest an increased frequency of human leukocyte antigen (HLA) Cw2 and HLA DR5 in idiopathic hypersomnia, [ 19 ] HLA typing is of no help in the [beatcfsandfms.org]

[…] greater than the 5.7% found in controls ( P < 0.05), and an association with HLA-DR11, a subtype of DR5, in 42.1% of patients but in only 26% of controls. [beatcfsandfms.org]

In the author's population of 32 probands, an increased frequency of HLA-Cw2 and DR11 was not present, but there was a significant increase of DQ3 ( P < 0.04). [beatcfsandfms.org]

Sjögren Syndrome

According to Israeli research ,HLA-DR5 is associated with S.S in Israelipersons.Possible disease triggersViruses are viable candidates as environmental triggers, uncertain [slideshare.net]

[…] with HLA-DR3 and HLA-DR5. [13] These HLA associations appear restricted to individuals with Sjögren syndrome who have antibodies to the antigens SSA and SSB rather than to [emedicine.com]

Some evidence indicates that the true association of Sjögren syndromemay be with HLA-DQA1. [slideshare.net]

Chronic Thyroiditis

[…] inhibitory signal to T cells, so reduced functioning is associated with increased T-lymphocyte activity. [16] [17] A family history of thyroid disorders is common, with the HLA-DR5 [en.wikipedia.org]

Silent Thyroiditis

There may be an inherited component (there is a high frequency of both HLA-DR3 and HLA-DR5 in patients with this type of thyroiditis) and/or an autoimmune component (patients [pathologystudent.com]

Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: Evidence supporting an autoimmune pathogenesis. J. Clin. [link.springer.com]

Folliculotropic Mycosis Fungoides

HLA-DR5 and DQB1*03 class II alleles are associated with cutaneous T-cell lymphoma. J Invest Dermatol. 1996; 107 :373–6. [ PubMed ] [ Google Scholar ] 14. [ncbi.nlm.nih.gov]

Hashitoxicosis

Genetic predisposition :HLA-DR3 & DR5 Immune causes Immune Regulatory Genes [CTLA4, PTPN22] cytotoxic T lymphocyte–associated antigen-4 (CTLA4) protein tyrosine phosphatase [ilovepathology.com]

(goitrous form), HLA-DR3 (atrophic form) May coexist with SLE, rheumatoid arthritis, Sjögren syndrome, pernicious anemia, type 2 diabetes, Graves disease, chronic active [pathologyoutlines.com]

Glossitis

Associations with human leukocyte antigen HLA DR5, HLA DRW6 and HLA Cw6 have been reported. Maintaining a good oral hygiene may prevent glossitis. [symptoma.com]

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.medscape.com]

Familial Thyroid Dyshormonogenesis Type 1

Autoimmune desctruction of thyroid gland Assoc: HLA-DR5 Most common cause of hypothyroid when sufficient iodine Presents Initial: hyp er thyroidism Destroy follicles TH stored [alancam.com]

Polyarticular Juvenile Idiopathic Arthritis

DR5 (HLA-DR5) test puts patients at increased risk for developing uveitis. [eyewiki.aao.org]

[…] association HLA DRB1*0401, 0404, 0101 in Caucasians EOPA: HLA-A2, -DR5, -DR8, - DPB1*0201. [arthritis-research.biomedcentral.com]

It appears to have association with HLA alleles other than B27 (e.g. HLA-DR5). [pathophys.org]

Hashimoto Thyroiditis

[…] euthyroidism so must monitor thyroid function (Clin Endocrinol (Oxf) 2009;71:451) No female predominance in children with Down syndrome (Horm Res 2008;70:278) Associated with HLA-DR5 [pathologyoutlines.com]

The goitrous form (rather than atrophic) is associated with HLA-DR5. Twin studies indicate that there is about 70% genetic contribution to autoimmune thyroid disease[3]. [patient.info]

[…] inhibitory signal to T cells, so reduced functioning is associated with increased T-lymphocyte activity.[18][19] A family history of thyroid disorders is common, with the HLA-DR5 [en.wikipedia.org]

Lacrimal Gland Disorder

C Syndrome

[11] and to HLA-DR5 in Greek and Israeli persons. [12] Some evidence indicates that the true association of Sjögren syndrome may be with HLA-DQA1, which is in linkage disequilibrium [emedicine.medscape.com]

In white persons, for instance, the condition is linked to human leukocyte antigen (HLA)–DR3, HLA-DQ2, and HLA-B8, [10] whereas the linkage is to HLA-DRB1*15 in Spanish persons [emedicine.medscape.com]

Familial Thyroid Dyshormonogenesis Type 6

HLA-DR5 and HLA-DR3. Well differentiated thyroid cancer which may evolve into thyroid lymphoma Also - may coexist with SLE or RA Describe Reidel thyroiditis. [quizlet.com]

Tongue Disease

La Crosse Encephalitis

Of La Crosse encephalitis patients with acute-phase seizures, only 2 (7%) were positive for HLA-DR5, whereas 16 (37%) of nonseizure patients were positive for that antigen [ncbi.nlm.nih.gov]

Infected individuals with HLA-DR5 had a lower relative risk of developing seizures (relative risk 0.22, χ 2 = 5.10, P < 0.025) [ 41 ]. [ncbi.nlm.nih.gov]

Nine patients (11%) and none of the control population had HLA-B49 (P < .01, uncorrected for multiple comparisons). [ncbi.nlm.nih.gov]

Palindromic Rheumatism

The HLA genotype of the mother was HLA A2, Cw4, Bw41, Bw6, DR5, MT2/Aw32, CX, Bw44, Bw4, DR1, MT1. [ncbi.nlm.nih.gov]

HLA DR5 has previously been found to be associated with juvenile rheumatoid arthritis, while DR1 in Jews is significantly associated with adult-onset rheumatoid arthritis. [ncbi.nlm.nih.gov]

All 4 members were seronegative and the HLA types of the children were identical. [ncbi.nlm.nih.gov]

Neutrophil Immunodeficiency Syndrome

Font, MP, Gebuhrer L, Bétuel H, Freidel C, Dausset J, Cohen D (1986) HLA-DR2,-DR5 and-DRw6 associatet Dw subtypes correlate with HLA-DRβ and-DQβ restriction fragment length [link.springer.com]

Durandy A, Virelizier JL, Griscelli C (1983) Enhancement by interferon of membrane HLA antigens in patients with combined immunodeficiency with defective HLA expression. [link.springer.com]

Autoimmune Hypophysitis

HLA DR4 allele, HLA DR5 allele (DR4 > DR5) Recent association found with HLA DQ8 and DR53 alleles as well Can be associated with antibody to PIT1 (POU1F1) Risk Factors Female [unboundmedicine.com]

Eiken Syndrome

Neonatal Scleroderma

C- B- DR5 DRw52 DQw3 haplotype. [ncbi.nlm.nih.gov]

[…] positive antinuclear antibodies (ANA) (proband) had diffuse cutaneous and visceral scleroderma (systemic sclerosis, SSc), antitopoisomerase autoantibodies and shared the HLA-A23 [ncbi.nlm.nih.gov]

The ANA- granddaughter (daughter of the proband) was noted to have severe isolated pulmonary hypertension within the first 6 months of life, and had the other maternal HLA-A1 [ncbi.nlm.nih.gov]