Hypercellular Bone Marrow: Causes & Reasons

Possible Causes for Hypercellular Bone Marrow

bone marrow with panmyelosis Erythroid hyperplasia often predominates Low serum erythropoietin (EPO) Endogenous erythroid colony formation in vitro Variable excess platelet [surgpathcriteria.stanford.edu]

Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV. [ncbi.nlm.nih.gov]

Myeloproliferative Disease

The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more [clinlabnavigator.com]

marrow hypercellularity. [youtube.com]

Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain. [emedicine.com]

Primary Hypereosinophilic Syndrome

No cytogenetic study or bone marrow biopsy was made. [htct.com.br]

marrow Normocellular or hypercellular marrow with an increase in eosinophils and eosinophilic precursors with orderly maturation Bone marrow eosinophilia proposed criteria [pathologyoutlines.com]

Another myelogram showed hypercellular bone marrow with 78% of cells being granulocytes (27% eosinophils and 51% eosinophil precursors) of hypoblastic erythroid lineage and [htct.com.br]

Paroxysmal Nocturnal Hemoglobinuria

Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular. [emedicine.medscape.com]

The degree of marrow failure may vary from severe aplastic anemia to a decrease in the number of hematopoietic stem cells. [emedicine.medscape.com]

Bone marrow failure is possibly due to similar destruction by complement, but the cause or causes are still poorly understood. [emedicine.medscape.com]

Secondary Polycythemia

The renal biopsy revealed membranous nephropathy, and the bone marrow biopsy disclosed hypercellular marrow with mild panhyperplasia. [ncbi.nlm.nih.gov]

Bone marrow is hypercellular with prominent megakaryocytes. Serum erythropoietin level is usually low. Blood viscosity is increased. [labpedia.net]

Bone marrow normal increased erythropoiesis hypercellular increased erythropoiesis and leucopoiesis 6. leucocyte alkaline phosphatase score normal normal increased in 70% [labpedia.net]

Acquired Spherocytosis

Bone marrow biopsy was hypercellular with a decreased M:E ratio and dysplastic erythroid precursors. [bloodjournal.org]

Chronic Phase of Chronic Myeloid Leukemia

marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic [pathologyoutlines.com]

A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities. [hematologyandoncology.net]

marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal [emedicine.medscape.com]

Acute Leukemia

ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B [pathologyoutlines.com]

Bone marrow aspirate examination revealed hypercellularity with 70% blast cells. [ncbi.nlm.nih.gov]

Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 × 104/μL) and 89.0% of blast-like cells of all nucleated cells. [ncbi.nlm.nih.gov]

Chronic Myeloid Leukemia

Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow. [lecturio.com]

marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors. [doi.org]

Pernicious Anemia

Figure 1: Bone marrow aspiration test at admission. (A) (×40) Hypercellular marrow. [academic.oup.com]

Bone marrow aspirate one day after admission. (a) Erythroid and megakaryocyte hyperplasia: The bone marrow is hypercellular with ineffective erythropoiesis. [tandfonline.com]

marrow aspirate smear revealed hypercellularity, with hyperplasia and immaturity of erythroid lineage, megaloblastosis, giant metamyelocytes and hypersegmented neutrophils [scielo.br]

Leukemia

Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed [ncbi.nlm.nih.gov]

Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells. [web.archive.org]

Marrow with too many blood-forming cells is said to be hypercellular. If too few of these cells are found, the marrow is called hypocellular. [web.archive.org]

Autoimmune Hemolytic Anemia

Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma. [dx.doi.org]

Hereditary Spherocytosis

Hereditary spherocytosis and hereditary elliptocytosis are congenital red blood cell (RBC) membrane disorders that can cause a mild hemolytic anemia. Symptoms, generally milder in hereditary elliptocytosis, include variable degrees of anemia, jaundice, and splenomegaly. Diagnosis requires demonstration of increased RBC[…] [merckmanuals.com]

Refractory Anemia with Excess Blasts in Transformation

Cytopenia of at least one lineage in the peripheral blood (usually anemia) Normal or hypercellular bone marrow with dysplastic changes Less than 1 percent blasts in the peripheral [medicalcriteria.com]

marrow Hypercellular bone marrow with dysplasia at least in granulocyte lineage No Ph chromosome, BCR-ABL1 fusion gene or rearrangement of PDGFRA or PDGFRB Diagnosis of atypical [slideshare.net]

Clinics RAEB usually presents with hypercellular bone marrow (BM) with 5-20% blasts (5-9% in RAEB-1 and 10-19% in RAEB-2) and cytopenias of various degree. [atlasgeneticsoncology.org]

Chronic Infection

Bone marrow aspirate and biopsy results indicated hypercellular marrow with a reactive inflammatory response and hemophagocytosis. [academic.oup.com]

Ayerza Syndrome

Ayerza syndrome is named after Abel Ayerza and encompasses the clinical features of pulmonary hypertension. It is a progressive disease with mixed etiology, characterized by increased resistance in the pulmonary blood vessels. Ayerza syndrome (AS) describes the signs of pulmonary (arterial) hypertension. It is[…] [symptoma.com]

Beta Thalassaemia Major

Funding Profiles Access available for Technion staff. Please sign in to see the Agency profiles (upper left corner) The Cooley’s Anemia Foundation is dedicated to serving people afflicted with various forms of thalassemia, most notably the major form of this genetic blood disease, Cooley’s anemia/thalassemia major.[…] [trdf.co.il]

