Hyperalgesia: Causes & Reasons

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Possible Causes for Hyperalgesia

Anxiety Disorder

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor. Proc Natl Acad Sci USA 98 : 9407–9412. [doi.org]

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor. [ncbi.nlm.nih.gov]

Actinic Keratosis

Actinic keratosis Other names Solar keratosis, senile keratosis (SK) Actinic keratosis seen on the back of the hands Specialty Dermatology Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis,[1][2] is a pre-cancerous[3] area of thick, scaly, or crusty skin.[4][5] The term actinic keratosis[…] [en.wikipedia.org]

Mixed Anxiety and Depressive Disorder

Abstract The aim of the present study was to evaluate the validity of mixed anxiety and depressive disorder (MADD) with reference to functional characteristics and symptomatic characteristics in comparison with anxiety disorders, depressive disorders, and groups showing subthreshold symptoms (exclusively[…] [ncbi.nlm.nih.gov]

Shoulder-Hand Syndrome

A subpopulation of patients was reevaluated for mechanical hyperalgesia after i.v. injection of 500 mg acetyl-salicylic acid. Hyperalgesia to heat was insignificant. [ncbi.nlm.nih.gov]

Pain and mechanical hyperalgesia are hallmarks of CRPS. [doi.org]

Hyperalgesia to heat was tested with a thermode providing feedback-controlled temperature increases. [ncbi.nlm.nih.gov]

Staphylococcus Aureus Infection

Result Filters Abstract Staphylococcus aureus strains that produce Panton-Valentine leukocidin are known to cause community infections. We describe an outbreak of skin abscesses caused by Panton-Valentine leukocidin-producing methicillin-susceptible S. aureus (clonal complex 121) in a professional rugby team in[…] [ncbi.nlm.nih.gov]

Acute Anxiety

INTRODUCTION: Anxiety disorders are associated with significant public health burden in young individuals. Cognitive-behavioural therapy (CBT) is the most commonly used psychotherapy for anxiety disorders in children and adolescents, but previous reviews were hindered by a limited number of trials with direct[…] [ncbi.nlm.nih.gov]

Complex Regional Pain Syndrome Type II

The two main symptoms seen in patients with CRPS are allodynia and hyperalgesia. [lapaindoc.com]

Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to any inciting event. 3. [medlink.com]

Hyperalgesia is when a normally painful stimulus becomes much more painful than would normally occur. [omegapainclinic.com]

Adiposis Dolorosa

To avoid exacerbating hyperalgesia, we utilized a touch-free method, which is delivered via a high-performance altitude simulator, the Cyclic Variations in Altitude Conditioning [dx.doi.org]

[…] disorder of painful nodular subcutaneous fat accompanied by fatigue, difficulty with weight loss, inflammation, increased fluid in adipose tissue (lipedema and lymphedema), and hyperalgesia [dx.doi.org]

Reflex Sympathetic Dystrophy

The serum concentration of noradrenaline was lower on the painful side than on the healthy side, and neurotropin, which has an antinociceptive effect to hyperalgesia, was [ncbi.nlm.nih.gov]

Reflex sympathetic dystrophy (RSD) or complex regional pain syndrome type 1, is characterized by spontaneous pain or allodynia and hyperalgesia disproportionate to the inciting [ncbi.nlm.nih.gov]

Continuing pain, allodynia (perception of pain from a nonpainful stimulus), or hyperalgesia (an exaggerated sense of pain)3. [slideshare.net]

Sleep Deprivation

Lack of sufficient sleep--a rampant problem among teens--appears to put adolescents at risk for cognitive and emotional difficulties, poor school performance, accidents and psychopathology, research suggests. BY SIRI CARPENTER Monitor staff On any given school day, teen-agers across the nation stumble out of[…] [web.archive.org]

Primary Erythromelalgia

/hyperalgesia. [ncbi.nlm.nih.gov]

/ hyperalgesia. [journals.lww.com]

This resulted in complete resolution of both allodynia and hyperalgesia. Dosage was increased to 1.8 mcg/die. [painmatters.wordpress.com]

Fibromyalgia

The benefit to both migraine and fibromyalgia from inhibiting ionotropic N-methyl-D-aspartate receptor activity implies that redundant hyperalgesia-related neuroplastic changes [web.archive.org]

Fibromyalgia syndrome (FMS) is a common chronic musculoskeletal pain disorder of unknown etiology and characterized by generalized body pain, hyperalgesia, and other functional [ncbi.nlm.nih.gov]

