Possible Causes for hyperalgesia Actinic Keratosis Eryfotona AK-NMSC (ISDIN Spain) is a film-forming medical device in cream or fluid formulation containing the DNA-repair enzyme photolyase and high-protection UV filters in liposomes (repairsomes) indicated in the treatment of cancerization field in patients with actinic keratosis (AK) or non-melanoma skin cancer[…] [ncbi.nlm.nih.gov] Anxiety Disorder Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor. [ncbi.nlm.nih.gov] Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor. Proc Natl Acad Sci USA 98 : 9407–9412. [doi.org] Mixed Anxiety and Depressive Disorder BACKGROUND: Mixed anxiety and depressive disorder (MADD) is common yet ill-defined, with little known about outcomes. AIMS: To determine MADD outcomes over 1 year. METHOD: We recruited 250 adults attending seven London general practices with mild-moderate distress. Three groups were defined using a diagnostic[…] [ncbi.nlm.nih.gov] Hyperesthetic Thalamic Pain Syndrome Hyperesthesia is further divided into hyperalgesia and allodynia. [brainscape.com] (100%) Stimulus Mechanical impact (Pin) stimuli May be associated with central sensitization Thermal hyperalgesia: Less common Position dependent amplification Allodynia [neuromuscular.wustl.edu] Hyperalgesia is when a normally painful stimulus becomes much more painful than would normally occur. [omegapainclinic.com] Hysterical Neurosis Abstract Hysterical neurosis, though infrequently diagnosed in the West, is still one of the commonest mental disorders in India. In this study, 38 women with an index diagnosis of hysterical neurosis were evaluated after a period of 5 years; 63% of the patients remained totally asymptomatic. The premorbid hysterical[…] [ncbi.nlm.nih.gov] Shoulder-Hand Syndrome A subpopulation of patients was reevaluated for mechanical hyperalgesia after i.v. injection of 500 mg acetyl-salicylic acid. Hyperalgesia to heat was insignificant. [ncbi.nlm.nih.gov] Pain and mechanical hyperalgesia are hallmarks of CRPS. [doi.org] Hyperalgesia to heat was tested with a thermode providing feedback-controlled temperature increases. [ncbi.nlm.nih.gov] Staphylococcus Aureus Infection Result Filters Abstract Staphylococcus aureus strains that produce Panton-Valentine leukocidin are known to cause community infections. We describe an outbreak of skin abscesses caused by Panton-Valentine leukocidin-producing methicillin-susceptible S. aureus (clonal complex 121) in a professional rugby team in[…] [ncbi.nlm.nih.gov] Acute Anxiety INTRODUCTION: Anxiety disorders are associated with significant public health burden in young individuals. Cognitive-behavioural therapy (CBT) is the most commonly used psychotherapy for anxiety disorders in children and adolescents, but previous reviews were hindered by a limited number of trials with direct[…] [ncbi.nlm.nih.gov] Fibromyalgia The benefit to both migraine and fibromyalgia from inhibiting ionotropic N-methyl-D-aspartate receptor activity implies that redundant hyperalgesia-related neuroplastic changes [web.archive.org] Fibromyalgia syndrome (FMS) is a common chronic musculoskeletal pain disorder of unknown etiology and characterized by generalized body pain, hyperalgesia, and other functional [ncbi.nlm.nih.gov] The potential contribution of insular dysfunction to the development of hyperalgesia has been demonstrated in rat models via local manipulations of dopaminergic, gamma-aminobutyric [ncbi.nlm.nih.gov] Complex Regional Pain Syndrome Type II Complex regional pain syndrome (CRPS) is a well-known clinical entity, first described in the 1800s, consisting of pain, hyperalgesia, edema, and sudomotor changes either [ncbi.nlm.nih.gov] Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to any inciting event. 