Homocysteine Increased Causes & Reasons

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Homocysteine Increased Symptom Checker: Possible causes include Homocystinuria. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Homocystinuria

When the body cannot process vitamin B12 as it should, blood levels of homocysteine increase, and blood levels of methionine decrease. [cystadane.com]

From Wikidata Jump to navigation Jump to search amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine [wikidata.org]

[…] acid) in the blood increase. [cystadane.com]

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Vitamin B12 Deficiency

Each 5-μmol/L increase above 10 μmol/L of serum homocysteine is associated with a 20% increased risk of circulatory health problems. [ncbi.nlm.nih.gov]

Even when B12 values were 1500 pg/ml (n 36), increased MMA and homocysteine values occurred in 31 and 23 % of subjects, respectively. [ncbi.nlm.nih.gov]

Homocysteine concentrations did not normalize at 4 months (and actually increased during treatment in 4). [bloodjournal.org]

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Anemia

In the absence of folic acid, homocysteine levels increase rapidly because it cannot be converted into methionine. [dx.doi.org]

In human and rodent serum and CSF, concomitantly with a vitamin B-12 decrease, EGF levels are decreased, while at the same time, TNF-alpha increases in step with homocysteine [web.archive.org]

Normal serum levels of homocysteine are highly unlikely in folate deficiency[ 21 ]. [dx.doi.org]

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Essential Hypertension

BACKGROUND/AIMS: Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. [ncbi.nlm.nih.gov]

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Alcohol Abuse

A steep rise in S-adenosylhomocysteine as well as homocysteine levels was demonstrated with increased alcohol ingestion, with a decreased S-adenosylmethionine:S-adenosylhomocysteine [ncbi.nlm.nih.gov]

These were concomitant with compromised OCM, as evidenced by elevated homocysteine, a marker of OCM dysfunction. [doi.org]

The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage. [doi.org]

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Chronic Alcoholism

DISCUSSION: An increase in homocysteine levels is common in alcoholics, and it has been considered a vascular risk factor. [ncbi.nlm.nih.gov]

In addition, an association between brain atrophy and increased levels of homocysteine in chronic alcoholism was shown. [ncbi.nlm.nih.gov]

[…] associated with their elevated homocysteine levels (multiple linear regression, p 0.001). [ncbi.nlm.nih.gov]

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Insulin Resistance

Nevertheless, homocysteine and Lp(a) concentrations remain increased, not modulated by vitamin D treatment. [ncbi.nlm.nih.gov]

In fact, anyone with a high C-reactive protein has a 1,700 percent increased risk of getting diabetes. [drhyman.com]

[…] concentration was significantly reduced in patients with type 2 diabetes versus control subjects; this decrease in plasma HDL cholesterol was accounted for entirely by an increase [circ.ahajournals.org]

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Hyperuricemia

Possible mechanisms for the association between homocysteine and atherosclerosis include stimulating smooth muscle cell growth, reducing endothelial cell growth and endothelial [ncbi.nlm.nih.gov]

HUA causes endothelial dysfunction and thereby increases oxidative stress, inducing vascular smooth muscle cell proliferation and reducing endothelial nitric oxide bioavailability [ncbi.nlm.nih.gov]

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Oral Candidiasis

Victor Ching, Miriam Grushka, Mark Darling and Nan Su, Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study, Oral Surgery, Oral Medicine [doi.org]

Andy Sun, Hung‐Pin Lin, Yi‐Ping Wang and Chun‐Pin Chiang, Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal [doi.org]

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Arthritis

High homocysteine levels have been linked to an increased risk of heart disease. Many people with RA have elevated homocysteine levels. [upi.com]

Folate is essential in the creation of new cells and lowers levels of homocysteine, an amino acid found in blood. [upi.com]

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Vaginospasm

The probability of developing glaucoma increases with age for patients with microspherophakia. [afvp.info]

Screening tests may be required for associated systemic conditions like serum homocysteine levels and urine screening test for homocysteinuria. [afvp.info]

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Renal Function Impairment

[…] rate; Homocysteine; Renal insufficiency; Stroke [ncbi.nlm.nih.gov]

Patients with AIS and HHcy had a 2.42-3.51 fold increase of the risk of renal impairment compared with patients with normal Hcy level (P KEYWORDS: Cystatin C; Glomerular filtration [ncbi.nlm.nih.gov]

