HLA-DR5 Causes & Reasons

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HLA-DR5 Symptom Checker: Possible causes include Geographic Tongue. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

HLA-DR5,

Negated

None

Unsure

None

Possible Causes

Geographic Tongue

[…] combination with conditions such as chronic granulomatous disease, fissured tongue and psoriasis. [4], [5] Unknown causes, allergic rhinitis, asthma, human leukocyte antigens (HLA-DR5 [njgp.org]

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.com]

HLADRW6, and HLA-CW6), congenital condition, atopy, inflammation, and polygenic mode are postulated causes. [3], [6], [7], [8], [9], [10] Usually the condition is asymptomatic [njgp.org]

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Juvenile Seronegative Polyarthritis

ICD.Codes ICD-10-CM (2016) Chapter 13 Section M05-M14 Code M08.3 BILLABLE Billable Code Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis. ICD-10 from 2011 - 2016 M08.3 is a billable ICD code used to specify a diagnosis of juvenile rheumatoid polyarthritis[…] [icd.codes]

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Thyroiditis

Commonly Associated Conditions Postpartum thyroiditis: family history of autoimmune thyroid disease; HLA-DRB, HLA-DR4, and HLA-DR5 -- To view the remaining sections of this [unboundmedicine.com]

[…] euthyroidism so must monitor thyroid function ( Clin Endocrinol (Oxf) 2009;71:451 ) No female predominance in children with Down syndrome ( Horm Res 2008;70:278 ) Associated with HLA-DR5 [pathologyoutlines.com]

The goitrous form (rather than atrophic) is associated with HLA-DR5. [patient.info]

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Salivary Gland Disorder

A sicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosis. Lancet 2: 466 - 468. [doi.org]

[…] infiltration, sarcoid, amyloid, tuberculosis, leukemia, and lymphoma, but now also a Sjögren's syndrome—like disorder related to the human immunodeficiency virus and linked to HLA-DR5 [nejm.org]

A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DR5. [doi.org]

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Chronic Fibrous Thyroiditis

postpartum thyroiditis) • Specific alleles (HLA-DR3, HLA-DR4, HLA-DR5) in Caucasian populations • Elevated iodine intake (at least 0.5 mg/day) • Selenium deficiency • Amiodarone [clinicaladvisor.com]

There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [humpath.com]

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Hashimoto Thyroiditis

[…] euthyroidism so must monitor thyroid function (Clin Endocrinol (Oxf) 2009;71:451) No female predominance in children with Down syndrome (Horm Res 2008;70:278) Associated with HLA-DR5 [pathologyoutlines.com]

The goitrous form (rather than atrophic) is associated with HLA-DR5. Twin studies indicate that there is about 70% genetic contribution to autoimmune thyroid disease[3]. [patient.info]

[…] inhibitory signal to T cells, so reduced functioning is associated with increased T-lymphocyte activity.[18][19] A family history of thyroid disorders is common, with the HLA-DR5 [en.wikipedia.org]

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Constipation

HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7. Hum Immunol 1992;35(3):188–92. [worldgastroenterology.org]

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Allergic Bronchopulmonary Aspergillosis

Although not familial in most patients, presentation of Asp f1 antigen is restricted to specific major histocompatability complex class II molecules, HLA-DR2 and HLA-DR5. [ncbi.nlm.nih.gov]

Individuals with the HLA DR2 and HLA DR5 haplotypes appear to be predisposed to ABPA. Procedure see individual test information [viracoribt.com]

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Hypersensitivity

HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7. Hum Immunol 1992;35(3):188–92. [worldgastroenterology.org]

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Stomatitis

The HLA-DR5 frequency, differently from our findings, was predominant in these patients. On the other hand, the HLA-DR4 frequency was reduced. [scielo.br]

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Lymphocytic Interstitial Pneumonia

A host immune response associated with HLA-DR5. Ann Intern Med 1990;112:3-10. Contributed by Sonya Arnold, MD and Susan Hasegawa, MD, PhD [path.upmc.edu]

Patients positive for HLA-DR5 and HLA-DR6 alleles are predisposed to developing a diffuse visceral lymphocytosis syndrome with LIP. [emedicine.com]

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Sjögren Syndrome

According to Israeli research ,HLA-DR5 is associated with S.S in Israelipersons.Possible disease triggersViruses are viable candidates as environmental triggers, uncertain [slideshare.net]

[…] with HLA-DR3 and HLA-DR5. [13] These HLA associations appear restricted to individuals with Sjögren syndrome who have antibodies to the antigens SSA and SSB rather than to [emedicine.com]

Some evidence indicates that the true association of Sjögren syndromemay be with HLA-DQA1. [slideshare.net]

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Atopy

[…] and DR5. [doi.org]

Freidhoff LR, Ehrlich-Kautzky E, Bias WB, Roebber M: Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 [doi.org]

PubMed View Article Google Scholar Freidhoff LR, Ehrlich-Kautzky E, Meyers DA, Ansari AA, Bias WB, Marsh DG: Association of HLA-DR3 with human immune response to Lol p I and [doi.org]

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Dermatitis

Dermatomyositis rarely occurs in multiple family members, but a link to certain human leukocyte antigen (HLA) types (eg, DR3, DR5, DR7) may exist. [emedicine.medscape.com]