Chronic Neutrophilic Leukemia

bone marrow with predominant neutrophilic granulopoiesis (M:E is 20:1 or more), the number of myeloblasts and promyelocytes is not increased, myelocytes and mature neutrophils [atlases.muni.cz]

These cases are characterized by a high number of mature neutrophils in peripheral blood (PB), a hypercellular bone marrow due to neutrophilic granulocyte proliferation and [learningcenter.ehaweb.org]

marrow Hypercellular bone marrow biopsy with increased neutrophils showing no overt dysplasia, normal megakaryocytes Hepatosplenomegaly No reactive cause for neutrophilia [clinicaladvisor.com]

Fetal Erythroblastosis

Background A French midwife was the first to report hemolytic disease of the newborn (HDN) in a set of twins in 1609. In 1932, Diamond and colleagues described the relationship among fetal hydrops, jaundice, anemia, and erythroblasts in the circulation, a condition later called erythroblastosis fetalis. Levine later[…] [emedicine.medscape.com]

Sickle Cell Anemia

Sickle cell disease (sickle cell anemia, drepanocytosis) is an autosomal recessive blood disorder, characterized by sickle-shaped erythrocytes. Chronic anemia is present in all individuals with sickle cell disease. It is generally asymptomatic, though patients report chronic fatigue and exercise intolerance.[…] [symptoma.com]

Idiopathic Refractory Anemia

[…] of the bone marrow. [amboss.com]

Clinics RA usually presents with hypercellular bone marrow (BM) and anemia. [atlasgeneticsoncology.org]

Congenital Hemolytic Anemia

Am J Hematol. 2015 Mar;90(3):187-92. doi: 10.1002/ajh.23888. Epub 2014 Nov 24. Rice HE 1, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta[…] [ncbi.nlm.nih.gov]

Cyanotic Congenital Heart Disease

We treated two patients with congenital cyanotic heart disease (CCDH) in whom associated hypertrophic osteoarthropathy (HOA) developed. Both were severely cyanotic and hypoxic for many years before HOA was fully manifested. Clinical and roentgenographic indications of bone and joint lesions disappeared completely[…] [ncbi.nlm.nih.gov]

Microangiopathic Hemolytic Anemia

Microangiopathic hemolytic anemia was found in 7 of 20 patients with systemic scleroderma, an indication that this complication is not uncommon. Since only 4 had severe hypertension, pressures in the 'malignant' range seem not to be necessary for the development of the anemia. All 7 patients had renal arterial fibrin[…] [jhu.pure.elsevier.com]

Refractory Anemia

B (Case 5), Many large and hyperchromatic megakaryocytes are clustered in a hypercellular bone marrow (H&E, ×200). [academic.oup.com]

[…] should be classified as RAEB-1 Microscopic (histologic) images Images hosted on PathOut server: Bone marrow biopsy: Slightly hypercellular for a 53 year old man, marked erythroid [pathologyoutlines.com]

A bone marrow aspirate and biopsy revealed a hypercellular bone marrow (30-50%) with prominent erythroid precursor cells. [omicsonline.org]

Refractory Anemia with Excess Blasts

The hematological profile in man is one of peripheral cytopenia in one or all of the marrow cell lines which occurs despite a normal to hypercellular bone marrow. [ncbi.nlm.nih.gov]

Clinics RAEB usually presents with hypercellular bone marrow (BM) with 5-20% blasts (5-9% in RAEB-1 and 10-19% in RAEB-2) and cytopenias of various degree. [atlasgeneticsoncology.org]

Bone marrow core biopsy The bone marrow is usually hypercellular. Dysplastic megakaryocytes are frequently seen. [imagebank.hematology.org]

Pyruvate Kinase Deficiency

Embden-Meyerhof pathway Erythrocytes (mature red blood cells) completely depend on glucose as a source of energy. Glucose is usually catabolized to pyruvate and lactate in the Embden-Meyerhof pathway, which is the major anaerobic glycolytic pathway. In the process, adenosine triphosphate (ATP), which is essential[…] [emedicine.medscape.com]

Altitude Sickness

Take a deep breath and read how you can survive altitude sickness. Emergency Situation : You’re hiking in Grand Teton National Park, admiring the incredible vistas and enjoying the crisp mountain air. After several hours, you develop a pounding headache, feel breathless, and experience lightheadedness and dizziness.[…] [scoutingmagazine.org]

Acute Panmyelosis with Myelofibrosis

marrow aspirate was unsuccessful but bone marrow biopsy ( Figure 2 ) revealed hypercellular bone marrow with panmyeloid proliferation. [ncbi.nlm.nih.gov]

Bone marrow biopsy showed a hypercellular marrow in 10/12 patients with a significant infiltration of pathological blasts (range: 30 - 60%). [ncbi.nlm.nih.gov]

The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow. [lecturio.com]

Atypical Chronic Myeloid Leukemia

bone marrow with granulocytic proliferation and dysplasia, bone marrow blast less than 20% and absence of BCR/ABL fusion gene. [ncbi.nlm.nih.gov]

bone marrow biopsy with granulocytic proliferation and granulocytic dysplasia, with or without dysplasia of the erythroid and megakaryocytic lineages • Neutrophil precursors [caprockhematology.com]

marrow : hypercellular marrow with increased M/E ratio, marked granulocytic hyperplasia and dysplasia (convoluted lobulation of nuclei, pseudo-Pelger-Huët forms), < 20% blasts [pathologyoutlines.com]