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92 Possible Causes for Hypercellular Bone Marrow, Mean Corpuscular Volume Increased

  • Pernicious Anemia

    Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[] […] in mean corpuscular volume and levels of ferritin and gastrin, and a decrease in vitamin B 12 levels.[] Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[]

  • Autoimmune Hemolytic Anemia

    Reticulocyte counts are usually elevated, and an increased MCV (mean corpuscular volume) (greater than 100 fl) can be seen, due to the larger size of reticulocytes in comparison[] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[] At 2 to 4 weeks after diagnosis, acute anemia, characterized by an elevated mean corpuscular volume (MCV), reticulocytosis, an undetectable haptoglobin level, and an increased[]

  • Myeloproliferative Disease

    The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[] This is in contrast to the myelodysplastic syndromes, in which the bone marrow is hypercellular, but the production is ineffective in one or more cell lines, resulting in[]

  • Paroxysmal Nocturnal Hemoglobinuria

    These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[] Thrombosis is the leading cause of death, but others may die of complications of bone marrow failure, renal failure, myelodysplastic syndrome, and leukemia.[]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[]

  • Congenital Hemolytic Anemia

    Mean corpuscular hemoglobin concentration (MCHC) is increased (35-38%) in approximately 50% of patients.[] Mean corpuscular volume (MCV) is usually normal except in cases of severe HS when the MCV may be mildly decreased.[]

  • Fetal Erythroblastosis

    Fetal erythroblastosis is a condition that occurs when the fetus and the mother are incompatible regarding the blood group, leading to fetal hemolytic anemia. Antigens in the RH0(D), Cc, Lutheran, EE, Diego, Xg, Kell, Kidd, Duffy and P systems are involved, but not incompatibilities of AB0 blood types. The mechanism of[…][]

  • Vitamin B12 Deficiency

    Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe[] Untreated B 12 deficiency can cause hypercellular and dysplastic bone marrow, which can be mistaken for signs of acute leukemia.[] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[]

  • Leukoerythroblastic Anemia

    mean corpuscular volume (macrocytic anemia: MCV 100 fL) Ethanol abuse Folate deficiency Vitamin B12 deficiency Myelodysplastic syndromes Acute myeloid leukemias (eg, erythroleukemia[] bone marrow with fibrosis in later stages Diagnosis polycythemia vera 3 major criteria or first two major criteria and two minor criteria Polycythemia vera major criteria[] Vitamin B12 and folate deficiency typically have megaloblastic changes, measurable serologic deficiency, and hypercellular bone marrow.[]

  • Myelodysplasia

    bone marrow Hello all, On my BMB report, for the bone marrow, it states "hypercellular ... 3 days, 8 hours ago CENTERS OF EXCELLENCE Would you like your treatment center[] The primary morphologic finding is that of dysplasia in a cytopenic patient and, typically, a hypercellular bone marrow.[] Myelodysplastic syndrome (MDS) comprises a group of clonal haematopoietic disorders characterized by peripheral blood cytopenias, bone marrow hypercellularity, and abnormal[]

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