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233 Possible Causes for Hypercellular Bone Marrow, Pancytopenia

  • Paroxysmal Nocturnal Hemoglobinuria

    We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[doi.org] The major causes of associated morbidity and mortality are chronic intravascular hemolysis, pancytopenia, and venous thrombosis.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] Image shows: PV bone marrow (hypercellular) Picture of normal bone marrow for comparison Myeloproliferative Disorders: -Polycythemia Vera (PV) * Peripheral blood findings[quizlet.com] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com]

  • Chronic Myeloid Leukemia

    CASE PRESENTATION: We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading[ncbi.nlm.nih.gov] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] As a result of bone marrow infiltration, one or all series are suppressed, generating pancytopenia (anemia, neutropenia and thrombocytopenia).[pathologyatlas.ro]

  • Acute Leukemia

    Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Low numbers of all three blood cell counts is called pancytopenia. Risk Factors Doctors don't know why some cells become leukemic cells and others don't.[lls.org]

  • Leukemia

    This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org] Prolonged pancytopenia with severe BM aplasia was seen in a further 2 patients, one of whom died from a fungal pneumonia.[doi.org]

  • Pernicious Anemia

    The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[ncbi.nlm.nih.gov] Although her anemia was categorized as "normocytic, normochromic" by an electronic particle counter, evaluation of the pancytopenia confirmed unsuspected pernicious anemia[ncbi.nlm.nih.gov] The cobalamin deficiency was revealed by macrocytic pancytopenia.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow biopsy: Hypercellular marrow with panmyeloid hyperplasia Hypercellular marrow with increased megakaryocytes; myeloid cells are primarily neutrophils PAS stain - left[pathologyoutlines.com]

  • LIG4 Syndrome

    (LIG4 syndrome) is a rare autosomal recessive disorder characterized by microcephaly, growth retardation, low birth weight, dysmorphic facial findings, immunodeficiency, pancytopenia[semanticscholar.org] Bone marrow examination revealed hypercellularity in both siblings. Alpha-fetoprotein levels were within normal limits.[bloodjournal.org] […] been described as ''bird-like'' (beak-like nose and micrognathia), growth and developmental delay, skin anomalies including photosensitivity and psoriatic-like lesions, and pancytopenia[orpha.net]

  • Myelodysplasia

    Abstract An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and[ncbi.nlm.nih.gov] The primary morphologic finding is that of dysplasia in a cytopenic patient and, typically, a hypercellular bone marrow.[clinicaladvisor.com] […] manifests usually in childhood with neurologic disorder (cerebellar ataxia or atrophy) and/or hematologic disorder (marrow hypoplasia, myelodysplasia, acute myeloid leukemia, or pancytopenia[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] There is a stepwise evolution from an initial pre/fibrotic early stage, characterized by hypercellular bone marrow with absent or minimal reticulin fibrosis , to an overt[seer.cancer.gov] The clinical manifestations of PMF include splenomegaly, consequent to extramedullary hematopoiesis, pancytopenias, and an array of potentially debilitating constitutional[ncbi.nlm.nih.gov]

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