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12 Possible Causes for Hypercalcemia, Leukocyte Alkaline Phosphatase Decreased, Occult Malignancy

  • Bronchogenic Carcinoma

    Hypercalcemia of malignancy is the most common cause of hypercalcemia in hospitalized patients.[journals.lww.com] […] metastases from lung cancer may present clinically or as a finding at autopsy. [3] Clinically they present with symptoms of colonic obstruction, lower gastrointestinal bleed (occult[jpgmonline.com] Humoral hypercalcemia, caused by tumor production of parathyroid-hormone-related protein, is the most common type of hypercalcemia of malignancy.[journals.lww.com]

  • Non-Hodgkin Lymphoma

    Other features include anemia; hypercalcemia; and renal insufficiency. A malignant neoplasm of the bone marrow composed of plasma cells.[icd9data.com] Lymphoma Adult T-cell leukemia/lymphoma (ATL) is caused by infection with the retrovirus human T-lymphotrophic virus 1 and is frequently associated with lymphadenopathy, hypercalcemia[web.archive.org] A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia[icd9data.com]

  • Adenocarcinoma of the Breast

    Diffuse Worse during the late luteal phase of menstrual cycle Subsides with onset of menstruation Focal SOB/dyspnea Metastatic disease to the lungs Bone pain and symptoms of hypercalcemia[pathophys.org] About 10% of patients with bone metastases eventually develop hypercalcemia, which can also be treated with IV bisphosphonates.[merckmanuals.com]

  • Renal Cell Carcinoma

    Google Scholar 7 : A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 1987 ; 237 : 893.[doi.org] We describe a unique case of subcutaneous metastasis of sarcomatoid renal cell carcinoma which was the first manifestation of the occult malignancy.[ncbi.nlm.nih.gov] Hypercalcemia, 3. Hypertension, 4. Hepatic dysfunction, 5. Feminization or masculinization, 6. Cushing syndrome, 7. Eosinophilia, 8. Leukemoid reactions, and 9.[slideshare.net]

  • Metastatic Adenocarcinoma of the Breast

    Other complications that can arise from bone metastases include the surgical treatment for fractures, hypercalcemia (abnormally high levels of calcium), and spinal cord compression[imaginis.com] Diffuse Worse during the late luteal phase of menstrual cycle Subsides with onset of menstruation Focal SOB/dyspnea Metastatic disease to the lungs Bone pain and symptoms of hypercalcemia[pathophys.org] The bones are a very common site of metastatic disease from breast cancer, and bone metastases can cause severe pain, hypercalcemia and pathologic fracture.[en.wikipedia.org]

  • Hodgkin Lymphoma

    This increase in blood calcium, or hypercalcemia, causes subtle signs that are important for both Hodgkin's survivors and their families to recognize.[livestrong.com] But lethargy and sadness can be mistaken for depression, and confusion can be written off as forgetfulness or distraction, when these are additional signs of hypercalcemia[livestrong.com] Abdominal pain, nausea and vomiting, constipation, frequent urination, muscle weakness or aches are symptoms listed by MayoClinic.com as easy-to-spot signs of hypercalcemia[livestrong.com]

  • Metastatic Renal Cell Carcinoma

    The third patient developed grade 4 hypercalcemia due to RPD on day 3.[ncbi.nlm.nih.gov] Hypercalcemia, hypertension and thromboembolism may contribute to mRCC-related morbidity and may thus require additional, symptomatic therapy.[symptoma.com] Biological status: anemia (hemoglobin 8.8 g/dl), hypercalcemia (serum calcium 12.4 mg/dl), creatinine 2.4 mg/dl, BUN 109 mg/dl, LDH 1448 U/L, clearence to creatinine 41 ml[medichub.ro]

  • Cecal Adenocarcinoma

    A few cases of ASC of the colon have been found in the setting of hypercalcemia, which is thought to be a paraneoplastic phenomenon [ 2 , 11 , 12 ].[omicsonline.org] Most importantly, for patients with blood cultures that grow C. septicum , a comprehensive search for occult malignancy is imperative, especially for adenocarcinomas in the[acgcasereports.gi.org] According to this definition, the sign may be present with or without occult malignancy and is detectable on history and physical examination alone.[jhoonline.biomedcentral.com]

  • Rathbun Syndrome

    […] alkaline phosphatase level and increased phosphoethanolamine (now considered to be a non-specific finding) and inorganic pyrophosphate blood and urinary levels, as well as hypercalcemia[symptoma.com] […] or overt malignancy and other thrombophilic states. 6 – 10 PATHOGENESIS Effort thrombosis usually follows sporting activities, such as wrestling, playing ball, gymnastics[ncbi.nlm.nih.gov] , and perhaps calcitonin, but hypercalcemia is often difficult to manage as it occurs in severely affected patients.[rarediseases.org]

  • Malignant Melanoma

    The patient's hypercalcemia was controlled and muscle strength was partially recovered.[ncbi.nlm.nih.gov] FM Solivetti, SA Di Luca, G Pirozzi, etal: Sonographic evaluation of clinically occult in-transit and satellite metastases from cutaneous malignant melanoma Radiol Med (Torino[doi.org] Striking differences were noted in a small subset of patients who had occult nodal metastases treated with IFN versus control.[emedicine.com]

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