HLA-DRw3: Causes & Reasons

Possible Causes for HLA-DRw3

The histocompatibility complex profile includes HLA-B8, HLA-DRw3, and HLA-DQw2 (though these have not been shown to be associated with the strictly ocular form of MG). [web.archive.org]

The histocompatibility complex profile includes HLA-A1, -A3, -B7, -B8, -DRw3, and -DQw2 (though these have not been shown to be associated with the strictly ocular form of [emedicine.com]

For example, females and people with certain human leukocyte antigen (HLA) types have a genetic predisposition to autoimmune diseases. [web.archive.org]

Systemic Lupus Erythematosus

Increased frequency of HLA-DRw3 in systemic lupus erythematosus Tissue Antigens 1980 15 : 283–288 41 Gladman KK, Urowitz MB, Darlinkton GA. [doi.org]

HLA-DRw3 and systemic lupus erythematosus Arthritis Rheum 1980 23 : 954–957 50 So AK, Fielder AH, Warner CA, Isenberg DA, Batchelor JR, Walport MJ. [doi.org]

Disease expression and class II HLA antigens in systemic lupus erythematosus Lupus 1999 8 : 466–470 42 Hashimoto H, Tsuda H, Matsumoto T et al. [doi.org]

Diabetes Mellitus

Abstract Type 2 diabetes mellitus (T2DM) is a growing and serious global health problem. Inhibition of the sodium--glucosecotransporter-2 (SGLT2) can increase urinary glucose excretion and decrease plasma glucose levels in an insulin-independent manner. Ertugliflozin is a highly selective inhibitor of SGLT2, and was[…] [ncbi.nlm.nih.gov]

Membranoproliferative Glomerulonephritis

Membranoproliferative glomerulonephritis (MPGN) is a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane (GBM) thickening, activating complement and damaging the glomeruli. MPGN accounts for approximately 4% of primary renal causes of nephrotic syndrome in children[…] [en.wikipedia.org]

Rapidly Progressive Glomerulonephritis

Rapidly progressive glomerulonephritis is characterized by the acute, rapid loss of renal function due to severe glomerular damage. The glomerular filtration rate decreases significantly over days, weeks, to months and may result in irreversible renal failure. Patients with rapidly progressive glomerulonephritis may[…] [symptoma.com]

Herpes Gestationis

Background Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis of pregnancy (see the image below). The disease was originally named herpes gestationis for the herpetiform morphology of the blisters, but this term is a misnomer because pemphigoid gestationis is not related to or associated with any[…] [emedicine.medscape.com]

Familial Hyperthyroidism due to Mutations in TSH Receptor

DRw3 and HLA-B89. [emedicine.medscape.com]

[…] also have immune deficiency, as manifested by chronic mucosal candidiasis. [8] Autoimmune thyroid disease has a higher prevalence in patients with human leukocyte antigen (HLA [emedicine.medscape.com]

Hyperthyroidism

DRw3 and HLA-B89. [emedicine.com]

[…] also have immune deficiency, as manifested by chronic mucosal candidiasis. [8] Autoimmune thyroid disease has a higher prevalence in patients with human leukocyte antigen (HLA [emedicine.com]

Thyrotoxicosis Factitia

DRw3 and HLA-B89. [emedicine.medscape.com]

[…] also have immune deficiency, as manifested by chronic mucosal candidiasis. [9] Autoimmune thyroid disease has a higher prevalence in patients with human leukocyte antigen (HLA [emedicine.medscape.com]

Stromal Keratitis

An increased frequency HLA-DRw3 was found in the patient group (35%) compared to the control group (23%) but the P value was not statistically significant HLA-DRw7 was also [link.springer.com]

HLA-DR antigens have been determined in over 34 patients with recurrent HSV stromal keratitis (HSV type 1). [link.springer.com]

Toxic Nodular Goiter

There is an underlying genetic predisposition, because of an increased frequency of haplotypes human leukocyte antigen (HLA)-B8 and HLA-DRw3 in white patients, HLA-Bw36 in [entokey.com]

Thyrotoxicosis

DRw3 and HLA-B89. [emedicine.medscape.com]

Immune System Disorder

HLA-B8, DRw3, and DQw2.1 MuSK antibody-positive myasthenia is associated with haplotypes (clusters of genes inherited together) DR14 and DQ5.2 Most studies suggest that if [mda.org]

Certain human leukocyte antigen (HLA) types, cell-surface proteins that are responsible for the regulation of the immune system, have been associated with myasthenia, including [mda.org]

Superficial Punctate Keratopathy Type Thygeson

Strong association between the HLA-Dw3-related B cell alloantigen -DRw3 and coeliac disease. Scand J Gastroenterol. 1978;13(2):229–233. [ncbi.nlm.nih.gov]

Membranous Glomerulonephritis

Strong association between idiopathic membranous nephropathy and HLA-DRW3. Lancet 1979 ;2: 770 - 771 24. Vaughan RW, Demaine AG, Welsh KI. [doi.org]

Mania

DRw3 and HLA-B89. [emedicine.medscape.com]

Gold Salt Poisoning

PubMed Citation (HLA testing on another 91 patients with rheumatoid arthritis found DRw3/HLA B8 in 14 of 15 patients who developed proteinuria on gold or penicillamine therapy [livertox.nih.gov]

Dermatitis Herpetiformis

HLA-B8/Dw3/DRw3) and B cell alloantigens; (2) an associated gluten-sensitive enteropathy, (3) the presence of IgA in the skin. [link.springer.com]

Conclusions Attempts to address the pathophysiology of dermatitis herpetiformis must take the following characteristics into account: (1) a high frequency of certain HLA [link.springer.com]

Multi-Infarct Dementia

The histocompatibility complex profile includes HLA-A1, -A3, -B7, -B8, -DRw3, and -DQw2 (though these have not been shown to be associated with the strictly ocular form of [emedicine.medscape.com]

However, HLA genotyping is not routinely used in the evaluation of patients suspected to have MG. [emedicine.medscape.com]

For example, people with certain human leukocyte antigen (HLA) types have a genetic predisposition to autoimmune diseases. [emedicine.medscape.com]

Addison Disease

Strong association between the HLA-Dw3-related B cell alloantigen -DRw3 and coeliac disease. Scand J Gastroenterol. 1978; 13 :229-233. [ PubMed ] [ DOI ] 16. [doi.org]

Pyoderma

However, HLA genotyping is not routinely used in the evaluation of patients suspected to have MG. [emedicine.medscape.com]

For example, people with certain human leukocyte antigen (HLA) types have a genetic predisposition to autoimmune diseases. [emedicine.medscape.com]

Acquired Cutis Laxa

[…] with HLA DW3 and DRW3. [wjgnet.com]

HLA studies in patients, who have DH based on clinical and immunological criteria, have shown that 85-90% are HLA B8-positive and that there is an even stronger association [wjgnet.com]