The potential contribution of insular dysfunction to the development of hyperalgesia has been demonstrated in rat models via local manipulations of dopaminergic, gamma-aminobutyric [ncbi.nlm.nih.gov]

Peripheral Sensory Neuropathy

Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J Neurosci. 1982;2(6):765-781. [clinicalpainadvisor.com]

hyperalgesia, pinprick hyperalgesia, and marked and more frequent DMA. [journals.lww.com]

There may be hyperalgesia, in which mild stimuli cause pain, and allodynia, in which ordinarily nonpainful stimuli, such as touch, cause pain. [courses.washington.edu]

Secondary Fibromyalgia

This can cause allodynia or hyperalgesia. In individuals with chronic pain, EEGs showed altered brain activity, suggesting pain-induced neuroplastic changes. [en.wikipedia.org]

[…] hypogonadism, infertility, impaired immune system, falls and fractures in older adults, neonatal abstinence syndrome, heart problems, sleep-disordered breathing, opioid-induced hyperalgesia [en.wikipedia.org]

Algophobia

This person will begin to anticipate the problems and experience the results before anything actually happens to them. [2] People suffering from this probably have hyperalgesia [en.wikipedia.org]

People suffering from this probably have hyperalgesia. [definitions.net]

Fear

Is an amygdala necessary to experience and perceive fear? Intriguing evidence comes from patient S.M. who lost her left and right amygdalae to disease. Initial testing suggested that S.M.'s most defining symptom was an inability to recognize fear in other people's facial expressions. A fascinating paper by Adolphs and[…] [ncbi.nlm.nih.gov]

Opioid Withdrawal

Withdrawal from opioids can be complicated by opioid-induced hyperalgesia, a paradoxical amplification of pain by opioids. [stke.sciencemag.org]

Hyperalgesia is a cardinal symptom of opioid withdrawal. [ncbi.nlm.nih.gov]

Symptoms of IT withdrawal were similar in all patients and included diuresis, agitation, hyperalgesia, mild diarrhea, yawning, and taste and smell aversion. [ncbi.nlm.nih.gov]

Brachioradial Pruritus

hyperalgesia) and 2 ) a slightly painful pin-prick stimulation is perceived as more painful around a focused area of inflammation (punctate hyperalgesia). [care.diabetesjournals.org]

Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia. Acta Derm Venereol 1999;79:118-21. 16. Astwazaturow M. [content.sciendo.com]

Additional features of the dermatologic condition may include localized burning, pain, tenderness, hyperalgesia, or dysesthesias. [lagunaskincenter.com]

Medial Medullary Syndrome

[…] ataxia, contralateral Horner’s syndrome and ipsilateral hyperalgesia of the body. [lecturio.com]

In the 1930s Lewis and Hardy conducted experimental work to explain the underlying mechanisms of hyperalgesia and hyperesthesia ( Lewis 1936 ; Hardy et al 1950 ). [medlink.com]

It manifests as triad of ipsilateral ataxia, ipsilateral Horner’s syndrome and ipsilateral hyperalgesia of the face. [lecturio.com]

Familial Episodic Pain Syndrome Type 3

Quantitative sensory testing demonstrated normal baseline sensory thresholds but an enhanced secondary hyperalgesia to punctate stimuli on treatment with mustard oil. [ncbi.nlm.nih.gov]

[…] system and heart plays a critical role in pain perception activation of ASIC3 and TRPV1 as well as enhanced SCN10A activity are essential for the development of long-lasting hyperalgesia [genatlas.medecine.univ-paris5.fr]

Remifentanil

Infusion rates greater than 0.2 μg.kg -1 .min -1 are characterised by lower mechanical/pressure/cold/pain thresholds, which suggests hyperalgesia. [ncbi.nlm.nih.gov]

BACKGROUND: Several studies indicate that remifentanil exposure may engender opioid-induced hyperalgesia. [ncbi.nlm.nih.gov]

Therefore, it is of interest to investigate other ways of preventing opioid-induced hyperalgesia. [clinicaltrials.gov]

Familial Episodic Pain Syndrome Type 1

Quantitative sensory testing demonstrated normal baseline sensory thresholds but an enhanced secondary hyperalgesia to punctate stimuli on treatment with mustard oil. [ncbi.nlm.nih.gov]

