HLA-DR7: Causes & Reasons

Possible Causes for HLA-DR7

Increased risk in those with possession of HLA-DR7 allele. Minimal change disease is highly responsive to corticosteroids and with treatment displays a good prognosis. [pathwaymedicine.org]

•Increased risk of MCD in those with possession of HLA-DR7 allele 32. [slideshare.net]

Associated with atopy in children, especially those who are HLA-DR7-positive. May also be related to underlying Hodgkin's disease in adults. [patient.info]

Persistent Polyclonal B-cell Lymphocytosis

Other notable findings in this case are lack of HLA-DR7 and strong positive CD5 markers in the polyclonal B-cell population. [ncbi.nlm.nih.gov]

This recently identified distinct clinicopathologic entity is frequently associated with the presence of the HLA-DR7 antigen. [serval.unil.ch]

Persistent polyclonal B-cell lymphocytosis with binucleate lymphocytes is a rare lymphoproliferative syndrome of uncertain cause that is strongly associated with HLA-DR7 positivity [ncbi.nlm.nih.gov]

Pigeon Breeder's Lung

Our results showed a significant increase of the antigen HLA-DR7 (corrected P less than 0.001) in patients with pigeon breeder's lung and an equally important difference in [ncbi.nlm.nih.gov]

Stevens-Johnson Syndrome

Carriage of the following human leukocyte antigens has been associated with increased risk: HLA-B*1502 HLA-B*5801 HLA-B*44 HLA-A29 HLA-B12 HLA-DR7 HLA-A2 HLA-B*5801 HLA-A* [emedicine.medscape.com]

: Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 359,727–732 ( 2002 ). [doi.org]

HLA-A29, HLA-B12, and HLA-DR7 are frequently associated with sulfonamide-induced Stevens-Johnson syndrome, while HLA-A2 and HLA-B12 are often encountered in Stevens-Johnson [emedicine.medscape.com]

Abacavir

HLA-B*5701, HLA-DR7, and HLA-DQ3 were present in combination in 13 (72%) hypersensitive patients and none of the tolerant patients (822 [43-15 675], p(c)<0.0001). [ncbi.nlm.nih.gov]

HSR more common in Caucasians and associated with HLA-DR7, HLA-DQ3, and HLA-B*5701 haplotypes. [hopkinsguides.com]

[…] the absence of HLA-B57 –associated ancestral haplotype markers in central and class II major histocompatibility complex regions (i.e., C4A6 and HLA-DR7/HLA-DQ3 ). [doi.org]

Idiosyncratic Drug-Induced Liver Injury

*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. [f1000.com]

*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse transcriptase inhibitor abacavir. [genomemedicine.biomedcentral.com]

| CrossRef 12 Mallal S, Nolan D, Witt C, Masel G, Martin AM, Moore C, Sayer D, Castley A, Mamotte C, Maxwell D, James I, Christiansen FT: Association between presence of HLA-B [f1000.com]

Ipp-Gelfand Syndrome

[…] in the presence of HLA-DR7; HLA-DQ3 in the absence of HLA-DR7 Protective: HLA-B22 Comparing psoriasis with psoriatic arthritis, it has been found that in psoriatic arthritis [emedicine.medscape.com]

HLA-B27, HLA-DR4, HLA-38, and HLA-DR7 Psoriasis and psoriatic arthritis: HLA-Cw6, HLA-B13, HLA-B17, HLA-B57, and HLA-B39 Predictors of disease progression: HLA-B39; HLA-B27 [emedicine.medscape.com]

[…] and psoriatic arthritis is not yet clear) [18, 24, 25, 26, 27, 28, 29, 30] : Early-onset psoriasis: HLA-Cw6, HLA-B57, HLA-DR7, and HLA-B17, with HLA-Cw*0602 variant found [emedicine.medscape.com]

Autosomal Recessive Anterior Segment Dysgenesis

HLA-A3 (35.5%), A4 (41%), B5 (41.2%), DR5 (47%) and DR7 (47%) were the most frequent antigenic types in our patients. [emro.who.int]

Frequencies of different HLA class I antigens in our patients did not differ significantly from those of the general population of Khorasan province (chi-squared P > 0.05) [emro.who.int]

Antiphospholipid Syndrome

DR7, DR4, DQw7 and DRw53. [patient.info]

[…] thrombosis in young people and 15% of cases of recurrent fetal loss. [ 4 ] There is a familial association in some cases of APS, with apparently increased risk associated with HLA [patient.info]

Psoriatic Arthritis

[…] and psoriatic arthritis is not yet clear) [17, 23, 24, 25, 26, 27, 28, 29] : Early-onset psoriasis: HLA-Cw6, HLA-B57, HLA-DR7, and HLA-B17, with HLA-Cw*0602 variant found [emedicine.medscape.com]

Rheumatic Valvulitis

Human leukocyte antigen (HLA) class II allele DR7 (HLA-DR7) is most often associated with RHD, and its combination with certain DQ alleles is seemingly associated with the [textbookofcardiology.org]

Human leukocyte antigen (HLA) class II allele DR7 ( HLA-DR7 ) is most often associated with RHD, and its combination with certain DQ alleles is seemingly associated with the [en.wikipedia.org]

Acute Rheumatic Heart Disease

Human leukocyte antigen (HLA) class II allele DR7 ( HLA-DR7 ) is most often associated with RHD, and its combination with certain DQ alleles is seemingly associated with the [en.wikipedia.org]

The HLA-DR7 allele seems to be most frequently associated with the disease [ 27 ]. [omicsonline.org]

