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137 Possible Causes for Hypercellular Bone Marrow, Lactate Dehydrogenase Increased

  • Chronic Myeloid Leukemia

    […] numbers of eosinophils and basophils Differential WCC shows granulocytes at all stages of development Anaemia (normocytic/normochromic) Biochemistry: Lactate dehydrogenase[geekymedics.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[lecturio.com]

  • Acute Lymphoblastic Leukemia

    Serum level of lactate dehydrogenase (LDH) predicts increased anaerobic glycolysis and is associated with metabolic modulation in cancer cells.[ncbi.nlm.nih.gov] The leukemic cells of the hypercellular bone marrow then spill into the blood circulation and are visible on routine CBCs .[lecturio.com] The bone marrow was hypercellular, with 64% blasts, which were large in size and showed low nucleus: cytoplasm ratio, monocytoid features, and blue-gray cytoplasm; 80% of[casesjournal.biomedcentral.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[ncbi.nlm.nih.gov] Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] After approximately 2 years, apart from normalization of the lactate dehydrogenase (LDH) level, there was an increase in glycosylphosphatidylinositol (GPI) negative red cells[nejm.org]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[ncbi.nlm.nih.gov] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[ncbi.nlm.nih.gov]

  • Cold Agglutinin Disease

    LDH (lactate dehydrogenase) Increased DAT (direct anti-globulin test) for anti-C3d (antibody to complement protein C3d) Present Haptoglobin Decreased Cold agglutinin titers[cancertherapyadvisor.com] Figure 2 Bone marrow biopsy. A. Low magnification (10 x) view of a slightly hypercellular bone marrow with groups (circled) and scattered large lymphoma cells. B.[ispub.com] Levels of interleukin (IL)-1beta, IL-6, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha increased as did C1-INH, C3, C4, CRP, and lactate dehydrogenase.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[clinicaladvisor.com] Other biochemical changes of hemolysis also are also present, including: increased lactate dehydrogenase (LDH) increased unconjugated bilirubin decreased serum haptoglobin[steadyhealth.com] Lactate dehydrogenase Levels are increased Total and unconjugated bilirubin Levels are increased Bone marrow Aspiration Examination It shows hyperplasia of the erythroid cells[medcaretips.com]

  • Pneumocystis Carinii Pneumonia

    Differential responses to the sequential treatments for PCP and IVL implied that increased serum lactate dehydrogenase (LDH) was due to PCP, whereas hypoxemia and dementia[ncbi.nlm.nih.gov] Bone marrow aspiration and a biopsy specimen showed a hypercellular bone marrow with decreased megakaryopoiesis and reduced erythropoiesis together with an infiltration of[pmj.bmj.com] Serum lactate dehydrogenase levels are commonly increased. CD4 cell count is usually less than 200/µL in HIV-positive individuals.[quizlet.com]

  • Microangiopathic Hemolytic Anemia

    Laboratory abnormalities Anemia Increased lactate dehydrogenase. Increased indirect bilirubin. Decreased haptoglobin. Increased urine urobilinogen.[clinicaladvisor.com] Characteristic laboratory data are a negative direct antiglobulin (Coombs) test, an increased lactate dehydrogenase (LDH) level, increased indirect bilirubin, and low haptoglobin[springerplus.springeropen.com] Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info]

  • Autoimmune Hemolytic Anemia

    Unconjugated bilirubin is usually, but not always, elevated and urine urobilinogen is increased. Lactate dehydrogenase is usually elevated into the thousands.[clinlabnavigator.com] Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info]

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