Homocystinuria
From Wikidata Jump to navigation Jump to search amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine[wikidata.org]
When the body cannot process vitamin B12 as it should, blood levels of homocysteine increase, and blood levels of methionine decrease.[cystadane.com]
Increased homocysteine results in various vascular and neurological complications.[ncbi.nlm.nih.gov]
Vitamin B12 Deficiency
Each 5-μmol/L increase above 10 μmol/L of serum homocysteine is associated with a 20% increased risk of circulatory health problems.[ncbi.nlm.nih.gov]
Even when B12 values were 1500 pg/ml (n 36), increased MMA and homocysteine values occurred in 31 and 23 % of subjects, respectively.[ncbi.nlm.nih.gov]
Homocysteine concentrations did not normalize at 4 months (and actually increased during treatment in 4).[bloodjournal.org]
Anemia
In the absence of folic acid, homocysteine levels increase rapidly because it cannot be converted into methionine.[dx.doi.org]
In human and rodent serum and CSF, concomitantly with a vitamin B-12 decrease, EGF levels are decreased, while at the same time, TNF-alpha increases in step with homocysteine[web.archive.org]
Normal serum levels of homocysteine are highly unlikely in folate deficiency[ 21 ].[dx.doi.org]
Essential Hypertension
BACKGROUND/AIMS: Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure.[ncbi.nlm.nih.gov]
Alcohol Abuse
A steep rise in S-adenosylhomocysteine as well as homocysteine levels was demonstrated with increased alcohol ingestion, with a decreased S-adenosylmethionine:S-adenosylhomocysteine[ncbi.nlm.nih.gov]
These were concomitant with compromised OCM, as evidenced by elevated homocysteine, a marker of OCM dysfunction.[doi.org]
The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage.[doi.org]
Insulin Resistance
Nevertheless, homocysteine and Lp(a) concentrations remain increased, not modulated by vitamin D treatment.[ncbi.nlm.nih.gov]
In fact, anyone with a high C-reactive protein has a 1,700 percent increased risk of getting diabetes.[drhyman.com]
This is consistent with the increased TG, very low density lipoprotein (VLDL) secretion, and atherosclerosis associated with chronic fructose feeding.[doi.org]
Hyperuricemia
Possible mechanisms for the association between homocysteine and atherosclerosis include stimulating smooth muscle cell growth, reducing endothelial cell growth and endothelial[ncbi.nlm.nih.gov]
HUA causes endothelial dysfunction and thereby increases oxidative stress, inducing vascular smooth muscle cell proliferation and reducing endothelial nitric oxide bioavailability[ncbi.nlm.nih.gov]
Chronic Alcoholism
DISCUSSION: An increase in homocysteine levels is common in alcoholics, and it has been considered a vascular risk factor.[ncbi.nlm.nih.gov]
In addition, an association between brain atrophy and increased levels of homocysteine in chronic alcoholism was shown.[ncbi.nlm.nih.gov]
[…] associated with their elevated homocysteine levels (multiple linear regression, p 0.001).[ncbi.nlm.nih.gov]
Oral Candidiasis
Andy Sun, Hung‐Pin Lin, Yi‐Ping Wang and Chun‐Pin Chiang , Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric[doi.org]
Victor Ching, Miriam Grushka, Mark Darling and Nan Su , Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study , Oral Surgery, Oral Medicine[doi.org]
Polycystic Ovary Syndrome
Compared with control women, patients with PCOS presented higher circulating concentrations of homocysteine (23% increase, SMD 0.6, 95CI, 0.4-0.8), malondialdehyde (47% increase[ncbi.nlm.nih.gov]
L-methyl-folate increases peripheral sensitivity to insulin, maintaining folatemia stable, and thus restoring normal homocysteine levels.[ncbi.nlm.nih.gov]
[…] in C-reactive protein and homocysteine levels after 6 months of this treatment, although there were no changes in insulin parameters or lipid profile (53). 1.[doi.org]