HLA-DR5: Causes & Reasons

Possible Causes for HLA-DR5

[…] combination with conditions such as chronic granulomatous disease, fissured tongue and psoriasis. [4], [5] Unknown causes, allergic rhinitis, asthma, human leukocyte antigens (HLA-DR5 [njgp.org]

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.com]

HLADRW6, and HLA-CW6), congenital condition, atopy, inflammation, and polygenic mode are postulated causes. [3], [6], [7], [8], [9], [10] Usually the condition is asymptomatic [njgp.org]

Juvenile Seronegative Polyarthritis

Juvenile Arthritis Also called: Childhood arthritis, JRA, Juvenile idiopathic arthritis, Still's disease Juvenile arthritis (JA) is arthritis that happens in children. It causes joint swelling, pain, stiffness, and loss of motion. It can affect any joint, but is more common in the knees, hands, and feet. In some cases it can[…] [icdlist.com]

Chronic Fibrous Thyroiditis

[…] euthyroidism so must monitor thyroid function ( Clin Endocrinol (Oxf) 2009;71:451 ) No female predominance in children with Down syndrome ( Horm Res 2008;70:278 ) Associated with HLA-DR5 [pathologyoutlines.com]

HLA-DR4, HLA-DR5) in Caucasian populations • Elevated iodine intake (at least 0.5 mg/day) • Selenium deficiency • Amiodarone • Exposure to ionizing radiation • Turner syndrome [clinicaladvisor.com]

There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [humpath.com]

Thyroiditis

Commonly Associated Conditions Postpartum thyroiditis: family history of autoimmune thyroid disease; HLA-DRB, HLA-DR4, and HLA-DR5 -- To view the remaining sections of this [unboundmedicine.com]

The goitrous form (rather than atrophic) is associated with HLA-DR5. [patient.info]

Allergic Bronchopulmonary Aspergillosis

Although not familial in most patients, presentation of Asp f1 antigen is restricted to specific major histocompatability complex class II molecules, HLA-DR2 and HLA-DR5. [ncbi.nlm.nih.gov]

Individuals with the HLA DR2 and HLA DR5 haplotypes appear to be predisposed to ABPA. Procedure see individual test information [viracoribt.com]

Riedel Thyroiditis

[…] most common cause of hypothyroidism; an autoimmune disorder (thyroid peroxydase, antithyroglobulin antibodies) Associated with HLA-DR5. [memorize.com]

• There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [slideshare.net]

Folliculotropic Mycosis Fungoides

HLA-DR5 and DQB1*03 class II alleles are associated with cutaneous T-cell lymphoma. J Invest Dermatol. 1996;107:373–6. [PubMed] [Google Scholar] 14. [ncbi.nlm.nih.gov]

Salivary Gland Disorder

A sicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosis. Lancet 2: 466 - 468. [doi.org]

[…] infiltration, sarcoid, amyloid, tuberculosis, leukemia, and lymphoma, but now also a Sjögren's syndrome—like disorder related to the human immunodeficiency virus and linked to HLA-DR5 [nejm.org]

A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DR5. [doi.org]

Autosomal Recessive Anterior Segment Dysgenesis

HLA-A3 (35.5%), A4 (41%), B5 (41.2%), DR5 (47%) and DR7 (47%) were the most frequent antigenic types in our patients. [emro.who.int]

Frequencies of different HLA class I antigens in our patients did not differ significantly from those of the general population of Khorasan province (chi-squared P > 0.05) [emro.who.int]

Idiopathic Hypersomnia

Despite some reports that suggest an increased frequency of human leukocyte antigen (HLA) Cw2 and HLA DR5 in idiopathic hypersomnia, [ 19 ] HLA typing is of no help in the [beatcfsandfms.org]

[…] greater than the 5.7% found in controls ( P < 0.05), and an association with HLA-DR11, a subtype of DR5, in 42.1% of patients but in only 26% of controls. [beatcfsandfms.org]

