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18 Possible Causes for Hyperactive Brainstem Reflexes, Spastic Paralysis, Weakness

  • Upper Motor Neuron Disease

    There are also rare progressive, autosomal recessive upper motor neuron degenerations (Infantile –Onset Ascending Hereditary Spastic Paralysis, Juvenile Primary Lateral Sclerosis[neuropathology-web.org] The muscles with lower motor neuron sign(weakness) usually relate with abnormal MEPs reponses.[e-acn.org] Signs: Upper Motor Neuron Lesion findings Muscle group weakness (not complete paralysis) Minimal muscle atrophy "Clasp-knife" spasticity Initial resistance to motion is strongest[fpnotebook.com]

  • Juvenile Primary Lateral Sclerosis

    Differential diagnosis Differential diagnoses include the allelic disorders juvenile amyotrophic lateral sclerosis and infantile-onset ascending hereditary spastic paralysis[orpha.net] They include: Stiffness, weakness and spasticity in your legs Tripping, difficulty with balance and clumsiness as the leg muscles weaken Weakness and stiffness progressing[health.vezeeta.com] […] tendon reflexes, and Babinski signs.[neuropathology-web.org]

  • Infantile-Onset Ascending Hereditary Spastic Paralysis

    Infantile Ascending Hereditary Spastic Paralysis - How is Infantile Ascending Hereditary Spastic Paralysis abbreviated?[acronyms.thefreedictionary.com] * Progressive muscle stiffness * Stiff leg muscles by age of 2 * Weak leg muscles by age of 2 * Arm weakness by age of 8 * Arm stiffness by age of 8 * Slow eye movements[checkorphan.org] […] tendon reflexes, and Babinski signs.[neuropathology-web.org]

  • Amyotrophic Lateral Sclerosis Type 5

    Differential diagnosis Differential diagnoses include juvenile primary lateral sclerosis and, to a lesser extent, infantile-onset ascending hereditary spastic paralysis (see[orpha.net] ALS5 patients suffer from slowly progressive muscle weakness beginning in their limbs and spreading to the bulbar muscles.[symptoma.com] […] tendon reflexes, and Babinski signs.[neuropathology-web.org]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Infantile-onset ascending hereditary spastic paralysis (IAHSP) is characterized by the following features [ Lesca et al 2003 ]: Onset of spasticity with increased reflexes[cmm.ucsd.edu] Four of the five affected patients had muscle weakness since age 3, strongly worsening during childhood and leading to generalized tetraplegia in adulthood.[ncbi.nlm.nih.gov] […] tendon reflexes, and Babinski signs.[neuropathology-web.org]

  • Progressive Muscular Atrophy

    In this latter class spastic paralysis precedes the wasting, and Charcot has applied the designation Amyotrophic lateral sclerosis to such cases.[chestofbooks.com] She developed muscle weakness of the distal part of the left lower extremity at age 42, followed by muscle weakness and atrophy of the right lower extremity and upper extremities[ncbi.nlm.nih.gov] […] tendon reflexes, and Babinski signs.[neuropathology-web.org]

  • Pseudobulbar Palsy

    […] neurons; characterized by speech and swallowing difficulties, emotional instability, and spasmodic, mirthless laughter. pseudobulbar palsy Pseudobulbar paralysis, spastic[medical-dictionary.thefreedictionary.com] There may also be neurological deficits in the limb - eg, increased tone, enhanced reflexes and weakness.[patient.info] brainstem reflexes (eg, jaw jerk), the dissociation of automatic and volitional movements of the bulbar muscles with preservation of automatic movements, and the absence[medlink.com]

  • Progressive Bulbar Palsy

    Synonym(s): spastic diplegia ; spastic paraplegia Erb-Duchenne paralysis - Synonym(s): Erb palsy[medical-dictionary.thefreedictionary.com] Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles.[icd9data.com] Pseudobulbar palsy is a clinical syndrome of dysarthria, dysphagia, a hyperactive gag reflex and labile emotional responses.[radiopaedia.org]

  • Motor Neuron Disease

    There are also rare progressive, autosomal recessive upper motor neuron degenerations (Infantile –Onset Ascending Hereditary Spastic Paralysis, Juvenile Primary Lateral Sclerosis[neuropathology-web.org] Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles.[ncbi.nlm.nih.gov] Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene. Am J Hum Genet 2002 ; 71 : 518 –27.[doi.org]

  • Amyotrophic Lateral Sclerosis Type 4

    Infantile-onset ascending spastic paralysis (IAHSP) [MIM:607225]: Characterized by progressive spasticity and weakness of limbs. {ECO:0000269 PubMed:12145748}.[genecards.org] […] tendon reflexes, and Babinski signs.[neuropathology-web.org] They may seek medical advice due to progressive distal limb weakness and subsequent muscle wasting.[symptoma.com]

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