Howell-Jolly Bodies: Causes & Reasons

Possible Causes for Howell-Jolly Bodies

[…] lack of Howell-Jolly bodies in asplenic patients is suggestive of the presence of an accessory spleen ! [amboss.com]

Abstract Asplenia was suspected in one patient with combined immunodeficiency syndrome and 5 with congenital cardiac anomalies who had Howell-Jolly bodies on peripheral blood [ncbi.nlm.nih.gov]

bodies were seen Spleen could not be visualised Absence of spleen in scintigraphy ( Fig. 4 ) Howell-Jolly bodies in the peripheral blood smear (case 3) Absence of spleen [ncbi.nlm.nih.gov]

Thalassaemia-Haemoglobin C Disease

[…] poikilocytosis Target cells, ovalocytes, occasional fragmented red blood cells, basophilic stippling, increased polychromatophilic cells (but insufficient for the degree of anemia), Howell-Jolly [clinlabnavigator.com]

Heinz bodies -target cells -Howell-Jolly bodies -leukocytosis Sickle gene offers some protection against malaria What is the probable etiologic association between malaria [quizlet.com]

Nucleated red cells and Howell-Jolly bodies are often present. The total WBC count is elevated to 12,000-20,000/cmm, with a predominance of neutrophils. [ndri.com]

Splenectomy

A dictionary of medical eponyms Related people Justin Marie Jolly William Henry Howell Spherical granules, 1-2 µ, seen in erythrocytes in slides of stained blood. [whonamedit.com]

Often, Howell-Jolly bodies on peripheral blood film give an important clue to diagnosing hyposplenism. [patient.info]

Splenectomy patients typically have Howell-Jolly bodies and less commonly Heinz bodies in their blood smears. [en.wikipedia.org]

Folate-Deficiency Anemia

Multinucleate RBCs, abnormal karyorrhexis, increased pyknosis, and Howell-Jolly bodies ( right) may be seen. [med-ed.virginia.edu]

Pernicious Anemia

[…] the blood smear findings were characteristic of megaloblastic anemia (marked anisopoikilocytosis with frequent oval macrocytes and teardrop cells, basophilic stippling, Howell-Jolly [academic.oup.com]

bodies, and hypersegmented neutrophils), prompting additional testing that confirmed megaloblastic anemia secondary to pernicious anemia (methylmalonic acid, 2,669 nmol/L [academic.oup.com]

Acute Leukemia

Other features are; fragmentation, Howell-Jolly bodies, ring sideroblast, megaloblastic and dyserythropoiesis changes are common. [intechopen.com]

• Howell-Jolly bodies, ring sideroblast, megaloblastoid and dyserythropoietic changes • Coarse positivity of PAS • IHC: glycophorin A 33. [slideshare.net]

Autoimmune Hemolytic Anemia

In both panels, Howell–Jolly bodies (asterisks) are indicative of asplenia. Table 1. Table 1. [nejm.org]

Leukemia

What is leukemia? Leukemia is cancer of the blood and develops in the bone marrow. The bone marrow is the soft, spongy center of certain bones that produces the three major types of blood cells: white blood cells to fight infection; red blood cells that carry oxygen; and platelets that help with blood clotting[…] [stanfordchildrens.org]

Normocytic Normochromic Anemia

Howell-Jolly bodies are DNA remnants seen with a macrocytic anemia or a damaged spleen. [physicianassistantexamreview.com]

Heinz Bodies in G6PD Deficiency D. Acanthocytes in abetalipoproteinemia E. Acanthocytes and Howell-jolly bodies in liver diseas F. [pitt.edu]

Sore/swollen tongue GI issues: diarrhea Mouth and peptic ulcers Symptoms of anemia Labs CBC Low H&H Elevated MCV Low retic count Peripheral blood smear Macro-ovalocytes Howell-Jolly [physicianassistantexamreview.com]

Leukoerythroblastic Anemia

Research of Cabot's Ring Body (morphologic Abnormality) has been linked to Anemia, Anemia, Pernicious, Howell-jolly Bodies, Neoplasm Metastasis, Leukoerythroblastic Anemia [novusbio.com]

Any inclusion bodies (eg, Howell-Jolly bodies or malarial parasites) will also be noted. [patient.info]

Howell-Jolly bodies: round nuclear remnants within the red cells. Indicate splenectomy or hyposplenism h. [kerrybrandis.com]

