Hypercalciuria: Causes & Reasons

Possible Causes for Hypercalciuria

Metabolic acidosis, hypercalciuria, hypocitraturia, tubular phosphate reabsorption and growth retardation in the patient improved with alkali therapy. [ncbi.nlm.nih.gov]

Major risk factors for nephrolithiasis include alkaline urine, hypercalciuria and hypocitraturia. [doi.org]

We report a 13-month-old boy with MSK who had features of distal renal tubular acidosis (nephrocalcinosis, hypercalciuria, hypocitraturia) and failed to thrive. [ncbi.nlm.nih.gov]

Bartter Syndrome

In some individuals, hypercalciuria is also present. Mutations in several genes have been associated with the disorder. [journalrip.com]

BARTS1 Bartter syndrome type 1 Bartter syndrome type 1 antenatal hyperprostaglandin E syndrome 1 hypokalemic alkalosis with hypercalciuria 1 antenatal edit English Bartter [wikidata.org]

[…] in active chloride reabsorption in the loop of Henle; characterized by primary juxtaglomerular cell hyperplasia with secondary hyperaldosteronism, hypokalemic alkalosis, hypercalciuria [medical-dictionary.thefreedictionary.com]

Oculocerebrorenal Syndrome

We conclude that hypercalciuria and its sequelae may occur commonly in patients with the Lowe syndrome as a component of tubular dysfunction or a complication of therapy. [ncbi.nlm.nih.gov]

[…] type, including low molecular-weight (LMW) proteinuria, aminoaciduria, bicarbonate wasting and renal tubular acidosis, phosphaturia with hypophosphatemia and renal rickets, hypercalciuria [ncbi.nlm.nih.gov]

Hypercalciuria/Nephrocalcinosis. Hypercalciuria was present in 15 patients. [cjasn.asnjournals.org]

Primary Hyperoxaluria

Type II Hypercalciuria is affected by calcium consumption in the diet. Therefore, calcium restriction leads to decreased risk of stone formation. [health.ucsd.edu]

A high consumption of sodium causes hypercalciuria by reduced proximal tubular re-absorption of calcium. Urinary citrate is reduced. [bestpractice.bmj.com]

[…] accompanied by intermittent hypercalciuria. [nature.com]

Primary Hyperoxaluria Type 3

Introduction Idiopathic hypercalciuria is an important1 and common2 risk factor for the formation of stones, and uncontrolled hypercalciuria is a cause of recurrences.3 Thiazides [nejm.org]

Type II Hypercalciuria is affected by calcium consumption in the diet. Therefore, calcium restriction leads to decreased risk of stone formation. [health.ucsd.edu]

[…] accompanied by intermittent hypercalciuria. [nature.com]

Primary Hyperoxaluria Type 1

Introduction Idiopathic hypercalciuria is an important1 and common2 risk factor for the formation of stones, and uncontrolled hypercalciuria is a cause of recurrences.3 Thiazides [nejm.org]

Type II Hypercalciuria is affected by calcium consumption in the diet. Therefore, calcium restriction leads to decreased risk of stone formation. [health.ucsd.edu]

[…] accompanied by intermittent hypercalciuria. [nature.com]

Primary Hyperoxaluria Type 2

Introduction Idiopathic hypercalciuria is an important1 and common2 risk factor for the formation of stones, and uncontrolled hypercalciuria is a cause of recurrences.3 Thiazides [nejm.org]

Type II Hypercalciuria is affected by calcium consumption in the diet. Therefore, calcium restriction leads to decreased risk of stone formation. [health.ucsd.edu]

[…] accompanied by intermittent hypercalciuria. [nature.com]

Acromegaly

[…] include neurological symptoms (headache, diplopia, bitemporal hemianopsia, carpal tunnel syndrome), osteoarthritis, visceromegalies, cardiomegaly, arterial hypertension, hypercalciuria [scielo.br]