3. [medlink.com] The two main symptoms seen in patients with CRPS are allodynia and hyperalgesia. [lapaindoc.com] Reflex Sympathetic Dystrophy The serum concentration of noradrenaline was lower on the painful side than on the healthy side, and neurotropin, which has an antinociceptive effect to hyperalgesia, was [ncbi.nlm.nih.gov] Reflex sympathetic dystrophy (RSD) or complex regional pain syndrome type 1, is characterized by spontaneous pain or allodynia and hyperalgesia disproportionate to the inciting [ncbi.nlm.nih.gov] This is followed by mechano-hyperalgesia, mechano-allodynia, and cold-allodynia that lasted for at least 1 month. [ncbi.nlm.nih.gov] Adiposis Dolorosa To avoid exacerbating hyperalgesia, we utilized a touch-free method, which is delivered via a high-performance altitude simulator, the Cyclic Variations in Altitude Conditioning [ncbi.nlm.nih.gov] […] disorder of painful nodular subcutaneous fat accompanied by fatigue, difficulty with weight loss, inflammation, increased fluid in adipose tissue (lipedema and lymphedema), and hyperalgesia [ncbi.nlm.nih.gov] Sleep Deprivation This case report describes a generalized seizure associated with sustained-release bupropion use and sleep deprivation. The subject, a 31-year-old female smoker, was participating in a clinical trial evaluating an investigational medication for smoking cessation that used sustained-release bupropion as an active[…] [ncbi.nlm.nih.gov] Primary Erythromelalgia /hyperalgesia. [ncbi.nlm.nih.gov] / hyperalgesia. [journals.lww.com] This resulted in complete resolution of both allodynia and hyperalgesia. Dosage was increased to 1.8 mcg/die. [painmatters.wordpress.com] Opioid Withdrawal Abstract Hyperalgesia often occurs in opioid-induced withdrawal syndrome. [ncbi.nlm.nih.gov] Hyperalgesia is a cardinal symptom of opioid withdrawal. [ncbi.nlm.nih.gov] Withdrawal from opioids can be complicated by opioid-induced hyperalgesia, a paradoxical amplification of pain by opioids. [stke.sciencemag.org] Neuropathy hyperalgesia). [practicalpainmanagement.com] Hyperalgesia is an extreme sensitivity to something slightly painful to others. An unusually low sensation to hot or cold is called hypoesthesia. [spine-health.com] Examination often reveals allodynia (perception of nonpainful stimuli as being painful), hyperalgesia (perception of painful stimuli as being more painful than expected), [mdedge.com] Whiplash Injury Moderate relationships were found between hyperalgesia and CRP at both time points and between hyperalgesia and IL-1β 3 months post injury. [ncbi.nlm.nih.gov] […] with high initial neck pain intensity and neck-related disability, posttraumatic stress symptoms, pain catastrophizing, and, to a lesser extent, low self-efficacy and cold hyperalgesia [ncbi.nlm.nih.gov] These include pain and/or disability levels, neck range of movement, cold and mechanical hyperalgesia and psychological factors of recovery beliefs/expectations, post-traumatic [ncbi.nlm.nih.gov] Peripheral Neuropathy A 12-year-old girl presented with talipes equinus of both legs, attenuation of upper and lower limb tendon reflexes, thermal hyperalgesia, and reduction of vibratory sensation [ncbi.nlm.nih.gov] Neuroreport 9 : 243 -247, 1998 Rodella L, Rezzani R, Corsetti G, Bianchi R: Nitric oxide involvement in the trigeminal hyperalgesia in diabetic rats. [clinical.diabetesjournals.org] 신경병 통증이 다른 통증과 구분되는 증상은 이질통(allodynia)과 통각과민(hyperalgesia)이다. [ekjm.org] Irritable Bowel Syndrome RESULTS: The viscerosomatic referral pain pattern resulting from rectal distention was consistent with spinal hyperalgesia. [ncbi.nlm.nih.gov] Coutinho et al. ( 30 ) have shown that deprived rats exhibit visceral hyperalgesia and cutaneous hypoalgesia under baseline conditions, as well as visceral hyperalgesia and [doi.org] RESULTS: WAS exposure established an appropriate model of IBS in mice, with symptoms of visceral hyperalgesia and diarrhea. [ncbi.nlm.nih.gov] Diabetic Polyneuropathy The signs of damage to the peripheral neurons are hypoesthesia, hypoalgesia, hyperesthesia and hyperalgesia, decreased tendon reflexes, and, possibly, weakness and muscle [ncbi.nlm.nih.gov] Most common form (typical): symmetric distal sensory or sensorimotor polyneuropathy Distressing numbness, tingling, pain of legs/feet, usually worse at night; allodynia; hyperalgesia [5minuteconsult.com] Allodynia and hyperalgesia may be present. [pijn.com] Hypersensitivity Visceral hypersensitivity (visceral hyperalgesia) is the term used to describe the experience of pain within the inner organs (viscera) at a level that is more intense than [verywellhealth.com] Individuals with FM