Hydrops Fetalis: Causes & Reasons

Possible Causes for Hydrops Fetalis

Hydrops fetalis (Fetal edema). A survey. Clin. Pediatr. 19 :334–339, 1980. [link.springer.com]

Hydrops can be divided into two major categories or types: immune hydrops - also called erythroblastosis fetalis - and non-immune hydrops. [usmleforum.com]

fetalis) and non-immune hydrops. [chw.org]

Gaucher Disease Type 2

Features of the perinatal lethal form can include extensive swelling caused by fluid accumulation before birth (hydrops fetalis); dry, scaly skin (ichthyosis) or other skin [slideshare.net]

fetalis ( 9745785 ) Physiopathology As a result, glucocerebroside accumulates principally in the phagocytic cells of the body but in some forms also in the central nervous [humpath.com]

Kupffer cells with striated or corrugated cytoplasm Ultrastructure gaucher cells with membrane-bound spindled, tubular inclusions Variants fetal Gaucher disease ( 9745785 ) hydrops [humpath.com]

Erythema Infectiosum

In pregnant women, however, it may be associated with fetal death and nonimmune hydrops fetalis. [ncbi.nlm.nih.gov]

Fetal complications include hydrops fetalis and intrauterine fetal demise. [bestpractice.bmj.com]

Hydrops fetalis and fetal death are complications of intrauterine parvovirus B19 infection. [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 7

Lysosomal storage diseases presenting as transient or persistent hydrops fetalis. Genet Couns 1991; 2: 227–32. [nature.com]

The most severe form manifests with hydrops fetalis in utero or in the early neonatal period. [journals.lww.com]

The severe form of MPS 7 can uniquely present at birth with hydrops fetalis (severe generalized edema). [ultragenyx.com]

Alpha-Thalassemia

fetalis called Hb Bart's hydrops fetalis. [flipper.diff.org]

They had a healthy non-thalassemic daughter from the first pregnancy but the second pregnancy ended unexpectedly with Hb Bart's hydrops fetalis. [ncbi.nlm.nih.gov]

This is one of the few cases with immune- and nonimmune-induced hydrops fetalis. [ncbi.nlm.nih.gov]

Pyruvate Kinase Deficiency

The authors report a case of hydrops fetalis due to severe pyruvate kinase deficiency, the most unusual clinical manifestation of this disease. [ncbi.nlm.nih.gov]

A hydrops fetalis and multicystic encephalomalacia were diagnosed in a neonate who was one of twins. The co-twin had died 5 weeks prior to delivery. [ncbi.nlm.nih.gov]

Prompt fetal diagnosis of pyruvate kinase deficiency is feasible and allows better management of hydrops fetalis due to this disorder. [ncbi.nlm.nih.gov]

Mucopolysaccharidosis

Keywords Live Birth Consanguineous Parent Mucopolysaccharidosis Hunter Syndrome Hydrops Fetalis These keywords were added by machine and not by the authors. [doi.org]

Three cases of non-immune hydrops fetalis born to consanguineous parents were thought to be due to beta-glucuronidase deficiency (MPS VII) on the basis of placental histology [ncbi.nlm.nih.gov]

The severe neonatal form is the most common type of this syndrome, characterized by hydrops fetalis (abnormal accumulation of fluid in various tissues of the body) and dysmorphic [news-medical.net]

Gaucher Disease

The most distinct features of perinatal-lethal Gaucher disease are non-immune hydrops fetalis, in utero fetal demise and neonatal distress. [ncbi.nlm.nih.gov]

A severe neonatal form can present in utero or perinatally with hydrops fetalis, congenital ichthyosis, or both. [emedicine.medscape.com]

Features of the perinatal lethal form can include extensive swelling caused by fluid accumulation before birth (hydrops fetalis); dry, scaly skin (ichthyosis) or other skin [ghr.nlm.nih.gov]

Mucolipidosis

Type II patients may also present with a congenital-onset form associated with ascites and hydrops fetalis prenatally, an infantile-onset form with the absence of symptoms [genedx.com]

The more severe subtype may induce hydrops fetalis or manifest soon after birth. Affected individuals present dysmorphic facial features reminiscent of Hurler syndrome. [symptoma.com]

Investigation of lysosomal storage diseases in nonimmune hydrops fetalis. Prenat Diagn. 2004 Aug. 24(8):653-7. [Medline]. Cibis GW, Tripathi RC, Harris DJ. [emedicine.medscape.com]

Noonan Syndrome

We report the case of a 4 y old female with a history of polyhydramnios, hydrops fetalis and bilateral congenital chylothorax. [raredisorders.imedpub.com]

We describe an infant prenatally diagnosed with hydrops fetalis ultimately found to have Noonan syndrome (NS). [ncbi.nlm.nih.gov]

