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423 Possible Causes for Homocysteine Increased

  • Homocystinuria

    From Wikidata Jump to navigation Jump to search amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine[] When the body cannot process vitamin B12 as it should, blood levels of homocysteine increase, and blood levels of methionine decrease.[] Increased homocysteine results in various vascular and neurological complications.[]

  • Vitamin B12 Deficiency

    Each 5-μmol/L increase above 10 μmol/L of serum homocysteine is associated with a 20% increased risk of circulatory health problems.[] Even when B12 values were 1500 pg/ml (n 36), increased MMA and homocysteine values occurred in 31 and 23 % of subjects, respectively.[] Homocysteine concentrations did not normalize at 4 months (and actually increased during treatment in 4).[]

  • Anemia

    In the absence of folic acid, homocysteine levels increase rapidly because it cannot be converted into methionine.[] In human and rodent serum and CSF, concomitantly with a vitamin B-12 decrease, EGF levels are decreased, while at the same time, TNF-alpha increases in step with homocysteine[] Normal serum levels of homocysteine are highly unlikely in folate deficiency[ 21 ].[]

  • Essential Hypertension

    BACKGROUND/AIMS: Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure.[]

  • Alcohol Abuse

    A steep rise in S-adenosylhomocysteine as well as homocysteine levels was demonstrated with increased alcohol ingestion, with a decreased S-adenosylmethionine:S-adenosylhomocysteine[] These were concomitant with compromised OCM, as evidenced by elevated homocysteine, a marker of OCM dysfunction.[] The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage.[]

  • Insulin Resistance

    Nevertheless, homocysteine and Lp(a) concentrations remain increased, not modulated by vitamin D treatment.[] In fact, anyone with a high C-reactive protein has a 1,700 percent increased risk of getting diabetes.[] This is consistent with the increased TG, very low density lipoprotein (VLDL) secretion, and atherosclerosis associated with chronic fructose feeding.[]

  • Hyperuricemia

    Possible mechanisms for the association between homocysteine and atherosclerosis include stimulating smooth muscle cell growth, reducing endothelial cell growth and endothelial[] HUA causes endothelial dysfunction and thereby increases oxidative stress, inducing vascular smooth muscle cell proliferation and reducing endothelial nitric oxide bioavailability[]

  • Chronic Alcoholism

    DISCUSSION: An increase in homocysteine levels is common in alcoholics, and it has been considered a vascular risk factor.[] In addition, an association between brain atrophy and increased levels of homocysteine in chronic alcoholism was shown.[] […] associated with their elevated homocysteine levels (multiple linear regression, p 0.001).[]

  • Oral Candidiasis

    Andy Sun, Hung‐Pin Lin, Yi‐Ping Wang and Chun‐Pin Chiang , Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric[] Victor Ching, Miriam Grushka, Mark Darling and Nan Su , Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study , Oral Surgery, Oral Medicine[]

  • Polycystic Ovary Syndrome

    Compared with control women, patients with PCOS presented higher circulating concentrations of homocysteine (23% increase, SMD 0.6, 95CI, 0.4-0.8), malondialdehyde (47% increase[] L-methyl-folate increases peripheral sensitivity to insulin, maintaining folatemia stable, and thus restoring normal homocysteine levels.[] […] in C-reactive protein and homocysteine levels after 6 months of this treatment, although there were no changes in insulin parameters or lipid profile (53). 1.[]

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