Create issue ticket

71 Possible Causes for Hypercellular Bone Marrow, Platelet Aggregation Abnormal

  • Myeloproliferative Disease

    Defects in glycoprotein (GP)IIb-IIIa or in its activation may cause abnormal platelet aggregation and a bleeding diathesis.[] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[] In all patients, circulating platelet aggregates were detected. Antiplatelet therapy resulted in prompt relief of pain and the disappearance of platelet aggregates.[]

  • Leukemia

    Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[] Marrow with too many blood-forming cells is said to be hypercellular. If too few of these cells are found, the marrow is called hypocellular.[]

  • Polycythemia Vera

    These abnormalities include brisk, absent, decreased or abnormal platelet aggregation response.[] bone marrow 5.[] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[] marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors.[]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[]

  • Essential Thrombocythemia

    aggregation: abnormal with adenosine diphosphate, epinephrine, and collagen Increased serum cobalamin, uric acid, LD, acid phosphatase Philadelphia chromosome negative ,[] ET is usually characterized by a hypercellular bone marrow, including increased numbers of megakaryocytes.[] Platelets aggregation studies • impaired platelet aggregation • Spontaneous platelets aggregation Bone marrow biopsy • Hypercellular marrow (90%) • Megakaryocytic hyperplasia[]

  • Secondary Polycythemia

    Platelet aggregation studies in ET are often abnormal. Signs and Symptoms The clinical signs and symptoms are similar to those of PV.[] The renal biopsy revealed membranous nephropathy, and the bone marrow biopsy disclosed hypercellular marrow with mild panhyperplasia.[] Bone marrow is hypercellular with prominent megakaryocytes. Serum erythropoietin level is usually low. Blood viscosity is increased.[]

  • Chronic Neutrophilic Leukemia

    A peripheral blood smear did not show either platelet aggregation or giant platelets.[] bone marrow with predominant neutrophilic granulopoiesis (M:E is 20:1 or more), the number of myeloblasts and promyelocytes is not increased, myelocytes and mature neutrophils[] These cases are characterized by a high number of mature neutrophils in peripheral blood (PB), a hypercellular bone marrow due to neutrophilic granulocyte proliferation and[]

  • Microangiopathic Hemolytic Anemia

    […] that remain abnormally large platelet aggregation. 11.[] An attempt to demonstrate possible in vitro deficiency of the platelet aggregation-prohibiting factor in the patient's plasma was unsuccessful.[] PATHOGENESIS 1) Endothelial injury and activation. 2) Platelet aggregation Both cause vascular obstruction and vasoconstriction Precipitate distal ischaemia. 8.[]

Further symptoms

Similar symptoms