Reports indicate that hypercalciuria and nephrolithiasis may occur in 6–77% of patients with acromegaly. [hindawi.com]

Metabolic features • Impaired glucose tolerance • Diabetes mellitus • Insulin resistance • Other endocrine consequences • Goiter • Hypercalciuria • Galactorrhea • Decrease [slideshare.net]

Autosomal Recessive Hypophosphatemic Rickets Type 2

The other members of the family presented some of these alterations: the mother, hypercalciuria and high 1,25 dihydroxyvitamin D concentrations; the son, hypercalciuria, high [ojrd.biomedcentral.com]

[…] cotransporter: presentation as hypercalciuria and nephrolithiasis. [link.springer.com]

Hypercalcemia, hypercalciuria, and nephrocalcinosis with reduced renal function may complicate treatment. [msdmanuals.com]

Fanconi Renotubular Syndrome Type 2

It is usually characterized by the tubular wasting of nutrients and salts (GLUCOSE; AMINO ACIDS; PHOSPHATES; and BICARBONATES) resulting in HYPOKALEMIA; ACIDOSIS; HYPERCALCIURIA [connects.catalyst.harvard.edu]

Hypercalciuria Along with other proximal tubular damage renal calcium wastage is observed. Systematic References: 1. [moldiag.com]

liver disease and sickle cell disease. c) Often presents with NAG metabolic acidosis, hypokalemia, hypercalciuria and an elevated urine pH (greater than 5.5). 5) Type 2 [morningreporttgh.blogspot.com]

Wilson Disease

Other features Renal: A renal Fanconi's syndrome may occur with hypercalciuria and nephrocalcinosis along with renal loss of amino acids, glucose, phosphate and excess uric [patient.info]

Other systems may also be affected by circulating copper - renal (hypercalciuria, nephrolithiasis), cardiac (rhythm abnormalities and myopathy), endocrine (hypoparathyroidism [symptoma.com]

Familial Hyperaldosteronism Type 3

This results in symptomatic diuresis from salt wasting with resulting hypokalemia, hypovolemia, hypercalciuria, and metabolic acidosis (McCance et al., 2010). [wikilectures.eu]

[…] excess syndrome (AME) Genetic or acquired defect of 11-HSD gene Cortisone decreases and cortisol accumulates and binds to aldosterone receptors Severe juvenile hypertension Hypercalciuria [wikidoc.org]

[…] hyperparathyroidism with multiple ossifying jaw fibromas - See Hyperparathyroidism-jaw tumor syndrome Familial primary hypomagnesemia Familial primary hypomagnesemia with hypercalciuria [rarediseases.info.nih.gov]

Nephrolithiasis

HHRH may be an underdiagnosed condition that can masquerade as idiopathic hypercalciuria or osteopenia. [ncbi.nlm.nih.gov]

[…] gastrointestinal calcium absorption and hypercalciuria. [ncbi.nlm.nih.gov]

Using a proteomic approach, we aimed to identify and compare the urinary excretion of proteins involved in lipid transport and metabolism in children with kidney stones and hypercalciuria [ncbi.nlm.nih.gov]

Urolithiasis

Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. [ajkd.org]

Metabolic investigation for a renal stone revealed that she had hypercalcemia, hypophosphatemia, and hypercalciuria. [ncbi.nlm.nih.gov]

In a substantial number of patients, however, hypercalciuria without an identifiable cause (idiopathic hypercalciuria) is the most common cause of increased calcium excretion [symptoma.com]

Urate Kidney Stone

[…] calcium to enter the urine) can cause hypercalciuria. [ugwne.com]

[…] defect that causes excessive calcium to enter the urine) can all cause hypercalciuria. [healthcommunities.com]

The ensuing hypophosphatemia stimulates calcitriol synthesis, resulting in hypercalciuria. [aacc.org]

Transient Sarcoidosis

Hypercalcaemia and hypercalciuria result primarily from the synthesis of 1,25 hydroxyvitamin-D 3 in sarcoid granulomas. [academic.oup.com]

