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172 Possible Causes for Hypercellular Bone Marrow, Hypersplenism

  • Leukemia

    Anemia and thrombocytopenia may be present in one third of cases, which may result from bone marrow failure due to lymphoid infiltration and/or hypersplenism.[web.archive.org] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Extremely severe hemolytic anemia may occur, associated with secondary hypersplenism, lymphoid splenic infiltration or anemia as a result of disseminated intravascular coagulation[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    As peripheral blood count abnormalities may sometimes be masked by hypersplenism, other secondary radiologic findings may be the only clue to an occult myeloproliferative[radiopaedia.org] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[emedicine.com]

  • Autoimmune Hemolytic Anemia

    Spherocytosis Paroxysmal Nocturnal Hemogloburia b) Extrinsic Causes Autoimmune Hemolytic Anemia Infections – Malaria, Babesiosis Microangiopathic Hemolytic Anemias – DIC, TTP-HUS Hypersplenism[errolozdalga.com] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[dx.doi.org] Although a DAT was not reported, the author argued that the hemolysis was autoimmune because malaria and hypersplenism were excluded, and the anemia resolved with methotrexate[casesjournal.biomedcentral.com]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[lecturio.com] marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors.[doi.org]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Infectious Mononucleosis

    One year later he underwent splenectomy for hypersplenism; at surgery, mesenteric lymphadenopathy and chylous ascites were noted.[dx.doi.org] A bone marrow aspirate ruled out haemophagocytic syndrome.[ncbi.nlm.nih.gov] Urinalysis showed hypercellularity, with extensive tubular epithelial cells, granular casts and amorphous material.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Anaemia (may occur due to ineffective erythropoiesis, erythroid hypoplasia and hypersplenism) may cause fatigue, weakness and dyspnoea.[patient.info] A biopsy of the lytic lesion was done, revealing hypercellular bone marrow with hyperplastic granulopoiesis associated with megakaryocytic proliferation and atypia, accompanied[ncbi.nlm.nih.gov] Anemia may occur as a result of ineffective erythropoiesis, erythroid hypoplasia, and hypersplenism.[emedicine.medscape.com]

  • Pancytopenia

    In the absence of increased peripheral destruction, for example, hypersplenism, bone marrow (BM) failure should be considered as the cause of pancytopenia.[ncbi.nlm.nih.gov] Key words: Pancytopenia, Pallor, Hypercellular Bone Marrow, Megaloblastic Anaemia, Malaria Advertisement Oxidants and Antioxidants in Medical Science SUBMIT YOUR ARTICLE NOW[scopemed.org] Hypersplenism secondary to portal hypertension (cirrhosis) was the second most common diagnosis (n 19).[ayubmed.edu.pk]

  • Acquired Spherocytosis

    […] destruction Immune thrombocytopenia *Idiopathic thrombocytopenic purpura (ITP) *Neonatal alloimmune thrombocytopenia (NAITP) Disseminated intravascular coagulation (DIC) Hypersplenism[slideshare.net] Bone marrow biopsy was hypercellular with a decreased M:E ratio and dysplastic erythroid precursors.[bloodjournal.org] […] anaemia (found in patients with disseminated intravascular coagulation or haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura ), infection (malaria, sepsis), hypersplenism[patient.info]

  • Paroxysmal Nocturnal Hemoglobinuria

    PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[bloodjournal.org] […] rate in the SHEPHERD study could reflect inclusion of patients with lower platelet counts that may be due to defective hematopoiesis or platelet consumption as a result of hypersplenism[bloodjournal.hematologylibrary.org]

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