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Food Allergy

HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7. Hum Immunol 1992;35(3):188–92. [worldgastroenterology.org]

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Oral Candidiasis

[…] cells.(76) No evidence of Epstein-Barr virus or cytomegalovirus has been found in biopsies of salivary glands.(86) One report describes an association between HIV-SGD and HLA-DR5 [hivinsite.ucsf.edu]

[…] and HLA-B35 cell-surface antigen.(87) The etiology of HIV-SGD is as yet unknown but the enlarged parotid glands can be a source of annoyance and discomfort. [hivinsite.ucsf.edu]

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Folliculotropic Mycosis Fungoides

HLA-DR5 and DQB1*03 class II alleles are associated with cutaneous T-cell lymphoma. J Invest Dermatol. 1996; 107 :373–6. [ PubMed ] [ Google Scholar ] 14. [ncbi.nlm.nih.gov]

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Autoimmune Gastritis

In T1D patients, a weak association has been observed between PCA positivity and the HLADQA10501B10301 haplotype linked to HLA-DR5 [9]. [novapublishers.org]

Although the association between pernicious anemia and particular HLA haplo/genotypes is weak, studies evaluate HLA DR4, with DR2 and DR5 haplotypes. [intechopen.com]

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Polyarticular Juvenile Idiopathic Arthritis

DR5 (HLA-DR5) test puts patients at increased risk for developing uveitis. [eyewiki.aao.org]

[…] association HLA DRB1*0401, 0404, 0101 in Caucasians EOPA: HLA-A2, -DR5, -DR8, - DPB1*0201. [arthritis-research.biomedcentral.com]

It appears to have association with HLA alleles other than B27 (e.g. HLA-DR5). [pathophys.org]

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Silent Thyroiditis

Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: Evidence supporting an autoimmune pathogenesis. J. Clin. [link.springer.com]

There may be an inherited component (there is a high frequency of both HLA-DR3 and HLA-DR5 in patients with this type of thyroiditis) and/or an autoimmune component (patients [pathologystudent.com]

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Hypothyroidism

Crossref, Medline, Google Scholar 295 Vargas MT Briones-Urbina R Gladman D Papsin FR Walfish PG 1988 Antithyroid microsomal autoantibodies and HLA-DR5 are associated with [doi.org]

Vargas MT, Briones-Urbina R, Gladman D, Papsin FR, Walfish PG 1988 Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: evidence [doi.org]

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Riedel Thyroiditis

[…] most common cause of hypothyroidism; an autoimmune disorder (thyroid peroxydase, antithyroglobulin antibodies) Associated with HLA-DR5. [memorize.com]

• There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [de.slideshare.net]

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Autoimmune Hypophysitis

HLA DR4 allele, HLA DR5 allele (DR4 DR5) Recent association found with HLA DQ8 and DR53 alleles as well Can be associated with antibody to PIT1 (POU1F1) Risk Factors Female [unboundmedicine.com]

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Glossitis

Associations with human leukocyte antigen HLA DR5, HLA DRW6 and HLA Cw6 have been reported. Maintaining a good oral hygiene may prevent glossitis. [symptoma.com]

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.medscape.com]

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Irritable Bowel Syndrome

HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7. Hum Immunol 1992;35(3):188–92. [worldgastroenterology.org]

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Hashitoxicosis

Genetic predisposition :HLA-DR3 & DR5 Immune causes Immune Regulatory Genes [CTLA4, PTPN22] cytotoxic T lymphocyte–associated antigen-4 (CTLA4) protein tyrosine phosphatase [ilovepathology.com]

(goitrous form), HLA-DR3 (atrophic form) May coexist with SLE, rheumatoid arthritis, Sjögren syndrome, pernicious anemia, type 2 diabetes, Graves disease, chronic active [pathologyoutlines.com]

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Aphthous Stomatitis

The HLA-DR5 frequency, differently from our findings, was predominant in these patients. On the other hand, the HLA-DR4 frequency was reduced. [scielo.br]

[…] and HLA-DR5 and lower incidence of HLA-B5 and HLA-DR4 (Albanidou-Farmaki et al. 1988 ; Gallina et al. 1985 ) was observed when compared to healthy controls. [dx.doi.org]

In patients with RAS, a higher incidence of HLA-A33, HLA-B35 and HLA-B81 (Wilhelmsen et al. 2009 ), HLA-B12 (Lehner et al. 1982 ), HLA-B51 (Özdemir et al. 2009 ), HLA-DR7 [dx.doi.org]

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Oligoarthritis

No patient was typed for HLA DR5. No other clinical or biological symptom appeared during a mean follow-up period of 5.5 years (6 mo-30 yrs). [ncbi.nlm.nih.gov]

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Juvenile Idiopathic Arthritis

[…] association HLA DRB1*0401, 0404, 0101 in Caucasians EOPA: HLA-A2, -DR5, -DR8, - DPB1*0201. [doi.org]

It appears to have association with HLA alleles other than B27 (e.g. HLA-DR5). [pathophys.org]

HLA interaction between A2, DR5/8-DR/DQ, and DPB1*0201 is a general feature of all subsets of early onset pauciarticular juvenile chronic arthritis II. [arthritis-research.biomedcentral.com]

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Diabetes Mellitus Type 1

Her HLA type was A3, A9, B8, B15, DR3, DR5. [ncbi.nlm.nih.gov]

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