(100%) Stimulus Mechanical impact (Pin) stimuli May be associated with central sensitization Thermal hyperalgesia: Less common Position dependent amplification Allodynia [neuromuscular.wustl.edu]

QST revealed mechanical allodynia and heat-pain hyperalgesia at the site affected by CRPS. [ped-rheum.biomedcentral.com]

Familial Episodic Pain Syndrome Type 2

(100%) Stimulus Mechanical impact (Pin) stimuli May be associated with central sensitization Thermal hyperalgesia: Less common Position dependent amplification Allodynia [neuromuscular.wustl.edu]

QST revealed mechanical allodynia and heat-pain hyperalgesia at the site affected by CRPS. [ped-rheum.biomedcentral.com]

Chronic Pain Disorder

Hyperalgesia and allodynia may develop due to either repeated neuronal damage or sustained inflammatory processes. [uspharmacist.com]

You may hear this described in the following medical terms: hyperalgesia – feeling pain from pressure or temperature that would not normally be painful allodynia – experiencing [nhs.uk]

Melittin, a basic 26-amino-acid polypeptide that constitutes 40–60% of dry BV, seems to be the major pain-producing substance of BV, by which peripheral persistent pain and hyperalgesia [cureus.com]

Chronic Interstitial Cystitis

Segmental Hyperalgesia to Mechanical Stimulus in Interstitial Cystitis/Bladder Pain Syndrome - Evidence of Central Sensitization. J Urol. 2013 Dec 5. [Medline]. [emedicine.medscape.com]

Diabetic Polyneuropathy

The signs of damage to the peripheral neurons are hypoesthesia, hypoalgesia, hyperesthesia and hyperalgesia, decreased tendon reflexes, and, possibly, weakness and muscle [ncbi.nlm.nih.gov]

Most common form (typical): symmetric distal sensory or sensorimotor polyneuropathy Distressing numbness, tingling, pain of legs/feet, usually worse at night; allodynia; hyperalgesia [5minuteconsult.com]

Allodynia and hyperalgesia may be present. [pijn.com]

Erythromelalgia

[…] had hyperalgesia on testing. [ncbi.nlm.nih.gov]

A rare disorder most common in middle age, characterized by paroxysmal attacks of severe burning pain, reddening, hyperalgesia, and sweating, involving one or more extremities [medical-dictionary.thefreedictionary.com]

The disappearance of tenderness over erythematous area (allodynia/hyperalgesia symptoms) shows that pregabalin is useful for managing neuropathic pain mechanism. [chanrejournals.com]

Iatrogenic Opiate Addiction

In fact, growing evidence suggests that long-term treatment with opioids may induce hyperalgesia, an increase in pain sensitivity as a result of the chronic administration [drugabuse.gov]

In some patients, the repeated use of opioids can also lead to hyperalgesia, which is a state of heightened pain sensitivity. 37,38 In the clinical context, hyperalgesia can [nejm.org]

Hyperalgesia: an emerging iatrogenic syndrome. I Pain Symptom Manage 2003;26:769-775. American Psychiatric Association. [jenniferschneider.com]

Diabetic Pseudotabes

Tests of tactile and thermal hyperalgesia are additional markers of neural hyperactivity that are useful for diagnosis and disease management. [paperity.org]

[…] glycemic control Intense neuropathic pain Occurs in men with Type II diabetes that is poorly controlled Anorexia and weight loss is common Clinical presentation: Severe hyperalgesia [neurodiffdx.com]

Nevertheless, there is evidence suggesting that small-fiber neuropathy may occur early, often presenting with pain and hyperalgesia before sensory deficits or nerve conduction [oncohemakey.com]

Sodium Chloride

Graft Failure / Ischemia-Reperfusion Injury 1 3CompletedPrevention Hereditary Angioedema 1 3CompletedPrevention Hernia, Femoral / Inguinal Hernias 1 3CompletedPrevention Hyperalgesia [drugbank.ca]

Syndrome (RDS) 1 3TerminatedTreatment Confusion and disorientation / Delirium / Postoperative / Psychomotor 1 3TerminatedTreatment Crohn's Disease (CD) 1 3TerminatedTreatment Hyperalgesia [drugbank.ca]

Available CompletedHealth Services Research Asthma Bronchial 1 Not Available CompletedHealth Services Research Bronchoscopy 1 Not Available CompletedHealth Services Research Hyperalgesia [drugbank.ca]