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Inadequate Dietary Intake of Folic Acid

Homocysteine increases as folate decreases in plasm of healthy men during short term dietary folate and methyl group restriction. J Nutr 1994;124:1072-80. [nrv.gov.au]

homocysteine levels Thrombocytopenia [expand title ”References for Folic Acid Deficiency Mnemonic:”] – – – – [/expand] [medical-institution.com]

Although increased homocysteine concentrations in the blood have been consistently associated with increased risk of CVD, it is unclear whether lowering circulating homocysteine [lpi.oregonstate.edu]

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Polycystic Ovary Syndrome

Compared with control women, patients with PCOS presented higher circulating concentrations of homocysteine (23% increase, SMD 0.6, 95CI, 0.4-0.8), malondialdehyde (47% increase [ncbi.nlm.nih.gov]

L-methyl-folate increases peripheral sensitivity to insulin, maintaining folatemia stable, and thus restoring normal homocysteine levels. [ncbi.nlm.nih.gov]

[…] in homocysteine levels 1,500 to 2,250 mg daily 4 for 1,000 mg twice daily Menstrual irregularities (second-line therapy added to hormonal contraceptives) Hirsutism (third-line [aafp.org]

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Raynaud Disease

Homocysteine has been also linked to the pathogenesis of RP, as increased serum homocysteine (S-homocysteine) levels were observed in patients with RP. [scielo.br]

[…] with RP have increased S-homocysteine levels, suggesting that homocysteine plays an important role in the development of vascular dysfunction even at an early age. [scielo.br]

CONCLUSION: Paediatric patients with RP have increased S-homocysteine levels, suggesting that homocysteine plays an important role in the development of vascular dysfunction [scielo.br]

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Presbycusis

RT-quantitative PCR and Western blotting showed reduced levels of enzymes catalyzing homocysteine (Hcy) production and recycling, together with a 30% increase in protein homocysteinylation [dx.doi.org]

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Osteoporosis

Collagen abnormalities A polymorphism of the first intron of the gene coding for the type I collagen 1 chain and increased levels of homocysteine can influence fracture risk [web.archive.org]

Even mild to moderate vitamin B-12 deficiency appears to be sufficient to increase bone turnover ( 73 ). [dx.doi.org]

Adverse effects of increased dietary folate. Relation to measures to reduce the incidence of neural tube defects. [ods.od.nih.gov]

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Alzheimer Disease

They suspect that increased levels of homocysteine in the brain caused damage to the DNA of nerve cells in the hippocampus. [web.archive.org]

Elevated plasma total homocysteine levels increased the risk for dementia in the elderly. ACP J Club. 2002; 137(2) :76. [ PubMed ] [ Google Scholar ] 16. [ncbi.nlm.nih.gov]

Abstract Alzheimer's disease (AD) is increasing in prevalence, and environmental risk factors have not been identified with certainty. [ncbi.nlm.nih.gov]

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Diabetes Mellitus

[…] in the MTHFD1L pathway may increase plasma homocysteine level 48, 53. [doi.org]

[…] associated with increased risk of coronary and other atherosclerotic disease 51. [doi.org]

Another enzyme in the same pathway, methylene THF reductase (encoded by MTHFR ) is subject to a common mutation which influences plasma homocysteine level 50 and has been [doi.org]

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Folic Acid Deficiency

Increased plasma homocysteine is a functional marker of both folate and vitamin B12 deficiency. Increased homocysteine levels are found in depressive patients. [ncbi.nlm.nih.gov]

homocysteine levels Thrombocytopenia [expand title ”References for Folic Acid Deficiency Mnemonic:”] – – – – [/expand] [medical-institution.com]

Abstract The increasing possibility that homocysteine might be involved in atherosclerosis in non-homocysteinuric subjects has required the measurement of low concentrations [ncbi.nlm.nih.gov]

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Cerebral Thrombosis

Homocysteine increases smooth muscle cell proliferation and enhances collagen production. [hindawi.com]

The C6777 T mutation of the MTHFR gene makes the enzyme less active resulting in an elevated homocysteine level and increasing the risk for thrombosis. [nature.com]

Oxidative stress by free radicals formed during the oxidation of reduced homocysteine may directly injure endothelial cells. [hindawi.com]

