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970 Possible Causes for Hypercalcemia, Splenomegaly

  • Malignant Neoplasm

    Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs). We report a case of colorectal carcinoma as a SMN, following treatment for rhabdomyosarcoma. The patient was[…][]

  • Hypervitaminosis A

    Hypervitaminosis A has been associated with hypercalcemia.[] Further systemic consequences of HA are hepatotoxicity, hepatomegaly, splenomegaly, ascites, migratory arthritis, and hepatic hydrothorax.[] Splenomegaly. Raised intracranial pressure. Stupor. Limited body movement. Cirrhosis of liver.[]

  • Hodgkin's Disease

    This increase in blood calcium, or hypercalcemia, causes subtle signs that are important for both Hodgkin's survivors and their families to recognize.[] The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[] Hodgkin's lymphoma symptoms include night sweats, enlarged lymph nodes, splenomegaly, and back pain. Treatment entails radiotherapy or chemotherapy.[]

  • Sarcoidosis

    A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia.[] Abdomen Check for hepatomegaly and splenomegaly.[] The patient was started on aggressive intravenous fluid hydration and intravenous calcitonin, after which her altered mental status resolved and both kidney function and hypercalcemia[]

  • Upper Respiratory Infection

    Participants with contra-indicated medical conditions (hypercalcemia, parathyroid disorder, chronic kidney disease, use of anticonvulsants, malabsorption syndromes, sarcoidosis[] Approximately half of EBV mononucleosis cases involve generalized adenopathy or splenomegaly. An enlarged liver may also be palpable.[]

  • Hypersplenism

    Anemia, thrombocytopenia, hypercalcemia, and splenomegaly indicated progression to acute-type ATL.[] While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[] "Hypercalcemia and huge splenomegaly presenting in an elderly patient with B-cell non-Hodgkin's lymphoma: a case report" .[]

  • Plasma Cell Leukemia

    Patient also had azotemia, hypercalcemia, and hyperuricemia. The patient was started on chemotherapy along with supportive care.[] Primary Plasma cell leukaemia is more characterised by an extra medullar involvement such as hepatomegaly, splenomegaly, lymphadenopathy, lepto-meningeal infiltration or extramedullary[] Compared with multiple myeloma, pPCL presents more often with extramedullary involvement, anemia, thrombocytopenia, hypercalcemia, elevated serum β(2)-microglobulin and lactate[]

  • Familial Mediterranean Fever

    Regarding the presence of back pain, anemia, hypercalcemia, and kidney failure, a diagnosis of MM was suspected.[] Her persistent left elbow effusion resolved and her splenomegaly rapidly disappeared.[] […] expressions, such as of M694V/M694V homozygous, are more likely to have involvement of arthritis, renal amyloidosis, erysipelas-like skin lesions, oral lesions, higher fever, and splenomegaly[]

  • Essential Thrombocythemia

    Other causes of hypercalcemia were excluded.[] And the clinical characteristics of ET patients, such as WBC counts, hemoglobin level, splenomegaly and thrombosis, were influenced by JAK2V617F mutation burden.[] […] essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly[]

  • Paraneoplastic Syndrome

    Among patients with only one PNS, hypertension (p 0.012) and hypercalcemia (p 0.000) were related to advanced stage.[] Additional unusual features included splenomegaly, hyperprolactinaemia and skin changes.[] To elucidate the pathogenesis of this humoral hypercalcemia, BRA and colony-stimulating activity in both the conditioned medium and cells were characterized.[]

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