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172 Possible Causes for Hypercellular Bone Marrow, Hypersplenism

  • Leukemia

    Anemia and thrombocytopenia may be present in one third of cases, which may result from bone marrow failure due to lymphoid infiltration and/or hypersplenism.[] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[] Extremely severe hemolytic anemia may occur, associated with secondary hypersplenism, lymphoid splenic infiltration or anemia as a result of disseminated intravascular coagulation[]

  • Myeloproliferative Disease

    As peripheral blood count abnormalities may sometimes be masked by hypersplenism, other secondary radiologic findings may be the only clue to an occult myeloproliferative[] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[]

  • Autoimmune Hemolytic Anemia

    Spherocytosis Paroxysmal Nocturnal Hemogloburia b) Extrinsic Causes Autoimmune Hemolytic Anemia Infections – Malaria, Babesiosis Microangiopathic Hemolytic Anemias – DIC, TTP-HUS Hypersplenism[] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[] Although a DAT was not reported, the author argued that the hemolysis was autoimmune because malaria and hypersplenism were excluded, and the anemia resolved with methotrexate[]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[] marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors.[]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[]

  • Infectious Mononucleosis

    One year later he underwent splenectomy for hypersplenism; at surgery, mesenteric lymphadenopathy and chylous ascites were noted.[] A bone marrow aspirate ruled out haemophagocytic syndrome.[] Urinalysis showed hypercellularity, with extensive tubular epithelial cells, granular casts and amorphous material.[]

  • Primary Myelofibrosis

    Anaemia (may occur due to ineffective erythropoiesis, erythroid hypoplasia and hypersplenism) may cause fatigue, weakness and dyspnoea.[] A biopsy of the lytic lesion was done, revealing hypercellular bone marrow with hyperplastic granulopoiesis associated with megakaryocytic proliferation and atypia, accompanied[] Anemia may occur as a result of ineffective erythropoiesis, erythroid hypoplasia, and hypersplenism.[]

  • Pancytopenia

    In the absence of increased peripheral destruction, for example, hypersplenism, bone marrow (BM) failure should be considered as the cause of pancytopenia.[] Key words: Pancytopenia, Pallor, Hypercellular Bone Marrow, Megaloblastic Anaemia, Malaria Advertisement Oxidants and Antioxidants in Medical Science SUBMIT YOUR ARTICLE NOW[] Hypersplenism secondary to portal hypertension (cirrhosis) was the second most common diagnosis (n 19).[]

  • Acquired Spherocytosis

    […] destruction Immune thrombocytopenia *Idiopathic thrombocytopenic purpura (ITP) *Neonatal alloimmune thrombocytopenia (NAITP) Disseminated intravascular coagulation (DIC) Hypersplenism[] Bone marrow biopsy was hypercellular with a decreased M:E ratio and dysplastic erythroid precursors.[] […] anaemia (found in patients with disseminated intravascular coagulation or haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura ), infection (malaria, sepsis), hypersplenism[]

  • Paroxysmal Nocturnal Hemoglobinuria

    PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[] […] rate in the SHEPHERD study could reflect inclusion of patients with lower platelet counts that may be due to defective hematopoiesis or platelet consumption as a result of hypersplenism[]

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