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Anxiety Disorder

Laboratory investigations that need to be done if the condition is suspected include assays of plasma total homocysteine (increase), plasma methionine (increase) and urinary [ncbi.nlm.nih.gov]

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Alcohol Withdrawal

Homocysteine increases with active drinking, and in withdrawal, excitotoxicity likely is induced by a further increase in homocysteine, viewed as a risk factor for AWS and [ncbi.nlm.nih.gov]

Homocysteine levels, which are elevated during chronic drinking, increase even further during the withdrawal state, and may result in excitotoxicity. [en.wikipedia.org]

Characteristics involves changes in the ECG, especially an increase in QT interval, and EEG changes, including abnormal quantified EEG, at times periodic lateralized epileptiform [ncbi.nlm.nih.gov]

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Hypercholesterolemia

[…] lipoprotein (a) (Lp[a]), increased serum homocysteine, and abnormalities in several coagulation factors. [doi.org]

The simvastatin-niacin group had increased ALT, CK, uric acid, and homocysteine. Antioxidant vitamins diminished the beneficial effect of niacin on HDL-C. [circ.ahajournals.org]

In addition, patients with a genetic defect in an enzyme producing high homocysteine levels also appear to be at increased risk for CHD. 123 124 Whether measurement of plasma [doi.org]

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Thrombosis

However, not a huge risk factor, as smoking, diabetes, HTN, HLD tend to increase your risk for these events more than elevated homocysteine levels. [errolozdalga.com]

Homocysteine and thrombotic disease. Blood, 90: 1-11, 1997. 14-Cattaneo M, Martinelli I and Manucci P. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. [scla.org.sy]

High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: rôle of increased synthesis and relationship to the acute phase reaction. [scla.org.sy]

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Exfoliation Syndrome

homocysteine concentration was a significant risk factor for exfoliation syndrome in the presence of glaucoma (odds ratio per 1.0 micromol/l increase in homocysteine 1.2, [ncbi.nlm.nih.gov]

Increased plasma homocysteine level may be a risk factor for the development of glaucoma [ 46 ]. [ncbi.nlm.nih.gov]

Homocysteine concentration has been found to be elevated[83] or unaffected[77] in aqueous humor of patients with PEX glaucoma, while increased in PEX glaucoma patients’ tears [wjgnet.com]

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Carotid Stenosis

A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995 ; 274 :1049–1057. [dx.doi.org]

(New recommendation) Hyperhomocysteinemia Homocysteine may increase risk for stroke through multiple mechanisms: thrombosis, impaired thrombolysis, increased production of [dx.doi.org]

[…] hydrogen peroxide, endothelial dysfunction, and increased oxidation of LDL-C. 636, 637 Cohort and case-control studies have consistently demonstrated a roughly 2-fold greater [dx.doi.org]

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Coronary Atherosclerosis

However, vegetarians have a number of increased risk factors for non-communicable diseases such as increased plasma homocysteine, mean platelet volume and platelet aggregability [ncbi.nlm.nih.gov]

But high levels of homocysteine may increase your risk of coronary artery disease. Preeclampsia. [mayoclinic.org]

However, vegetarians have a number of increased risk factors for non‐communicable diseases such as increased plasma homocysteine, mean platelet volume and platelet aggregability [doi.org]

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Hypothyroidism

Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism which, in itself, has been associated with a significant raise of homocysteine (Hcy) levels and increased [ncbi.nlm.nih.gov]

Renal system: decreased urinary output, laboratory findings may show increased serum creatinine, proteinuria, hyperkalemia and increased plasma homocystein concentrations. [flexikon.doccheck.com]

[…] metabolism, 117 thereby modulating homocysteine levels. 118,119 Other studies indicated that the increase in homocysteine concentrations during hypothyroidism might also [stroke.ahajournals.org]

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Stroke

[…] of total homocysteine increase thrombosis, 54 impair endothelial function, 55–57 and increase oxidative stress. 58–60 Treatment to lower total homocysteine with folate, B [doi.org]

On the other hand, many vegetarians have a low intake of vitamin B12, which might be responsible for raising homocysteine, an amino acid in the blood, thereby increasing the [medscape.com]

A 5-μmol/L increase in serum homocysteine was associated with an increased OR in ischemic heart disease (OR 1.42; 95% CI 1.11 to 1.89) and an OR for stroke of 1.59 (95% CI [doi.org]

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