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266 Possible Causes for Hypercellular Bone Marrow, Pallor

  • Chronic Myeloid Leukemia

    […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com]

  • Acute Leukemia

    The first case is a 4-year-old girl who presented with pallor and abdominal enlargement.[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] The initial manifestations of leukemia are generally signs of bone marrow failure, such as pallor, fatigue, fever, bleeding, and infection related to peripheral blood cytopenias[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    […] disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor[medical-dictionary.thefreedictionary.com] Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] Pallor, fatigue and stress dyspnea with activity are the usual manifestations.[orpha.net]

  • Polycythemia Vera

    The symptoms are burning pain in the feet, hands, toes and fingers, sometimes associated with pallor, erythema, or cyanosis. Occasionally, it progresses to gangrene.[symptoma.com] bone marrow 5.[slideshare.net] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net]

  • Myeloproliferative Disease

    […] stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic infarction and perisplenitis Clinical symptoms can include the following: Pallor[emedicine.medscape.com] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] […] physicians’ blinded opinion of patient symptoms. [17] Physical Examination Physical examination findings in patients with myeloproliferative disease may include the following: Pallor[emedicine.medscape.com]

  • Pyruvate Kinase Deficiency

    Symptoms of this condition include pale skin (pallor), jaundice, a yellowing of the white of the eyes (icterus), fatigue, and recurrent gallstones.[wohproject.org] A shortage of red blood cells to carry oxygen throughout the body leads to fatigue, pallor, and shortness of breath.[ghr.nlm.nih.gov] SIGNS AND SYMPTOMS Fatigue Lethargy Jaundice  Pallor (Paleness of skin)  Dyspnea (Shortness of breath) Tachycardia (Rapid heart rate ). (Grace et al., 2015). 7.[slideshare.net]

  • Congenital Hemolytic Anemia

    The typical clinical presentation is a patient with pallor, anemia, jaundice, and often splenomegaly.[ohsu.pure.elsevier.com] Clinical triad for hemolytic anemia Pallor or anemia Jaundice Splenomegaly (except in newborn and G6PD deficient) Increase in this component in the serum and urine reflects[brainscape.com] Microcytic Anisocytosis (size) Poikilocytosis (shape) Red cell fragments present in peripheral blood smear of Congenital Hemolytic Anemia Describe the extent of central pallor[brainscape.com]

  • Hereditary Spherocytosis

    Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old.[ncbi.nlm.nih.gov] He had been suffering from repeated attacks of jaundice, pallor, and splenomegaly since he was 10 years old.[ncbi.nlm.nih.gov] Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline.[ncbi.nlm.nih.gov] Here, I show that her physical ailments spanned 30 years and included sore mouth, pallor, paresthesias, the Lhermitte symptom, fever, headaches, fatigue, resting tachycardia[ncbi.nlm.nih.gov] A 42-year-old man presented with fatigue, pallor, and sustained abdominal distension that had persisted for 15 days.[ncbi.nlm.nih.gov]

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