In the author's population of 32 probands, an increased frequency of HLA-Cw2 and DR11 was not present, but there was a significant increase of DQ3 ( P < 0.04). [beatcfsandfms.org]

Chronic Thyroiditis

[…] inhibitory signal to T cells, so reduced functioning is associated with increased T-lymphocyte activity. [16] [17] A family history of thyroid disorders is common, with the HLA-DR5 [en.wikipedia.org]

Lymphocytic Interstitial Pneumonia

A host immune response associated with HLA-DR5. Ann Intern Med 1990;112:3-10. Contributed by Sonya Arnold, MD and Susan Hasegawa, MD, PhD [path.upmc.edu]

Patients positive for HLA-DR5 and HLA-DR6 alleles are predisposed to developing a diffuse visceral lymphocytosis syndrome with LIP. [emedicine.com]

Silent Thyroiditis

There may be an inherited component (there is a high frequency of both HLA-DR3 and HLA-DR5 in patients with this type of thyroiditis) and/or an autoimmune component (patients [pathologystudent.com]

Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: Evidence supporting an autoimmune pathogenesis. J. Clin. [link.springer.com]

Fissured Tongue

Associations with human leukocyte antigens (HLA)-DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [7] BMG has also been linked to allergies. [jisppd.com]

Some have reported links with various human leukocyte antigens, such as increased incidence of HLA-DR5, HLA-DRW6 and HLA-Cw6 and decreased incidence in HLA-B51. [10] Vitamin [en.wikipedia.org]

Sjögren Syndrome

According to Israeli research ,HLA-DR5 is associated with S.S in Israelipersons.Possible disease triggersViruses are viable candidates as environmental triggers, uncertain [slideshare.net]

[…] with HLA-DR3 and HLA-DR5. [13] These HLA associations appear restricted to individuals with Sjögren syndrome who have antibodies to the antigens SSA and SSB rather than to [emedicine.medscape.com]

Some evidence indicates that the true association of Sjögren syndromemay be with HLA-DQA1. [slideshare.net]

Hashitoxicosis

Genetic predisposition :HLA-DR3 & DR5 Immune causes Immune Regulatory Genes [CTLA4, PTPN22] cytotoxic T lymphocyte–associated antigen-4 (CTLA4) protein tyrosine phosphatase [ilovepathology.com]

Immunological mechanisms Associations with HLA-DR3, and DR5 have been proposed [3] Cellular (especially T cells) and humoral immune responses are activated;. → active B lymphocytes [www-amboss-com.db.rsu.lv]

Familial Thyroid Dyshormonogenesis Type 1

Autoimmune desctruction of thyroid gland Assoc: HLA-DR5 Most common cause of hypothyroid when sufficient iodine Presents Initial: hyp er thyroidism Destroy follicles TH stored [alancam.com]

Glossitis

Associations with human leukocyte antigen HLA DR5, HLA DRW6 and HLA Cw6 have been reported. Maintaining a good oral hygiene may prevent glossitis. [symptoma.com]

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.medscape.com]

Hashimoto Thyroiditis

[…] euthyroidism so must monitor thyroid function (Clin Endocrinol (Oxf) 2009;71:451) No female predominance in children with Down syndrome (Horm Res 2008;70:278) Associated with HLA-DR5 [pathologyoutlines.com]

The goitrous form (rather than atrophic) is associated with HLA-DR5. Twin studies indicate that there is about 70% genetic contribution to autoimmune thyroid disease[3]. [patient.info]

[…] inhibitory signal to T cells, so reduced functioning is associated with increased T-lymphocyte activity.[18][19] A family history of thyroid disorders is common, with the HLA-DR5 [en.wikipedia.org]

Polyarticular Juvenile Idiopathic Arthritis

DR5 (HLA-DR5) test puts patients at increased risk for developing uveitis. [eyewiki.aao.org]