Nephrotic Syndrome Type 9

In the patient group, HLA-DR7 and HLA-CW6 were found to be significantly increased, while HLA-DQW1 and HLA-CW4 were significantly reduced. [cags.org.ae]

DR7. [emedicine.medscape.com]

[…] involving a group of 48 Arab children with steroid responsive childhood nephritic syndrome and a control group consisting of healthy Arab children, to see if there was any HLA [cags.org.ae]

Drug Hypersensitivity

Science 1998; 282:490-493. ‎ 93 ページ - Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reversetranscriptase inhibitor abacavir [books.google.com]

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet. 2002;359:727–732. [ncbi.nlm.nih.gov]

Hughes-Stovin Syndrome

Microscopic colitis Limited, S Ulcerative colitis [15] Limited, A IV Tissue Blood Antiphospholipid syndrome [15] Moderate, M, A HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. [immunologyonline.wordpress.com]

Microscopic colitis Limited, S Ulcerative colitis [15] Limited, A IV Antiphospholipid syndrome [15] Moderate, M, A HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. [dranakmu.wordpress.com]

Posttransplant Lymphoproliferative Disease

HLA-DR analysis demonstrated a significant negative association between the expression of HLA-DR7 (OR 0.46, CI 0.28-0.78, P < 0.004) and PTLD. [ncbi.nlm.nih.gov]

Three locus haplotype analysis underlined the relevance of a dominant protective effect of HLA-DR7 expression concerning the risk of PTLD development. [ncbi.nlm.nih.gov]

CONCLUSIONS: Our data suggest an influence of HLA variants on the risk of the development of PTLD. [ncbi.nlm.nih.gov]

Recurrent Oral Ulceration

These results suggest that HLA-B12, B5, DR7 and DR2 might in some way be associated with tissue localization of disease. [ncbi.nlm.nih.gov]

Alternatively, since patients with HLA-B12 show a significantly greater ratio of IgG:IgA circulating immune complexes than those with B5/DR7/DR2, tissue localization might [ncbi.nlm.nih.gov]

The immunogenetic basis of the four types of BS was extended from HLA-B locus to the DR locus. [ncbi.nlm.nih.gov]

Nephrotic Syndrome Type 1

In the patient group, HLA-DR7 and HLA-CW6 were found to be significantly increased, while HLA-DQW1 and HLA-CW4 were significantly reduced. [cags.org.ae]

[…] involving a group of 48 Arab children with steroid responsive childhood nephritic syndrome and a control group consisting of healthy Arab children, to see if there was any HLA [cags.org.ae]

Insulin Antibody

IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack [ncbi.nlm.nih.gov]

Nephrotic Syndrome Type 8

In the patient group, HLA-DR7 and HLA-CW6 were found to be significantly increased, while HLA-DQW1 and HLA-CW4 were significantly reduced. [cags.org.ae]

[…] involving a group of 48 Arab children with steroid responsive childhood nephritic syndrome and a control group consisting of healthy Arab children, to see if there was any HLA [cags.org.ae]

Psoriatic Juvenile Idiopathic Arthritis

HLA-B39, HLA-B27 in the presence of HLA-DR7 and HLA-DQ3 in the absence of HLA-DR7 are said to be predictors of progression of the disease whereas HLA-B22 is said to be protective [boneandspine.com]

The disease is autoimmune-mediated with defined HLA associations (HLA-B27, -B17, -CW6, -DR4, -DR7 and others). [patient.info]

Glomerulonephritis

Associated with atopy in children, especially those who are HLA-DR7-positive. May also be related to underlying Hodgkin's disease in adults. [patient.info]

Diffuse Proliferative Glomerulonephritis

Associated with atopy in children, especially those who are HLA-DR7-positive. May also be related to underlying Hodgkin's disease in adults. [patient.info]

Pneumonitis

Increase of HLA-DR7 in pigeon breeder’s lung in a Mexican population. [revistas.asoneumocito.org]

Immunoglobulin-Mediated Membranoproliferative Gomerulonephritis

Associated with atopy in children, especially those who are HLA-DR7-positive. May also be related to underlying Hodgkin's disease in adults. [patient.info]

Rapidly Progressive Glomerulonephritis

HLA antigen types HLA-DR7 and HLA-DR1 are thought to confer some protection against developing Goodpasture syndrome. [rarediseases.info.nih.gov]

Associated with atopy in children, especially those who are HLA-DR7-positive. May also be related to underlying Hodgkin's disease in adults. [patient.info]

Anti-GBM disease is seen less often with HLA-DR1 and HLA-DR7; both have strong negative associations, and both are highly protective. [emedicine.medscape.com]

Nephrotic Syndrome Type 2

DR7. [emedicine.medscape.com]

Steroid sensitive INS has also been associated with HLA-B8 and the DQB1 gene of HAL-DQW2. [emedicine.medscape.com]

[…] diet was associated with improved proteinuria and complete remission in one study. [8] Additionally, INS is 3-4 times more likely in children with human leukocyte antigen (HLA [emedicine.medscape.com]

Psoriasis

Genetic studies (HLA typing: -Cw6, -B57, -DR7) How can psoriasis be prevented? [clinicaladvisor.com]

HLA-B38, HLA-B39, HLA-Cw6, HLA-DR4, and HLA-DR7. [emedicine.com]

Idiopathic Membranous Glomerulonephritis

Associated with atopy in children, especially those who are HLA-DR7-positive. May also be related to underlying Hodgkin's disease in adults. [patient.info]

10q22.3-q23.3 Microdeletion Syndrome

DR7. [emedicine.medscape.com]

Steroid sensitive INS has also been associated with HLA-B8 and the DQB1 gene of HAL-DQW2. [emedicine.medscape.com]