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284 Possible Causes for Hypercellular Bone Marrow, Pancytopenia

  • Chronic Myeloid Leukemia

    We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] As a result of bone marrow infiltration, one or all series are suppressed, generating pancytopenia (anemia, neutropenia and thrombocytopenia).[pathologyatlas.ro]

  • Acute Leukemia

    Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com]

  • Myeloproliferative Disease

    Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] The major causes of associated morbidity and mortality are chronic intravascular hemolysis, pancytopenia, and venous thrombosis.[ncbi.nlm.nih.gov]

  • Leukemia

    Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com] […] familial exposure to radiation during cancer treatment and strategies to help limit incidental contact with potentially harmful byproducts. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com] Pancytopenia is typical and results in part from the physical replacement of normal marrow elements by the immature cells.[emedicine.medscape.com]

  • Alkylating Agent

    Acute leukemia developed 44 months after initial diagnosis and was preceded by a 10 month period of pancytopenia following cessation of thiotepa.[ncbi.nlm.nih.gov] marrow: hypercellular, normocellular or hypocellular marrow Often severely dysplastic changes in blood and marrow affecting two or more lineages Myelofibrosis (15% cases)[pathologyoutlines.com] High dosages cause pancytopenia and hemorrhagic cystitis .[en.wikipedia.org]

  • Amegakaryocytic Thrombocytopenia

    Congenital amegakaryocytic thrombocytopenia (CAMT) is characterised by neonatal thrombocytopenia, with reduced or absent bone marrow megakaryocytes, leading eventually to pancytopenia[ncbi.nlm.nih.gov] […] by normal-to-hypercellular bone marrow.[jahjournal.org] Patients initially present with isolated thrombocytopenia that subsequently progresses into pancytopenia.[ncbi.nlm.nih.gov]

  • LIG4 Syndrome

    (LIG4 syndrome) is a rare autosomal recessive disorder characterized by microcephaly, growth retardation, low birth weight, dysmorphic facial findings, immunodeficiency, pancytopenia[semanticscholar.org] Bone marrow examination revealed hypercellularity in both siblings. Alpha-fetoprotein levels were within normal limits.[bloodjournal.org] […] been described as ''bird-like'' (beak-like nose and micrognathia), growth and developmental delay, skin anomalies including photosensitivity and psoriatic-like lesions, and pancytopenia[orpha.net]

  • Pernicious Anemia

    The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[ncbi.nlm.nih.gov] Although her anemia was categorized as "normocytic, normochromic" by an electronic particle counter, evaluation of the pancytopenia confirmed unsuspected pernicious anemia[ncbi.nlm.nih.gov] The cobalamin deficiency was revealed by macrocytic pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Hairy cell leukemia typically presents with pancytopenia and often mimics aplastic anemia.[ncbi.nlm.nih.gov] Fig. 2: TRAP ; Fig. 3: hypercellular bone marrow with monotonous "fried egg" lymphocytes with abundant cytoplasm Cytology description Small / intermediate size cells with[pathologyoutlines.com] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[ncbi.nlm.nih.gov]

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