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183 Possible Causes for Howell-Jolly Bodies

  • Splenectomy

    Often, Howell-Jolly bodies on peripheral blood film give an important clue to diagnosing hyposplenism.[] Splenectomy patients typically have Howell-Jolly bodies [5] [6] and less commonly Heinz bodies in their blood smears. [7] Heinz bodies are usually found in cases of G6PD ([] Its “pitting” function removes cellular inclusions like Heinz and Howell Jolly bodies without destruction of erythrocytes.[]

  • Autoimmune Hemolytic Anemia

    In both panels, HowellJolly bodies (asterisks) are indicative of asplenia. Table 1. Table 1.[]

  • Folate-Deficiency Anemia

    Multinucleate RBCs, abnormal karyorrhexis, increased pyknosis, and Howell-Jolly bodies ( right) may be seen.[]

  • Asplenia Syndrome

    Both presented with the severe cardiovascular anomalies found in this syndrome and had Howell-Jolly bodies in peripheral blood smears.[] Howell-Jolly bodies were found in their peripheral blood smear. The barium examinations of gastrointestinal tract showed intestinal obstruction and malrotation.[] Asplenia was suspected in one patient with combined immunodeficiency syndrome and 5 with congenital cardiac anomalies who had Howell-Jolly bodies on peripheral blood smears[]

  • Acute Leukemia

    Other features are; fragmentation, Howell-Jolly bodies, ring sideroblast, megaloblastic and dyserythropoiesis changes are common.[] . • Howell-Jolly bodies, ring sideroblast, megaloblastoid and dyserythropoietic changes • Coarse positivity of PAS • IHC: glycophorin A 33.[]

  • Thalassaemia-Haemoglobin C Disease

    […] poikilocytosis Target cells, ovalocytes, occasional fragmented red blood cells, basophilic stippling, increased polychromatophilic cells (but insufficient for the degree of anemia), Howell-Jolly[] -Heinz bodies -target cells -Howell-Jolly bodies -leukocytosis Sickle gene offers some protection against malaria What is the probable etiologic association between malaria[] Nucleated red cells and Howell-Jolly bodies are often present. The total WBC count is elevated to 12,000-20,000/cmm, with a predominance of neutrophils.[]

  • Anemia of Chronic Disease

    Pappenheimer bodies (iron granules) are variably present in the erythrocytes. Together with Howell-Jolly bodies, these reflect associated splenic dysfunction.[]

  • Sickle Cell Thalassemia Disease

    The peripheral blood smear results demonstrate normocytic, normochromic RBCs, the presence of nucleated RBCs (NRBCs), polychromasia, sickle cells, target cells, Howell-Jolly[] bodies, and Pappenheimer bodies.[]

  • Splenic Cyst

    On follow up the splenunculus had increased to normal splenic size and there was no evidence of Howell-Jolly bodies, suggesting normal splenic function.[]

  • Hereditary Koilonychia

    Abnormality in transfer of iron out of storage Reduced erythropoietin What are Howell-Jolly bodies are indicative of? Splenectomy or splenic atrophy (ex.[] Labs: Sickling test and Hb electrophoresis (look for HbS) PBS: Sickle cells, Howell-Jolly Bodies CBC: reticulocyte count What are the acute complications you can expect in[]

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