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91 Possible Causes for Hypercellular Bone Marrow, Splenic Infarction

  • Chronic Myeloid Leukemia

    Splenectomy may be done for palliation in patients with late stage CML complaining of pain and discomfort due to the enlarged spleen and splenic infarcts.[lecturio.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] In some cases, a computed tomography (CT) scan of the abdomen or an ultrasound exam may be useful to evaluate the size of the spleen and/or to diagnosis a splenic infarction[clinicaladvisor.com]

  • Polycythemia Vera

    Radiographic manifestations are varied and non-specific and can affect a number of system, including: splenomegaly organ infarcts e.g. splenic infarcts features of extramedullary[radiopaedia.org] bone marrow 5.[slideshare.net] Early satiety can occur in patients with splenomegaly , because of gastric filling being impaired by the enlarged spleen or, rarely, as a symptom of splenic infarction.[emedicine.medscape.com]

  • Myeloproliferative Disease

    infarction and perisplenitis Clinical symptoms can include the following: Pallor (except in patients with polycythemia vera) Plethora secondary to polycythemia Petechiae[emedicine.medscape.com] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] infarction and perisplenitis In many patients, abnormal blood counts are noted on a blood test performed for other reasons.[emedicine.medscape.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    Fever, susceptibility to infection, lymphadenopathy, bone pain, infiltration of extramedullary tissues, prominent splenomegaly, splenic infarction, thrombosis, retinal hemorrhages[symptoma.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] […] enlargement *Splenic infarcts Histamine perivascular infiltrate of neutrophils in the dermis fever and painful maculonodular violaceous lesions trunk, arms, legs, and face[slideshare.net]

  • Felty's Syndrome

    L eft upper quadrant pain (due to splenomegaly or splenic infarcts).[medical-institution.com] bone marrow.[ncbi.nlm.nih.gov] infarct 7.[de.slideshare.net]

  • Sickle Cell Disease

    These include splenic infarction, pulmonary involvement, acute chest syndrome, and orbital compression syndrome.[ncbi.nlm.nih.gov] Splenic infarction and subsequent functional asplenia tend to occur early in the disease. The hepatobiliary and renal systems are also commonly involved.[radiopaedia.org] infarcts then cause autosplenectomy.[patient.info]

  • Acute Lymphoblastic Leukemia

    On the basis of blood tests, bone marrow biopsy and imaging, a diagnosis of ALL complicated by massive hepatosplenomegaly with splenic infarctions was made.[ncbi.nlm.nih.gov] The leukemic cells of the hypercellular bone marrow then spill into the blood circulation and are visible on routine CBCs .[lecturio.com] The bone marrow was hypercellular, with 64% blasts, which were large in size and showed low nucleus: cytoplasm ratio, monocytoid features, and blue-gray cytoplasm; 80% of[casesjournal.biomedcentral.com]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[ncbi.nlm.nih.gov] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses.[ncbi.nlm.nih.gov] Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal[ncbi.nlm.nih.gov]

  • Essential Thrombocythemia

    The patient had experienced previous events of thrombosis, splenic infarction with venous thrombosis, and myocardial infarction.[ncbi.nlm.nih.gov] ET is usually characterized by a hypercellular bone marrow, including increased numbers of megakaryocytes.[labce.com] The patient also had a splenic infarction and a subphrenic hematoma.[ncbi.nlm.nih.gov]

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