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115 Possible Causes for Hypercellular Bone Marrow, Hyperuricemia

  • Chronic Myeloid Leukemia

    Because of the increased turnover of myeloid cells, hyperuricemia may be present, and for this reason allopurinol is also indicated.[clinicaladvisor.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] The rapid killing of leukemic cells releases the intracellular contents into the blood circulation which causes hyperuricemia, hyperkalemia, hyperphosphatemia and may lead[lecturio.com]

  • Polycythemia Vera

    The maximum-tolerated dose of gandotinib was 120mg daily, based on dose-limiting toxicities of blood creatinine increase or hyperuricemia at higher doses.[ncbi.nlm.nih.gov] bone marrow 5.[slideshare.net] Splenomegaly is relatively common, seen in approximately two-thirds of patients. 4 Hyperuricemia (from increased cell turnover) and gout are also associated with polycythemia[mdedge.com]

  • Acute Leukemia

    Other laboratory findings may include hyperuricemia, hyperphosphatemia, hyperkalemia or hypokalemia, hypocalcemia, elevated serum hepatic transaminases or LDH, hypoglycemia[merckmanuals.com] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] In advanced cases, patients may even present with altered mental status and renal failure (due to hyperuricemia).[symptoma.com]

  • Myeloproliferative Disease

    […] leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to gouty arthritis that is secondary to hyperuricemia[emedicine.medscape.com] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] […] neoplasms include the following: Easy fatigability Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to gouty arthritis secondary to hyperuricemia[emedicine.medscape.com]

  • Leukemia

    Other laboratory findings may include hyperuricemia, hyperphosphatemia, hyperkalemia or hypokalemia, hypocalcemia, elevated serum hepatic transaminases or LDH, hypoglycemia[merckmanuals.com] […] factors) Special considerations apply to the treatment of the following: Burkitt leukemia Ph ALL ALL in older children and younger adults Relapsed ALL ALL in patients with hyperuricemia[emedicine.medscape.com] Hydration (twice the daily maintenance volume), urine alkalinization (pH 7 to 8), and electrolyte monitoring can prevent the hyperuricemia, hyperphosphatemia, hypocalcemia[merckmanuals.com]

  • Acute Undifferentiated Leukemia

    Comprehensive metabolic panel: This may reveal electrolyte derangements and other abnormal parameters, such as hyperuricemia, hypocalcemia, hyper- or hypokalemia, hypoglycemia[symptoma.com] 7 Year Member Joined: Feb 16, 2008 Messages: 47 Likes Received: 0 This was from a practice teaching case and I'm not sure I agree...Hypercellular bone marrow with 94% blasts[forums.studentdoctor.net]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Acute Lymphoblastic Leukemia

    It causes hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia and may lead to fatal acute renal injury .[lecturio.com] Patients with a high tumor burden, particularly those with severe hyperuricemia, can present in renal failure.[emedicine.medscape.com] […] factors) Special considerations apply to the treatment of the following: Burkitt leukemia Ph ALL ALL in older children and younger adults Relapsed ALL ALL in patients with hyperuricemia[emedicine.medscape.com]

  • Alkylating Agent

    […] to electron rich nucleophilic sites on biologic molecules; preferred binding site of alkylation is N-7 position of guanine; toxicites: myelosuppresion (neutropenia), N/V, hyperuricemia[quizlet.com] marrow: hypercellular, normocellular or hypocellular marrow Often severely dysplastic changes in blood and marrow affecting two or more lineages Myelofibrosis (15% cases)[pathologyoutlines.com] […] progression Microscopic (histologic) description Peripheral blood: one or more cytopenias, anemia with macrocytosis and poikoilocytosis, dysplastic changes in neutrophils Bone[pathologyoutlines.com]

  • Cyanotic Congenital Heart Disease

    Hyperuricemia is common, acute gouty arthritis is less common than uric acid levels would predict, and overt tophaceous deposits of uric acid are exceptional.[ncbi.nlm.nih.gov] Other attendant problems are hyperuricemia, gout and uric acid nephropathy .[omicsonline.org] Other problems associated with polycythemia are hyperuricemia, gout and uric acid nephropathy and therefore, serum uric level should be monitored in adults with cyanotic CHD[omicsonline.org]

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