[…] addition to organ-involvment consultations, needs cardiac and opthalmologic w/u Lab serum calcium 10% of patients with sarcoidosis will have at least transient hypercalcemia; hypercalciuria [medicine.uiowa.edu]

In a small percentage of patients there may be a transient hypercalcemia and hypercalciuria in the early stages of the disease. [medical-dictionary.thefreedictionary.com]

Hypercalcemic Nephropathy

Abstract To understand the mechanisms responsible for the persistent hypercalciuria and reduced glomerular filtration rate (GFR) previously found in 6 of 10 patients surgically [ncbi.nlm.nih.gov]

Reyes Renal hypomagnesemia, hypercalciuria and nephrocalcinosis in a middle-aged man [35.] T. Tajima, J. Nakae, K. [analesdepediatria.org]

These include renal colic, polyuria and polydipsia: Renal colic is usually caused by pre-existing nephrolithiasis, as may occur in patients with chronic hypercalciuria. [en.wikipedia.org]

Hypercalcemia

KEYWORDS: Genetics; Hypercalciuria; Osteoporosis; Urolithiasis; Vitamin D [ncbi.nlm.nih.gov]

Calcium metabolism disturbances occur in up to 20% of patients, of which hypercalciuria and asymptomatic hypercalcemia are most common. [ncbi.nlm.nih.gov]

He showed hypercalcemia > 3mmol/l and acute, hypovolemic renal failure with profound nephrocalcinosis, but no hypercalciuria. [ncbi.nlm.nih.gov]

Nephrocalcinosis

He was well grown up, normotensive, but had moderate renal failure (CKD 3 stage), mild hypomagnesaemia and severe hypercalciuria and nephrocalcinosis. [ncbi.nlm.nih.gov]

Abstract Familial Hypomagnesemia, Hypercalciuria with Nephrocalcinosis is a rare autosomal recessive inherited disease associated with renal failure. [ncbi.nlm.nih.gov]

BACKGROUND: Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis is a rare tubulopathy leading to renal calcification and progressive renal failure. [ncbi.nlm.nih.gov]

Idiopathic Hypercalciuria

Who gets Idiopathic Hypercalciuria? [dovemed.com]

What is idiopathic hypercalciuria? Idiopathic hypercalciuria is the excessive excretion of calcium in the urine without obvious cause. [patientslikeme.com]

Abstract: Idiopathic Hypercalciuria (IH), a heterogenous disorder, is the most common cause of urolithiasis in children. [eurekaselect.com]

Idiopathic Hypercalcemia

Adult carriers of homozygous mutation may be asymptomatic but all had hypercalciuria and nephrocalcinosis. [doi.org]

Continuous high oral and parenteral fluid intake resulted in a moderate decrease of hypercalcaemia and no change in hypercalciuria. [endocrine-abstracts.org]

Hypercalciuria, in that particular context, is the result of increased intestinal calcium absorption, due to overproduction of calcitriol. [bmj.com]

Familial Hypocalciuric Hypercalcemia Type 3

Gain-of-function CaSR mutations have been shown to result in autosomal dominant hypocalcaemia with hypercalciuria (ADHH) and Bartter's syndrome type V. [slideplayer.com]

[…] with this condition leads it to being referred to as autosomal-dominant hypocalcemia with hypercalciuria (ADHH). [ijem.in]

Article Language French Keyword (fr) HYPERCALCEMIE HYPERCALCIURIE HEREDITAIRE HOMME METABOLISME PATHOLOGIE ELEMENT MINERAL MALADIES METABOLIQUES Keyword (en) HYPERCALCEMIA HYPERCALCIURIA [pascal-francis.inist.fr]

Familial Hypocalciuric Hypercalcemia Type 2

[…] with this condition leads it to being referred to as autosomal-dominant hypocalcemia with hypercalciuria (ADHH). [ijem.in]

