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100 Possible Causes for Hypercellular Bone Marrow, Splenic Infarction

  • Myeloproliferative Disease

    infarction and perisplenitis Clinical symptoms can include the following: Pallor (except in patients with polycythemia vera) Plethora secondary to polycythemia Petechiae[] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[] […] secondary to gouty arthritis that is secondary to hyperuricemia Priapism, tinnitus, or stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic[]

  • Polycythemia Vera

    ) splenic infarction venous thromboses acute superior mesenteric venous thrombosis dural venous sinus thrombosis Budd-Chiari syndrome cerebrovascular events myocardial infarction[] bone marrow 5.[] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[]

  • Chronic Phase of Chronic Myeloid Leukemia

    Fever, susceptibility to infection, lymphadenopathy, bone pain, infiltration of extramedullary tissues, prominent splenomegaly, splenic infarction, thrombosis, retinal hemorrhages[] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] […] enlargement *Splenic infarcts Histamine perivascular infiltrate of neutrophils in the dermis fever and painful maculonodular violaceous lesions trunk, arms, legs, and face[]

  • Chronic Myeloid Leukemia

    Splenectomy may be done for palliation in patients with late stage CML complaining of pain and discomfort due to the enlarged spleen and splenic infarcts.[] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] In some cases, a computed tomography (CT) scan of the abdomen or an ultrasound exam may be useful to evaluate the size of the spleen and/or to diagnosis a splenic infarction[]

  • Sickle Cell Disease

    Massive splenic infarction (MSI) is a rare complication of sickle cell disease, as the spleen generally atrophies within the first few years of life.[] These include splenic infarction, pulmonary involvement, acute chest syndrome, and orbital compression syndrome.[] Splenic infarction and subsequent functional asplenia tend to occur early in the disease. The hepatobiliary and renal systems are also commonly involved.[]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[]

  • Primary Myelofibrosis

    Splenic infarction: usually self-limited and treated with fluids and opiate analgesics. Refractory cases may require splenectomy or splenic irradiation.[] A biopsy of the lytic lesion was done, revealing hypercellular bone marrow with hyperplastic granulopoiesis associated with megakaryocytic proliferation and atypia, accompanied[] There is a stepwise evolution from an initial pre/fibrotic early stage, characterized by hypercellular bone marrow with absent or minimal reticulin fibrosis, to an overt fibrotic[]

  • Hereditary Spherocytosis

    An ultrasound scan confirmed splenomegaly with areas of splenic infarction. Subsequent tests suggested possible Epstein-Barr virus infection.[] Concomitant hereditary spherocytosis and sickle cell trait, although extremely rare, could potentially lead to splenic sequestration or infarction.[] We report here the first case of splenic infarction in a child with hereditary spherocytosis and sickle cell trait while flying on a commercial aircraft.[]

  • Infectious Mononucleosis

    Splenic infarction is an uncommon complication of infectious mononucleosis, and may have a wide range of clinical presentations, from dramatic to more subtle.[] A bone marrow aspirate ruled out haemophagocytic syndrome.[] An 18-year-old woman with infectious mononucleosis developed splenic infarction and severe anemia.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses.[] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[] This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal[]

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