Beta Thalassaemia Major

Funding Profiles Access available for Technion staff. Please sign in to see the Agency profiles (upper left corner) The Cooley’s Anemia Foundation is dedicated to serving people afflicted with various forms of thalassemia, most notably the major form of this genetic blood disease, Cooley’s anemia/thalassemia major.[…] [trdf.co.il]

Precursor-Cell Lymphoblastic Leukemia

Also called: acute lymphocytic leukemia, acute lymphoid leukemia, ALL What is acute lymphoblastic leukemia? Acute lymphoblastic leukemia (ALL) is a cancer that affects the white blood cells. These cells fight infection and help protect the body against disease. Patients with ALL have too many immature white blood cells[…] [stjude.org]

Refractory Megaloblastic Anemia

Peripheral blood: normochromic macrocytic anemia, often pancytopenia, significant anisocytosis, poikilocytosis, polychromasia is absent, neutrophilic hypersegmentation, Howell-Jolly [atlases.muni.cz]

- Many nucleated RBCs may be seen resulting in leucoerythroblastic reaction - Howell Jolly bodies and Cabot’s rings may be seen. [sites.google.com]

Erythropoeisis• Usually megaloblastic erythropoeisis• Feature of dyserthropoiesis• Some precursors may show Howell Jolly bodies• Vacoulization, basophilia and poor hemoglobinisation [slideshare.net]

Megaloblastic Anemia

Howell-Jolly bodies (residual fragments of the nucleus) are usually present. [msdmanuals.com]

Howell-Jolly bodies (residual fragments of the nucleus) are common. Reticulocytopenia is present. [merckmanuals.com]

Severe Idiopathic Pneumococcemia

These include occasional Howell-Jolly bodies and erythrocyte pits (see “Laboratory Features,”). [medtextfree.wordpress.com]

[…] or other red blood cell inclusions (peripheral blood has Howell-Jolly bodies if no functional spleen is present) White pulp: Forms sheaths of lymphoid cells around arteries [pathologyoutlines.com]

Physicians need to know of the spectrum of diseases associated with hyposplenism and how pat ients noted to have Howell-Jolly bodies should be investi gated. [ziladoc.com]

Macrocytic Anemia

Howell-Jolly bodies are DNA remnants seen with a macrocytic anemia or a damaged spleen. [physicianassistantexamreview.com]

Howell-Jolly bodies (residual fragments of the nucleus) are usually present. [merckmanuals.com]

Acquired Spherocytosis

Splenectomized patients, Functional asplenia, Anatomical absence of spleen Howell Jolly bodies Howell-Jolly bodies are small round bodies composed of DNA, about 1 µm in diameter [slideshare.net]

Red cell inclusion bodies: Howell-Jolly bodies (spherical basophilic bodies comprising nuclear remnants) occur in hyposplenic states including post-splenectomy and sickle-cell [cancertherapyadvisor.com]

Howell-Jolly bodies are seen in •Post splenectomy •Functional asplenia •Anatomical absence of spleen 31. [slideshare.net]

Splenosis

although the presence of Howell – Jolly bodies do argue for a functional splenic volume 6 ]. [academic.oup.com]

The diagnosis of intrathoracic ectopic spleen was suspected because of the history of spleen trauma with diaphragm rupture and the absence of Howell-Jolly bodies. [ncbi.nlm.nih.gov]

bodies. 4,5 Figure 4. [acgcasereports.gi.org]

Familial Isolated Congenital Asplenia

Familial asplenia Howell-Jolly bodies Isolated congenital asplenia Pneumococcal sepsis This is a preview of subscription content, log in to check access. [link.springer.com]

CONCLUSION: in the case of Streptococcus pneumoniae sepsis, a systematic search for Howell-Jolly bodies on blood smears and ultrasound examination of the abdomen for the presence [ncbi.nlm.nih.gov]

bodies were seen Spleen could not be visualised Absence of spleen in scintigraphy ( Fig. 4 ) Howell-Jolly bodies in the peripheral blood smear (case 3) Absence of spleen [ncbi.nlm.nih.gov]

Congenital Heinz Body Hemolytic Anemia

"Howell‐Jolly body counting as a measure of splenic function. A reassessment." Clinical & Laboratory Haematology 12.3 (1990): 269-275. Bain, Barbara J. [derangedphysiology.com]

Usually, only one per cell is seen but, occasionally, there may be more than one Megaloblastic anaemia Mylodysplastic Howell-Jolly Bodies Heinz Bodies Heinz Bodies Cabot Rings [medical-labs.net]