[…] association HLA DRB1*0401, 0404, 0101 in Caucasians EOPA: HLA-A2, -DR5, -DR8, - DPB1*0201. [arthritis-research.biomedcentral.com]

It appears to have association with HLA alleles other than B27 (e.g. HLA-DR5). [pathophys.org]

Lacrimal Gland Disorder

Familial Thyroid Dyshormonogenesis Type 6

HLA-DR5 and HLA-DR3. Well differentiated thyroid cancer which may evolve into thyroid lymphoma Also - may coexist with SLE or RA Describe Reidel thyroiditis. [quizlet.com]

Tongue Disease

Neutrophil Immunodeficiency Syndrome

Font, MP, Gebuhrer L, Bétuel H, Freidel C, Dausset J, Cohen D (1986) HLA-DR2,-DR5 and-DRw6 associatet Dw subtypes correlate with HLA-DRβ and-DQβ restriction fragment length [link.springer.com]

Durandy A, Virelizier JL, Griscelli C (1983) Enhancement by interferon of membrane HLA antigens in patients with combined immunodeficiency with defective HLA expression. [link.springer.com]

Neonatal Scleroderma

C- B- DR5 DRw52 DQw3 haplotype. [ncbi.nlm.nih.gov]

[…] positive antinuclear antibodies (ANA) (proband) had diffuse cutaneous and visceral scleroderma (systemic sclerosis, SSc), antitopoisomerase autoantibodies and shared the HLA-A23 [ncbi.nlm.nih.gov]

The ANA- granddaughter (daughter of the proband) was noted to have severe isolated pulmonary hypertension within the first 6 months of life, and had the other maternal HLA-A1 [ncbi.nlm.nih.gov]

Palindromic Rheumatism

The HLA genotype of the mother was HLA A2, Cw4, Bw41, Bw6, DR5, MT2/Aw32, CX, Bw44, Bw4, DR1, MT1. [ncbi.nlm.nih.gov]

HLA DR5 has previously been found to be associated with juvenile rheumatoid arthritis, while DR1 in Jews is significantly associated with adult-onset rheumatoid arthritis. [ncbi.nlm.nih.gov]

All 4 members were seronegative and the HLA types of the children were identical. [ncbi.nlm.nih.gov]

La Crosse Encephalitis

Of La Crosse encephalitis patients with acute-phase seizures, only 2 (7%) were positive for HLA-DR5, whereas 16 (37%) of nonseizure patients were positive for that antigen [ncbi.nlm.nih.gov]

Infected individuals with HLA-DR5 had a lower relative risk of developing seizures (relative risk 0.22, χ 2 = 5.10, P < 0.025) [ 41 ]. [ncbi.nlm.nih.gov]

Nine patients (11%) and none of the control population had HLA-B49 (P < .01, uncorrected for multiple comparisons). [ncbi.nlm.nih.gov]

Eiken Syndrome

[11] and to HLA-DR5 in Greek and Israeli persons. [12] Some evidence indicates that the true association of Sjögren syndrome may be with HLA-DQA1, which is in linkage disequilibrium [emedicine.medscape.com]

In white persons, for instance, the condition is linked to human leukocyte antigen (HLA)–DR3, HLA-DQ2, and HLA-B8, [10] whereas the linkage is to HLA-DRB1*15 in Spanish persons [emedicine.medscape.com]

AIDS-Associated Nephropathy

Itescu S, Brancato LJ, Winchester R (1989) Asicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosis. Lancet 2: 466-468. [omicsonline.org]

Gold Sodium Thiomalate

RESULTS: HLA-DR5 was significantly increased in patients who developed gold induced mucocutaneous lesions. [ncbi.nlm.nih.gov]

METHODS: Ninety consecutive patients with rheumatoid arthritis (RA) were studied for possible association between HLA antigens and adverse reactions to GSTM therapy. [ncbi.nlm.nih.gov]