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45 Possible Causes for Hyperbilirubinemia, Onset in First Weeks or Months of Life

  • Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] We believe our patient’s persistent direct hyperbilirubinemia with biopsy-confirmed cholestasis was also likely related to his AHC.[pediatrics.aappublications.org] […] cholesterol can no longer be hepatically excreted in the bile, its levels can build up manifesting as hypercholesterolemia and can manifest as clinically as xanthomas Conjugated Hyperbilirubinemia[pathwaymedicine.org]

  • Neonatal Sepsis

    The incidence rate of hyperbilirubinemia due to infection is unknown (7,8).[ijp.mums.ac.ir] Early-onset sepsis is seen in the first week of life. Occurs after 1 week and before 3 months of age.[omicsonline.org] Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov]

  • Intrahepatic Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution[ncbi.nlm.nih.gov] Pape, “Sickle Cell Disease, Extreme Hyperbilirubinemia, and Pericardial Tamponade: Case Report and Review of the Literature,” Critical Care Medicine, Vol. 30, No. 10, 2002[dx.doi.org]

  • Sepsis

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov] Hyperbilirubinemia did not return in 3 months.[ncbi.nlm.nih.gov] […] without a qSOFA score  2 because different forms of organ dysfunction may be present than are assessed using the qSOFA, such as hypoxemia, renal failure, coagulopathy, or hyperbilirubinemia[doi.org]

  • Sepsis in Premature Infants

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov] Other signs and symptoms include lethargy, temperature instability, hyperbilirubinemia, bradycardia, seizures and acidosis.[uichildrens.org] Trimethoprim-sulfamethoxazole should not be used if hyperbilirubinemia and kernicterus are of concern in the newborn.[emedicine.medscape.com]

  • Streptococcal Septicemia

    […] are infected within the first week of life, it is called early-onset GBS disease.[sepsis.org] […] hydroxyprolinaemia (Br Eng) or hydroxyporlinemia (Am Eng) hyperaemia (Br Eng) or hyperemia (Am Eng) hyperamylasaemia (Br Eng) or hyperamylasemia (Am Eng) hyperbilirubinaemia (Br Eng) or hyperbilirubinemia[wordlister.blogspot.com] […] homocystinaemia (Br Eng) hydremia (Am Eng) or hydraemia (Br Eng) hydroxyprolinemia (Am Eng) or hydroxyporlinaemia (Br Eng) hyperamylasemia (Am Eng) or hyperamylasaemia (Br Eng) hyperbilirubinemia[wordlister.blogspot.com]

  • Laryngeal Stridor

    Congenital abnormalities of the upper airway typically present in the first few weeks to months of life and are the most common causes of stridor (87%).[medicine.uiowa.edu] […] headache, memory impairment, cerebrospinal bleeding, hyponatremia, syndrome of inappropriate antidiuretic hormone secretion, nausea and vomiting, uterine rupture, neonatal hyperbilirubinemia[ccforum.biomedcentral.com] It may begin immediately after birth or any time within the first two weeks of life and may worsen over the first six months of life, making it an important consideration[ahcmedia.com]

  • Hemorrhagic Disease of the Newborn

    It usually occurs from the second day of life to the end of the first week; however, it can occur during first month and sometimes overlaps with late-onset vitamin K deficiency[emedicine.com] […] gestational age infant (LGA) Physical maturity Pathology of prematurity Gross appearance of premature infant Difficulties in maintaining homeostasis Thermoregulation Hypoglycemia Hyperbilirubinemia[atlases.muni.cz] Vitamin K1 has been associated with hyperbilirubinemia only in extremely high doses (25 – 30mg).[med.stanford.edu]

  • Neonatal Infection

    […] low-risk for having a serious bacterial illness: [2] generally well-appearing previously healthy full term (at 37 weeks gestation) no antibiotics perinatally no unexplained hyperbilirubinemia[en.wikipedia.org] Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[mountsinai.org] Care Plans Cleft Palate and Cleft Lip 6 Care Plans Dysfunctional Labor (Dystocia) 4 Care Plans Elective Termination 6 Care Plans Gestational Diabetes Mellitus 4 Care Plans Hyperbilirubinemia[nurseslabs.com]

  • Early Infantile Epileptic Encephalopathy Type 2

    Clinical description Onset of EIEE occurs within the first 3 months of life but some present within the first few weeks after birth.[orpha.net] (C0117) was delivered at the age of 28 weeks and was diagnosed with hyperbilirubinemia, at the age of one year and one month his DQ indicates moderate ID. (2).[nature.com]

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