Gain-of-function CaSR mutations have been shown to result in autosomal dominant hypocalcaemia with hypercalciuria (ADHH) and Bartter's syndrome type V. [slideplayer.com]

Hypercalciuria with nephrolithiasis is common. [merckmanuals.com]

Staghorn Calculus

Hyperuricemia, cystinuria and hypercalciuria were found in 14.6%, 2.4% and 37.8%, respectively. Hypercalciuria was found more frequently in calcium-stone cases. [onlinelibrary.wiley.com]

Metabolic abnormalities were found in 68.2% of patients with hypercalciuria (64.2%) and hypocitraturia (53.3%) being the most common disorders. [ncbi.nlm.nih.gov]

other results similar to excess dietary meat Primary hyperparathyroidism Creates persistent hypercalciuria Prolonged immobilization Bone turnover creates hypercalciuria [aafp.org]

Acute Sarcoidosis

[…] patients) ↑ Angiotensin-converting enzyme (ACE) blood levels; may be used to monitor disease activity and therapy ↑ Inflammatory markers, possible lymphopenia Urine analysis: hypercalciuria [amboss.com]

Hepatomegaly - Occurs in 25% of cases, with elevation in liver function tests [LFTs]; usually not clinically significant Nephrolithiasis - May be caused by hypercalcemia and hypercalciuria [emedicine.medscape.com]

"Pregnancy and sarcoidosis: an insight into the pathogenesis of hypercalciuria". Chest. 126 (3): 995–8. doi:10.1378/chest.126.3.995. PMID 15364785. [en.wikipedia.org]

Renal Tubular Dysfunction

Investigations revealed normal renal function, hypercalciuria, reduced tubular reabsorption of phosphorus, hypomagnesemia and renal magnesium wasting. [ncbi.nlm.nih.gov]

Renal tubular dysfunction with hypercalciuria and hypocalcemia in the absence of pre-existing renal disease or concurrent medications has not been described at presentation [ncbi.nlm.nih.gov]

Regarding management, this patient was put on hydrochlorothiazide for hypercalciuria and advised regular follow-up. [sjkdt.org]

Renal Tubular Acidosis

Major risk factors for nephrolithiasis include alkaline urine, hypercalciuria and hypocitraturia. [doi.org]

Hypercalciuria can often lead to nephrocalcinosis or nephrolithiasis. [lecturio.com]

In these latter cases hypercalciuria is present in complete and incomplete type I renal tubular acidosis. [doi.org]

Proximal Renal Tubular Acidosis

After treatment, metabolic acidosis and hypercalciuria improved, and the patient had a catch-up growth phase. [ncbi.nlm.nih.gov]

No hypercalciuria was detected, and no evidence of rickets or osteomalacia was found by x-ray studies. [ncbi.nlm.nih.gov]

[…] formation with hypercalciuria but normal blood calcium. [patient.info]

Renal Sarcoidosis

Sarcoidosis is a systemic granulomatous disease of unknown etiology and is associated with a wide variety of renal disorders including nephrolithiasis, hypercalciuria, hypercalcemia [ncbi.nlm.nih.gov]

When it affects the kidneys, the most prevalent manifestations are hypercalcemia and hypercalciuria. [scielo.br]

Hypercalcaemia (2%-10%) and hypercalciuria (6%-30%) can cause nephrocalcinosis, lithiasis and renal insufficiency. [revistanefrologia.com]

Gitelman Syndrome

Hypercalciuria in potassium-losing nephropathy: a variant of Bartter's syndrome. Aust. Paediat J. 10, 286–295 (1974). 20 Matsumoto, J. et al. [doi.org]

[7] Bartter's syndrome or Gitelman's syndrome can be differentiated by: Hypokalaemic alkalosis with hypercalciuria (true Bartter's syndrome). [patient.info]

Those who survive infancy develop hypokalemia, metabolic alkalosis, polyuria, and hypercalciuria. [intechopen.com]