Create issue ticket

62 Possible Causes for Hypercellular Bone Marrow, Platelet Aggregation Abnormal

  • Myeloproliferative Disease

    Defects in glycoprotein (GP)IIb-IIIa or in its activation may cause abnormal platelet aggregation and a bleeding diathesis.[ncbi.nlm.nih.gov] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] In all patients, circulating platelet aggregates were detected. Antiplatelet therapy resulted in prompt relief of pain and the disappearance of platelet aggregates.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[lecturio.com] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Polycythemia Vera

    bone marrow 5.[slideshare.net] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[ncbi.nlm.nih.gov] Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic and megakaryocytic proliferation with[pathologyoutlines.com]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[ncbi.nlm.nih.gov] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Essential Thrombocythemia

    aggregation: abnormal with adenosine diphosphate, epinephrine, and collagen Increased serum cobalamin, uric acid, LD, acid phosphatase Philadelphia chromosome negative ,[labce.com] ET is usually characterized by a hypercellular bone marrow, including increased numbers of megakaryocytes.[labce.com] Platelets aggregation studies • impaired platelet aggregation • Spontaneous platelets aggregation Bone marrow biopsy • Hypercellular marrow (90%) • Megakaryocytic hyperplasia[slideshare.net]

  • Leukemia

    With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder. The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype,[…][ncbi.nlm.nih.gov]

  • Microangiopathic Hemolytic Anemia

    […] that remain abnormally large platelet aggregation. 11.[slideshare.net] An attempt to demonstrate possible in vitro deficiency of the platelet aggregation-prohibiting factor in the patient's plasma was unsuccessful.[ncbi.nlm.nih.gov] PATHOGENESIS 1) Endothelial injury and activation. 2) Platelet aggregation Both cause vascular obstruction and vasoconstriction Precipitate distal ischaemia. 8.[slideshare.net]

  • Vitamin B12 Deficiency

    The hematological changes in vitamin B12 deficiency present as megaloblastic anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and[ncbi.nlm.nih.gov] Untreated B 12 deficiency can cause hypercellular and dysplastic bone marrow, which can be mistaken for signs of acute leukemia.[pharmacytimes.com] abnormal activation of the coagulation followed by microangiopathy as well as neutropenia and thrombocytopenia.[ncbi.nlm.nih.gov]

  • Chronic Neutrophilic Leukemia

    A peripheral blood smear did not show either platelet aggregation or giant platelets.[kjim.org] bone marrow with predominant neutrophilic granulopoiesis (M:E is 20:1 or more), the number of myeloblasts and promyelocytes is not increased, myelocytes and mature neutrophils[atlases.muni.cz] These cases are characterized by a high number of mature neutrophils in peripheral blood (PB), a hypercellular bone marrow due to neutrophilic granulocyte proliferation and[learningcenter.ehaweb.org]

Further symptoms

Similar symptoms