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284 Possible Causes for Hypercellular Bone Marrow, Pallor

  • Hereditary Spherocytosis

    Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[ncbi.nlm.nih.gov] Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old.[ncbi.nlm.nih.gov] , jaundice Splenomegaly Diagnosis : Peripheral smear shows spherocytes with central pallor Osmotic fragility test Positive COOBS' test Pigmented gallstones (calcium bilirubinate[medlibes.com]

  • Leukemia

    Physical examination reveals pallor and multiple ecchymoses on his arms, legs, and trunk.[doi.org] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org]

  • Pernicious Anemia

    Abstract Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline.[ncbi.nlm.nih.gov] Here, I show that her physical ailments spanned 30 years and included sore mouth, pallor, paresthesias, the Lhermitte symptom, fever, headaches, fatigue, resting tachycardia[ncbi.nlm.nih.gov] Definition of pernicious anemia : a severe megaloblastic anemia that is marked by a progressive decrease in the number of red blood cells and by pallor, weakness, and gastrointestinal[merriam-webster.com]

  • Myeloproliferative Disease

    […] stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic infarction and perisplenitis Clinical symptoms can include the following: Pallor[emedicine.com] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[emedicine.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[bloodjournal.hematologylibrary.org] […] disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor[medical-dictionary.thefreedictionary.com]

  • Autoimmune Hemolytic Anemia

    An otherwise seemingly normal girl, who had developed limping at the age of 11 months old, referred to Namazi Hospital, Shiraz, Iran, due to pallor and latitude at the age[ncbi.nlm.nih.gov] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[jmedicalcasereports.com] A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com]

  • Acute Leukemia

    The first case is a 4-year-old girl who presented with pallor and abdominal enlargement.[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] The initial manifestations of leukemia are generally signs of bone marrow failure, such as pallor, fatigue, fever, bleeding, and infection related to peripheral blood cytopenias[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net]

  • Polycythemia Vera

    The symptoms are burning pain in the feet, hands, toes and fingers, sometimes associated with pallor, erythema, or cyanosis. Occasionally, it progresses to gangrene.[symptoma.com] bone marrow 5.[slideshare.net] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[ncbi.nlm.nih.gov]

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