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117 Possible Causes for Hypercellular Bone Marrow, Massive Splenomegaly

  • Chronic Myeloid Leukemia

    Here, we report a case of aCMLin a 5-month baby who presented with massive splenomegaly. The diagnosis was in accordance with the WHO criteria established in 2008.[ncbi.nlm.nih.gov] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Spleen size roughly correlates with the WBC count and massive splenomegaly corresponds to poor prognosis.[lecturio.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] Concerned with the apparent intravascular hemolysis, a bone marrow biopsy showed hypercellularity and normal cytogenetics.[medbullets.com]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] Fig. 2: TRAP ; Fig. 3: hypercellular bone marrow with monotonous "fried egg" lymphocytes with abundant cytoplasm Cytology description Small / intermediate size cells with[pathologyoutlines.com] It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly. Lymphadenopathy is usually not seen.[ncbi.nlm.nih.gov]

  • Felty's Syndrome

    Splenectomy may be considered in those with massive splenomegaly or recurrent infections.[rheumaknowledgy.com] bone marrow.[ncbi.nlm.nih.gov] Ideally liver biopsy should be done but a diagnosis of nodular regenerative hyperplasia was assumed, as our patient had a clinical picture of rheumatoid arthritis with massive[autoimmunediseases.imedpub.com]

  • Myeloproliferative Disease

    Splenomegaly, sometimes massive, is a characteristic finding. Symptoms include the following: Splenic pain. Early satiety. Anemia. Bone pain. Fatigue. Fever.[northshore.org] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] Image shows: PV bone marrow (hypercellular) Picture of normal bone marrow for comparison Myeloproliferative Disorders: -Polycythemia Vera (PV) * Peripheral blood findings[quizlet.com]

  • Polycythemia Vera

    A "normal" hematocrit or hemoglobin level in a PV patient with massive splenomegaly should be considered indicative of an elevated red cell mass until proven otherwise.[theoncologyinstitute.com] bone marrow 5.[slideshare.net] Splenomegaly Massive splenomegaly is the most difficult complication of polycythemia vera to manage, since it is usually refractory to chemotherapy and not durably alleviated[cancertherapyadvisor.com]

  • Acute Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Leukemia

    With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder. The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype,[…][ncbi.nlm.nih.gov]

  • Chronic Neutrophilic Leukemia

    After anti-tuberculous therapy for 1 year, the patient underwent splenectomy for massive splenomegaly and progressive leukocytosis.[ncbi.nlm.nih.gov] bone marrow with predominant neutrophilic granulopoiesis (M:E is 20:1 or more), the number of myeloblasts and promyelocytes is not increased, myelocytes and mature neutrophils[atlases.muni.cz] These cases are characterized by a high number of mature neutrophils in peripheral blood (PB), a hypercellular bone marrow due to neutrophilic granulocyte proliferation and[learningcenter.ehaweb.org]

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