Patient 2 (male) presented antenatally with hydrops fetalis that resolved after birth. [nature.com]

Mucopolysaccharidosis Type 4

The most severe form is characterized by hydrops fetalis and premature or very early death. [centogene.com]

In its rarest form, Sly syndrome causes children to be born with hydrops fetalis, in which extreme amounts of fluid are retained in the body. [en.wikipedia.org]

Mucopolysaccharidosis Type 1

In rare cases, some newborn infants with Sly syndrome may experience abnormal accumulation of fluid in various tissues of the body (hydrops fetalis). [rarediseases.org]

The most severe form is characterized by hydrops fetalis and premature or very early death. [centogene.com]

Congenital Syphilis

Early, intrauterine infection may not even be symptomatic at birth, but can also lead to preterm birth, hydrops fetalis or still birth. [symptoma.com]

Niemann-Pick Disease Type C

Pathogenic variants of the NPC1 or NPC2 genes yield highly variable phenotypes with a time course that ranges from fetal onset (i.e., hydrops fetalis) to progressive dementia [ncbi.nlm.nih.gov]

Hepatic insufficiency may cause hydrops fetalis. [symptoma.com]

The presence of perinatal hydrops fetalis or family history of a sibling with fetal ascites is a possible indicator of lysosomal storage disease. [hindawi.com]

Mirror Syndrome

Keywords Mirror syndrome Ballantyne syndrome Hydrops Fetalis anemia Maternal edema Authors Rafał Iciek Maciej Brązert Andrzej Klejewski Marek Pietryga Jacek Brązert [journals.viamedica.pl]

Since the most common cause for the development of hydrops fetalis is preeclampsia, we thought it could be important to identify clinical differences that could help in a [hindawi.com]

Keywords Mirror syndrome, Ballantyne syndrome, Hydrops Fetalis, anemia, Maternal edema About this article Title Ballantyne syndrome (the Mirror Syndrome) associated with severe [journals.viamedica.pl]

Generalized Arterial Calcification of Infancy

To our knowledge only few cases of GACI with hydrops fetalis were reported (1). Case report: We report on a female infant presented with hydrops fetalis. [thieme-connect.com]

All cases developed hydrops fetalis with cardiomegaly and polyhydramnios later in gestation, resulting in intrauterine fetal death in two cases and neonatal death immediately [ncbi.nlm.nih.gov]

[oncotarget.com] Fetus Hydrops Fetalis [doi.org] Fetus Hydrops Fetalis We report the case of a 32-week-old infant with hydrops fetalis and heart failure who died at 4 days [symptoma.com]

Generalized Arterial Calcification of Infancy 2

To our knowledge only few cases of GACI with hydrops fetalis were reported (1). Case report: We report on a female infant presented with hydrops fetalis. [thieme-connect.com]

[doi.org] Fetus Hydrops Fetalis We report the case of a 32-week-old infant with hydrops fetalis and heart failure who died at 4 days of age. [symptoma.com]

[oncotarget.com] Fetus Hydrops Fetalis [doi.org] Fetus Hydrops Fetalis We report the case of a 32-week-old infant with hydrops fetalis and heart failure who died at 4 days [symptoma.com]

Generalized Arterial Calcification of Infancy 1

To our knowledge only few cases of GACI with hydrops fetalis were reported (1). Case report: We report on a female infant presented with hydrops fetalis. [thieme-connect.com]

[doi.org] Fetus Hydrops Fetalis We report the case of a 32-week-old infant with hydrops fetalis and heart failure who died at 4 days of age. [symptoma.com]

[oncotarget.com] Fetus Hydrops Fetalis [doi.org] Fetus Hydrops Fetalis We report the case of a 32-week-old infant with hydrops fetalis and heart failure who died at 4 days [symptoma.com]

Short Rib-Polydactyly Syndrome Type Beemer-Langer

fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly. [bioportal.bioontology.org]

[…] bone, brain and kidney, and related phenotypes are macrocephaly and hypertelorism Disease Ontology : 12 A syndrome that results in multiple congenital anomalies, including hydrops [malacards.org]

fetalis X-ray Short horizontal ribs Trident-shaped pelvis Square iliac wings Horizontal acetabular roofs with medial spurs Proximal femoral ossification centers present at [fetalultrasound.com]

Hypercholesterolemia

Non-immune hydrops fetalis Non-immune hydrops fetalis is now the most common type of hydrops fetalis. [healthline.com]

What are the symptoms of hydrops fetalis? Symptoms of hydrops fetalis can occur during pregnancy or after the baby is born. [childrenshospital.org]

Nonimmune hydrops fetalis is more common. It accounts for up to 90% of cases of hydrops. [medlineplus.gov]

Hydropneumothorax

Non-immune hydrops fetalis Non-immune hydrops fetalis is now the most common type of hydrops fetalis. [healthline.com]