have alterations in brain structure, function, and neurochemistry that are thought to lead to the hyperalgesia and chronic pain commonly reported in this [nature.com] IBS is unlike other forms of bowel discomfort in that it is characterized by hyperalgesia (an abnormally intensified pain sensation) and allodynia (a painful sensation to [verywellhealth.com] Chronic Pelvic Pain Syndrome Functional bowel disorders and the visceral hyperalgesia hypothesis. Pain Research and Clinical Management 1993;9:3–28. Hightower NC, Roberts JW. [sti.bmj.com] [Crossref] Giamberardino MA, Costantini R, Affaitati G, Fabrizio A, Lapenna D, et al. (2010) Viscero–visceral hyperalgesia: characterization in different clinical models. [oatext.com] […] peripheral and central sensitisation and fit with a diagnosis of chronic pain are:13 Allodynia – a painful response to a stimulus that is not normally considered painful Hyperalgesia [bpac.org.nz] Postherpetic Neuralgia Hyperalgesia, allodynia, and "dysesthesia" often add to the discomfort for patients. 5 Diagnostics The diagnosis is determined by patient history and clinical presentation [flexikon.doccheck.com] An 80-year-old female diagnosed with PHN presented with severe left intercostal allodynia and hyperalgesia up to the root of the fourth to tenth thoracic dermatome. [ncbi.nlm.nih.gov] According to the proposed models, PHN pain might be associated with nociceptive deafferentation, and peripheral (heat hyperalgesia) or central sensitization (allodynia). [ncbi.nlm.nih.gov] Temporomandibular Joint Disorder TMJD vs. healthy controls) differences in hyperalgesia and temporal summation (TS) of heat pain. [ncbi.nlm.nih.gov] The association of PI and hyperalgesia at a nonorofacial site suggests that PI may be linked with central sensitivity and could play an etiologic role in idiopathic pain disorders [ncbi.nlm.nih.gov] Central Sensatisation is sensatisation of the dorsal horn and central structures that causes secondary hyperalgesia in the uninjured tissue around the injured site. 3. [physio-pedia.com] Sunburn Primary hyperalgesia in UVB-irradiated skin and secondary hyperalgesia in adjacent nonirradiated skin were studied in 22 healthy subjects 24h after irradiation with UVB at [ncbi.nlm.nih.gov] Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation. Pain. 2010 Jul;150(1):141-52. [PubMed: 20478657] 10. [ncbi.nlm.nih.gov] The time course of hyperalgesia over 96 h was studied in a subgroup of 12 subjects. [ncbi.nlm.nih.gov] Erythromelalgia […] had hyperalgesia on testing. [ncbi.nlm.nih.gov] A rare disorder most common in middle age, characterized by paroxysmal attacks of severe burning pain, reddening, hyperalgesia, and sweating, involving one or more extremities [medical-dictionary.thefreedictionary.com] Gould III, Ranolazine Attenuation of CFA‐induced Mechanical Hyperalgesia, Pain Medicine, 11, 1, (119-126), (2010). P. S. Mortimer, K. G. Burnand and H. A. M. [dx.doi.org] Insomnia However, previous studies have reported that sleep deprivation and interruption of slow wave sleep can reduce pain threshold and cause hyperalgesia [33, 34]. [ncbi.nlm.nih.gov] Ganglion Cyst Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia. [academic.oup.com] […] surface, causing ectopic and sustained firing.4 Such sustained DRG discharges have been linked to sensitization of the spinal dorsal horn cells and the resulting state of hyperalgesia [academic.oup.com] […] nociceptive pathways, resulting in central sensitization; this may manifest as pain hypersensitivity, in particular dynamic tactile allodynia, secondary punctate or pressure hyperalgesia [academic.oup.com] Dermatitis hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). [en.wikipedia.org] Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist [en.wikipedia.org] Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked [en.wikipedia.org] Chronic Fatigue Syndrome Various tissues are affected by generalised hyperalgesia: the skin, muscle tissue and the lungs. [ncbi.nlm.nih.gov] There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between [ncbi.nlm.nih.gov] Hyperalgesia is believed to be a factor in both fibromyalgia and chronic fatigue syndrome. [verywellhealth.com]
