Based on their iodine uptake on radioiodine scans, thyroid nodules may be autonomous/hot (increased uptake) or non-functional/cold (decreased uptake).
[amboss.com]
Reduction (%) of nodule volume was 66 +/- 23, 57 +/- 18, and 79 +/- 13, respectively, in groups 1, 2, and 3, with scintigraphic disappearance of hot nodules or persistence
[ncbi.nlm.nih.gov]
As hot nodules are rarely malignant, such thyroid nodules would not require cytological evaluation.9 A higher TSH is often associated with chronic autoimmune (Hashimoto’s)
[touchendocrinology.com]
