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117 Possible Causes for Hyperalgesia, Hyperesthesia

  • Sunburn

    The finding of cold hyperalgesia and cold hyperesthesia is new in this model.[ncbi.nlm.nih.gov] Primary hyperalgesia in UVB-irradiated skin and secondary hyperalgesia in adjacent nonirradiated skin were studied in 22 healthy subjects 24h after irradiation with UVB at[ncbi.nlm.nih.gov] Within the sunburn area, cold hyperesthesia (P .01), profound generalized hyperalgesia to heat (P .001), cold (P .05), pinprick and pressure (P .001), and mild dynamic mechanical[ncbi.nlm.nih.gov]

  • Hyperesthetic Thalamic Pain Syndrome

    Hyperesthesia Symptoms As aforementioned, in cutaneous hyperesthesia, the skin reacts overtly to any type of stimuli causing an increase in pain and tenderness.[patienthelp.org] Hyperesthesia is further divided into hyperalgesia and allodynia.[brainscape.com] Current Knowledge The most common cause of hyperesthesia is peripheral neuropathy, such as might occur with diabetes or chronic alcohol abuse.[link.springer.com]

  • Reflex Sympathetic Dystrophy

    Reflex sympathetic dystrophy is characterized by constant burning pain and hyperesthesia in an extremity. Lower extremities are usually affected.[ncbi.nlm.nih.gov] The serum concentration of noradrenaline was lower on the painful side than on the healthy side, and neurotropin, which has an antinociceptive effect to hyperalgesia, was[ncbi.nlm.nih.gov] After arthrocentesis, dusky discoloration, edema, hyperesthesia, and decreased range of motion of the left knee and entire distal extremity were noted.[ncbi.nlm.nih.gov]

  • Vulvodynia

    Vulvodynia often occurs with unexplained vulvar pain and hyperesthesia, sexual dysfunction, and psychological disability, lacking an organic or microbiological substrate.[ncbi.nlm.nih.gov] Characterization of the effects of gabapentin and 3-isobutyl-γ-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology 1998; 88: 196–205. 17.[journals.lww.com] The effect of intrathecal gabapentin and 3-isobutyl γ-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg 1998; 86: 348–54. 7.[journals.lww.com]

  • Arachnoiditis

    Predominantly in Japan Clinical features Myelopathy Dose: Oral intake of 2 g/day for 3 weeks Onset: Numbness & pain in legs Clinical Sensation loss: Especially vibration Hyperesthesia[neuromuscular.wustl.edu] Large doses of opiates, that can cause hyperalgesia, hypersensitivity and tachyphylaxis, and lead to dependence, should be discouraged.[orpha.net] […] antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. – PubMed – NCBI Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia[accurateclinic.com]

  • Burn Injury

    Symptoms include hyperesthesia, mild pain, and tingling. Healing typically takes 3 to 6 days.[journals.lww.com] Gabapentin has established efficacy in the reduction of burn-induced hyperalgesia and allodynia in animal and human experimental burn models.[ncbi.nlm.nih.gov] Hyperalgesia can also cause automatic pain (pain without apparent cause) and can last from a few minutes up to several hours.[medbc.com]

  • Spinal Cord Metastasis

    […] significant history of a high-grade urothelial carcinoma who presented with progressive back pain and concomitant weakness, grade 3-4/5 proximally and 0-1/5 distally, and distal hyperesthesia[ncbi.nlm.nih.gov] […] high-grade urothelial carcinoma who presented with progressive back pain and concomitant weakness, grade 3-4/5 proximally and 0-1/5 distally, and distal hyperesthesia and hyperalgesia[ncbi.nlm.nih.gov]

  • Cervicogenic Headache

    […] patients with or without CEH was the lateralization of pressure hyperalgesia to the painful side of the head of CEH patients, accompanied by cold as well as warm relative hyperesthesia[ncbi.nlm.nih.gov] Older women with cervicogenic headache have localized pain sensitivity to cold stimuli, suggesting peripheral mechanisms underlie the hyperalgesia.[ncbi.nlm.nih.gov] Needle position for greater occipital block An effective method of detecting occipital neuralgia or cervicogenic headache caused by hyperalgesia of the occipital nerve is[practicalpainmanagement.com]

  • Zolmitriptan

    The most commonly reported adverse events were taste disturbance, paresthesia, hyperesthesia, headache, and nasal/throat discomfort.[ncbi.nlm.nih.gov] Moreover, electrically induced pinprick hyperalgesia was significantly decreased by zolmitriptan compared with placebo (F   6.243; p   0.017).[ncbi.nlm.nih.gov] Other side effects include: dizziness, drowsiness, hyperesthesia, jaw pain, nausea, neck pain, paresthesia, sore throat, flushing sensation, local pain, and sensation of cold[drugs.com]

  • Eletriptan

    Infrequent were abnormal dreams, agitation, anxiety, apathy, ataxia, confusion, depersonalization, depression, emotional lability, euphoria, hyperesthesia, hyperkinesia, incoordination[dailymed.nlm.nih.gov] Rare were abnormal gait, amnesia, aphasia, catatonic reaction, dementia, diplopia, dystonia, hallucinations, hemiplegia, hyperalgesia, hypokinesia, hysteria, manic reaction[dailymed.nlm.nih.gov]

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