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39 Possible Causes for Hypercellular Bone Marrow, Lysozyme Increased

  • Leukemia

    Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org] Marrow with too many blood-forming cells is said to be hypercellular. If too few of these cells are found, the marrow is called hypocellular.[web.archive.org]

  • Myeloproliferative Disease

    The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[emedicine.com] This is in contrast to the myelodysplastic syndromes, in which the bone marrow is hypercellular, but the production is ineffective in one or more cell lines, resulting in[clinlabnavigator.com]

  • Acute Leukemia

    Serum and urine levels of muramidase (lysozyme) are usually elevated because of the monocytic proliferation.[intechopen.com] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Polycythemia Vera

    bone marrow 5.[slideshare.net] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[ncbi.nlm.nih.gov] Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic and megakaryocytic proliferation with[pathologyoutlines.com]

  • Primary Myelofibrosis

    A biopsy of the lytic lesion was done, revealing hypercellular bone marrow with hyperplastic granulopoiesis associated with megakaryocytic proliferation and atypia, accompanied[ncbi.nlm.nih.gov] There is a stepwise evolution from an initial pre/fibrotic early stage, characterized by hypercellular bone marrow with absent or minimal reticulin fibrosis, to an overt fibrotic[seer.cancer.gov] Bone marrow aspiration revealed marked megakaryocyte proliferation with atypia of naked nuclei and marrow hypercellularity (90% cellularity).[ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    marrow biopsy and aspirate may show a hypercellular bone marrow with a megaloblastic maturation of cells, which morphologically resembles changes of vitamin B12 deficiency[pathologyoutlines.com] Bone marrow aspirate and biopsy: Marrow is hypercellular with characteristic features of megaloblastic erythropoiesis and presence of large metamyelocytes.[clinicaladvisor.com] Important to rule out cobalamin (Vitamin B12) deficiency because folate treatment will not improve neurologic abnormalities due to cobalamin deficiency Cytology description Bone[pathologyoutlines.com]

  • Acute Myelocytic Leukemia

    Diagnosis Aides: High serum lysozyme (3x normal) A peripheral monocytosis of 5x 10 /L in an otherwise M2 marrow and increased lysozyme A peripheral monocytosis of 5 x 10 [med-ed.virginia.edu] The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow.[lecturio.com] marrow biopsy: Markedly hypercellular marrow with heterogeneous cells, including immature monocytes (irregular nuclei and prominent nucleoli) and neutrophils Stains: Chloroacetate[pathologyoutlines.com]

  • Acute Monocytic Leukemia

    Serum and urinary lysozyme levels were increased.[academic.oup.com] The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow.[lecturio.com] Diagnosis Aides: High serum lysozyme (3x normal) A peripheral monocytosis of 5x 10 /L in an otherwise M2 marrow and increased lysozyme A peripheral monocytosis of 5 x 10 [med-ed.virginia.edu]

  • Secondary Polycythemia

    Basophilia occurs in about two-thirds of patients with uncontrolled disease.130 Serum lysozyme levels are slightly increased in some patients,131 and because of the increased[medtextfree.wordpress.com] The renal biopsy revealed membranous nephropathy, and the bone marrow biopsy disclosed hypercellular marrow with mild panhyperplasia.[ncbi.nlm.nih.gov] Bone marrow is hypercellular with prominent megakaryocytes. Serum erythropoietin level is usually low. Blood viscosity is increased.[labpedia.net]

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