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26 Possible Causes for Hyperactivity, Small Face, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    For example, many people affected by the disease have a small face and head. Sometimes they have a high forehead that slopes as well.[wisegeek.net] […] disorder Attention deficit Attention deficit disorder Attention deficit-hyperactivity disorder Attention deficits Childhood attention deficit/hyperactivity disorder [ more[rarediseases.info.nih.gov] This autosomal recessive disorder is characterized by variable degrees of intrauterine and postnatal growth retardation, microcephaly, mild mental retardation, hyperactivity[ncbi.nlm.nih.gov]

  • Seckel Syndrome

    General appearance of the patient was characterized by a small, narrow face and forehead, slightly beaked nose, midfacial hypoplasia, very stunted stature with microcephaly[termedia.pl] Most children with Seckel syndrome are "friendly and pleasant" but "often hyperkinetic (hyperactive) and easily distracted." This disease is genetic.[medicinenet.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Down Syndrome

    Morphological features (upslanting palpebral fissures, epicanthus, flat neck, round face, small nose, bilateral single palmar crease) can be mild and do not constitute a hallmark[orpha.net] In more rare cases, Down syndrome patients may be affected with hyperthyroidism, symptoms of which include breathing and sleeping difficulties, and hyperactivity.[symptoma.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Russell-Silver Syndrome

    The wide prominent forehead contrasts with the small, triangular face with a small pointed chin, a wide mouth with thin lips and down-turned corners, large eyes and bluish[orpha.net] As they get older, these infants/children may have altered behaviour, such as hyperactivity or, conversely, tiredness, as a symptom of their low blood sugar level •Face -[netmums.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Ring Chromosome 10

    , clinodactyly of V finger, normal mental/motor development, short attention span, hyperactive behaviour p22.3 q36.3 12431259 Edit 2 8922097_1 46, XY, r(7)(p22.3q36.3) [80%[chr7.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] In addition, the syndrome causes a prognathism, the face is long and small and the patient has large ears.[embryology.ch]

  • Atelosteogenesis Type 2

    Ethylmalonic Aciduria Excessive Daytime Sleepiness Exostoses, Multiple, Type II Extrapyramidal Movement Disorder Fabry Disease Faciogenital Dysplasia with Attention Deficit Hyperactivity[sequencing.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[thehealthscience.com]

  • Kleiner Holmes Syndrome

    ; High, flat forehead; Low frontal hairline; Maxillary hypoplasia; Facial asymmetry; Long and prominent ear crus; Small ears; Low-set ears; Apical cartilage deformity; Deafness[panelapp.genomicsengland.co.uk] Attention deficit problems – with or without hyperactivity, anxiety, and aggression – can be seen in almost 8 out of 10 children.[epilepsy.com] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov]

  • Craniofrontonasal Dysplasia

    The upper face (base of the nose to height of the commissure of the mouth) is relatively small compared with the width of the face (lateral points of zygoma).[nature.com] […] or malfunction, or hormonalHP:0001852Sandal gapMP:0020157abnormal behavioral response to alcoholany anomaly in the behavioral response induced by alcohol, such as induced hyperactivity[pediascape.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Short Stature due to Endocrine Disorder

    […] feet [ more ] 0001773 Small hand Disproportionately small hands 0200055 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Synophrys Monobrow Unibrow [ more ] 0000664[rarediseases.info.nih.gov] […] deficit disorder Attention deficit-hyperactivity disorder Attention deficits Childhood attention deficit/hyperactivity disorder [ more ] 0007018 Bilateral sensorineural hearing[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    The endocrine glands that are hyperactive in the McCune–Albright syndrome have autonomous function. 4 5 6 7 8 9 One explanation for the manifestations of the disease is that[nejm.org] space between the first and second toes.[medcraveonline.com] , and frontal bossing with a triangular face.[uniprot.org]

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