Howell-Jolly Bodies: Howell-Jolly Bodies are remnants of nuclear DNA in red blood cells. [hematologylearning.weebly.com]

Beta-Thalassemia Associated with Another Hemoglobin Anomaly

Auer bodies B. Howell-Jolly bodies C. Heinz bodies D. [quizlet.com]

Howell-Jolly bodies B. basophilic stippling C. Heinz bodies D. [quizlet.com]

Hypochromic Microcytic Anemia with Iron Overload Type 2

Howell-Jolly Bodies: Howell-Jolly Bodies are remnants of nuclear DNA in red blood cells. [hematologylearning.weebly.com]

You may see Howell-Jolly bodies, these are pieces of nuclear remnants that are normally degraded by spleen. This can be a sign of markedly decreased splenic function. [nextgencombatmedic.com]

The four most common RBC inclusions are Howell-Jolly bodies, Pappenheimer bodies, Heinz bodies and basophilic stippling. [hematologylearning.weebly.com]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

As the spleen becomes compromised with repeated infarctions, Howell-Jolly bodies are also seen. [nhsggc.org.uk]

Definition basophilic stippling, heinz bodies. Term Are Howell Jolly bodies associated with Thalassemia? [flashcardmachine.com]

 Will see polychromasia, basophilic stippling, and NRBCs,occasionally RBC with Howel Jolly bodies. 21. 2) RETIC COUNT Reticulocyte count Usually elevated. [slideshare.net]

Hereditary Orotic Aciduria without Megaloblastic Anemia

Howell-Jolly bodies (chromosomal remnant) also present. Blood chemistries will also show: An increased lactic acid dehydrogenase (LDH) level. [en.wikipedia.org]

Other findings include Howell-Jolly bodies, anisocytosis, and poikilocytosis. [ncbi.nlm.nih.gov]

bodies, cabot rings). [intechopen.com]

Hereditary Cryohydrocytosis with Reduced Stomatin

[…] increase risk of infection, esp pneumococcal After splenectomy: cells seen (4) howell-jolly bodies target cells siderocytes (pappenheimer bodies) acanthrocytes Other causes [quizlet.com]

Howell-Jolly bodies and spherocytes are seen (peripheral blood, ×1000). [doctorlib.info]

After splenectomy, spherocytes are still apparent on the blood film, and all of the typical changes in RBC morphology seen after splenectomy also are observed, including Howell-Jolly [doctorlib.info]

Splenic Artery Embolism

The appearance of Howell-Jolly bodies on a peripheral blood smear is reported useful for assessing splenic function. [hrjournal.net]

Jolly bodies and platelet levels. [link.springer.com]

The appearance of Howell-Jolly bodies in peripheral erythrocytes has drawn attention as an indicator of reduced splenic function. [hrjournal.net]

Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

Absence of Howell-Jolly bodies or pitted erythrocytes by microscopic examination of erythrocytes rules against congenital asplenia. [clinicalgate.com]

[…] both forms of leukocyte adhesion deficiency, in which elevated counts are present even between infections) Platelet count (normal result excludes Wiskott-Aldrich syndrome) Howell-Jolly [slideplayer.com]

bodies (presence suggests asplenia) Erythrocyte sedimentation rate (normal result indicates chronic bacterial or fungal infection unlikely) Screening Tests for B-Cell Defects [slideplayer.com]

Rothmann-Makai Syndrome

A peripheral blood smear revealed anisopoikilocytosis and numerous Howell–Jolly bodies, indicating functional hyposplenism. [tropicalmedandhygienejrnl.net]

Cardiac Anomalies-Heterotaxy Syndrome

A blood test called a Howell Jolly Body test can determine whether the patient has a functioning spleen. [chd-uk.co.uk]

In those with asplenia or polysplenia diagnosed from ultrasound imaging, a blood film was also undertaken to look for Howell-Jolly bodies to ascertain if there was splenic [openheart.bmj.com]

Hereditary Neutrophilia

Any inclusion bodies (eg, Howell-Jolly bodies or malarial parasites) will also be noted. [patient.info]

Howell-Jolly bodies (small, round remnants of nuclear DNA inside cell): present in sickle cell anemia, hemolytic or megaloblastic anemias, and may be seen after a splenectomy [labtestsonline.org]

They include Howell-Jolly bodies, target cells, occasional nucleated RBCs, lymphocytosis, macrocytosis and acanthocytes. [patient.info]