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2,290 Possible Causes for Holoprosencephaly, Secondary Hypothyroidism, Syndactyly between Adjacent Toes

  • Septo-Optic Dysplasia

    In lobar holoprosencephaly which is the least severe form of other holoprosencephalies (alobar and semilobar), there is always varying degrees of fusion of the two cerebral[] At the end of the first year of clinical follow-up, secondary hypothyroidism was detected and L-thyroxine was added to the treatment.[] None of these three patients had interhemispheric fusion in any form, excluding holoprosencephaly. They had normal facies.[]

    Missing: Syndactyly between Adjacent Toes
  • Pallister-Hall Syndrome

    ) Syndactyly (abnormal "webbing" between, or fusing of, adjacent fingers and/or toes) Short limbs Dysplastic nails ( i.e., finger nails and toe nails that are flaky and poorly[] The spectrum of these anomalies is wide, ranging from alobar holoprosencephaly to microforms, such as isolated single central medial incisive, or cleft palate.[] Hypothyroidism, microphallus, and cryptorchidism have been reported also.[]

  • Craniosynostosis Type 3

    Examples of these defects include hydrocephalus, holoprosencephaly, multicystic renal dysplasia and severe hydrops.[] ., holoprosencephaly, microcephaly, shunted hydrocephalus, encephalocele) Exposure of fetus (e.g., valproic acid, phenytoin) Mucopolysaccharidosis (e.g., Hurler’s syndrome[] Hematologic disorders Congenital hemolytic icterus Polycythemia vera Sickle cell anemia Thalassemia Iatrogenic disorders Hydrocephalus with shunt Malformations Encephalocele Holoprosencephaly[]

    Missing: Secondary Hypothyroidism
  • Panhypopituitarism

    Sarcoidosis Commonly Associated Conditions Midline defects such as cleft lip/palate, hypotelorism, single central maxillary incisor Septo-optic dysplasia (de Morsier syndrome) Holoprosencephaly[] Biochemically he had hypovolemic hyponatremia, secondary hypothyroidism and adrenal insufficiency.[] Clinical findings Galactorrhoea, amenorrhoea or oligomenorrhoea, secondary hypothyroidism, cold intolerance, hypotension, bradycardia, weight gain, hair loss, adrenal insufficiency[]

    Missing: Syndactyly between Adjacent Toes
  • Pulmonary Histiocytosis X

    ヒスチオサイトーシスX histocompatibility antigen 組織適合性抗原 histoplasmosis ヒストプラスマ症 hives/urticaria 蕁麻疹 holding chamber スペーサー holocarboxylase synthetase ホロカルボキシラーゼ合成酵素 holoenzyme ホロ酵素 holoprosencephaly[]

    Missing: Syndactyly between Adjacent Toes
  • Adrenal Insufficiency Secondary to Hypopituitarism

    Adrenal crisis secondary to hypocortisolism (vomiting, hypotension) Failure to thrive Midline defects (cleft palate) Neurodevelopmental abnormalities (septo-optic dysplasia, holoprosencephaly[] Case report: We present a case of a 43-year-old woman with hypopituitarism, probably due to autoimmune hypophysitis with secondary hypothyroidism, secondary adrenal insufficiency[] Low-normal TSH with low free T3 and T4 was consistent with secondary hypothyroidism. Serum IGF-1 was also low.[]

    Missing: Syndactyly between Adjacent Toes
  • Hemochromatosis

    Iron overload disease has a wide variety of genotypes. The genetic study of this disease confirms its hereditary nature and enables us to provide genetic counseling for first-degree relatives. We performed magnetic resonance imaging and liver biopsy in an asymptomatic patient with more than 1,000 µg/L of serum[…][]

    Missing: Holoprosencephaly Syndactyly between Adjacent Toes
  • Growth Failure

    ., cleft palate, septo-optic dysplasia, or holoprosencephaly).[] Multiple biochemical abnormalities secondary to hypothyroidism were also present (Table 1 ). Her serum prolactin was not measured.[] […] found were pituitary gland hypoplasia or aplasia, ectopic pituitary gland, septooptic dysplasia, isolated absence of septum pellucidum, stalk abnormalities, empty sella, and holoprosencephaly[]

    Missing: Syndactyly between Adjacent Toes
  • Smith Lemli Opitz Syndrome

    The diagnosis of alobar holoprosencephaly was confirmed at 15 weeks of gestation, and cardiac and limb defects were also identified.[] Hypothyroidism, microphallus, and cryptorchidism have been reported also.[] Here we present a 24-week fetus with Smith-Lemli-Opitz syndrome (SLOS), alobar holoprosencephaly (HPE) and cyclopia (synophthalmia).[]

    Missing: Syndactyly between Adjacent Toes
  • Hypopituitarism

    Developmental central nervous system (CNS) defects: • Anencephaly • Holoprosencephaly • Pituitary aplasia or hypoplasia IDIOPATHIC 11.[] Secondary hypothyroidism is a rare cause of pericardial effusion and tamponade, but an important differential to consider.[] The highly variable phenotype may consist of isolated hypopituitarism, or more complex disorders such as septo-optic dysplasia and holoprosencephaly.[]

    Missing: Syndactyly between Adjacent Toes