Nonimmune hydrops fetalis is more common. It accounts for up to 90% of cases of hydrops. [medlineplus.gov]

What are the symptoms of hydrops fetalis? Symptoms of hydrops fetalis can occur during pregnancy or after the baby is born. [childrenshospital.org]

Neonatal Respiratory Distress Syndrome

Non-immune hydrops fetalis Non-immune hydrops fetalis is now the most common type of hydrops fetalis. [healthline.com]

Nonimmune hydrops fetalis is more common. It accounts for up to 90% of cases of hydrops. [medlineplus.gov]

What are the symptoms of hydrops fetalis? Symptoms of hydrops fetalis can occur during pregnancy or after the baby is born. [childrenshospital.org]

Chylothorax

Keywords: Chylothorax, Hydrops fetalis, Octreotide, Preterm, Thoracostomy Introduction Chylothorax complicated by hydrops fetalis in a premature or term infant is an uncommon [ncbi.nlm.nih.gov]

A 35-week preterm who presented with massive congenital chylothorax complicated with hydrops fetalis. [jcnonweb.com]

Antenatal classification of hydrops fetalis. Obstet. Gynecol. 1992, 79, 256–259. [mdpi.com]

Hydrocephalus

What is hydrops fetalis? [childrenshospital.org]

Non-immune hydrops fetalis Non-immune hydrops fetalis is now the most common type of hydrops fetalis. [healthline.com]

Nonimmune hydrops fetalis is more common. It accounts for up to 90% of cases of hydrops. [medlineplus.gov]

Congenital Dyserythropoietic Anemia

Fetalis/diagnosis* Hydrops Fetalis/etiology* Hydrops Fetalis/therapy Infant Infant, Newborn Jaundice, Neonatal/diagnosis Jaundice, Neonatal/etiology Jaundice, Neonatal/therapy [ncbi.nlm.nih.gov]

Hydrops fetalis is rarely caused by congenital dyserythropoietic anemia (CDA). We report a patient with hydrops fetalis as a result of severe anemia. [ncbi.nlm.nih.gov]

Congenital dyserythropoietic anemia should be considered in the differential diagnosis of hydrops fetalis presenting with a very severe anemia and a skeletal abnormality of [ncbi.nlm.nih.gov]

Hemoglobinopathy

Of the 664 patients represented, 163 (24.5%) were beta-thalassemia major carriers, 68 (10.2%) were hemoglobin Bart's hydrops fetalis carriers and, in total, 361 (54.4%) had [ncbi.nlm.nih.gov]

The estimated numbers of pregnancies each year in the Meizhou region, in which the fetus would be at risk for β thalassemia major or intermedia, Bart's hydrops fetalis, and [ncbi.nlm.nih.gov]

Death occurs in utero from Hb Bart’s hydrops fetalis. [mlo-online.com]

Congenital Chylothorax

To discuss a range of management techniques and supportive therapies for hydrops fetalis and CC. [ncbi.nlm.nih.gov]

fetalis and CC.PubMed and CINAHL were searched using the terms "hydrops fetalis," "congenital," "chylothorax," "neonate," and "preterm." [scholars.duke.edu]

Congenital chylothorax is part of the differential diagnosis of nonimmune hydrops fetalis. [ncbi.nlm.nih.gov]

Thalassemia

KEYWORDS: Hb Bart’s hydrops fetalis; ultrasound; α-Globin gene; α-thalassemia (α-thal) [ncbi.nlm.nih.gov]

KEYWORDS: Direct whole blood PCR; Hemoglobin Bart’s hydrops fetalis; α0-thalassemia [ncbi.nlm.nih.gov]

Neonates with Hb Bart's hydrops fetalis usually die in the perinatal period. [orpha.net]

Thalassemia Minor

[…] thalassemia ( D56.3 ) hydrops fetalis due to isoimmunization ( P56.0 ) hydrops fetalis not due to immune hemolysis ( P83.2 ) Use Additional code, if applicable, for hydrops [icd10data.com]

The more severe type is known as hemoglobin Bart hydrops fetalis syndrome, which is also called Hb Bart syndrome or alpha thalassemia major. [icdlist.com]

Hydrops fetalis See Hb Barts hydrops fetalis syndrome under Hydrops fetalis. Prenatal diagnosis See Molecular genetics - genetic disorders. [rcpa.edu.au]

Beta Thalassemia

Alpha thalassemia major with hemoglobin Bart's usually results in fatal hydrops fetalis. [ncbi.nlm.nih.gov]

Additionally, hemoglobin H disease can cause: jaundice an extremely enlarged spleen malnourishment Hydrops fetalis Hydrops fetalis is an extremely severe form of thalassemia [healthline.com]

Alpha thalassemia major with Hb Bart's usually results in fatal hydrops fetalis. View/Print Table Table 1. [aafp.org]