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377 Possible Causes for Hypercellular Bone Marrow, Thrombocytopenia

  • Leukemia

    Anemia and thrombocytopenia are the major adverse prognostic variables. CLL has no standard staging system.[web.archive.org] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    This case raises caution for heparin-induced thrombocytopenia in paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[bloodjournal.hematologylibrary.org] The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants are indicated but thrombocytopenia may increase the bleeding[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    […] by imatinib, it was intriguing to analyze the role of platelet-derived growth factor receptor-α in relation to imatinib treatment in the development of imatinib-induced thrombocytopenia[ncbi.nlm.nih.gov] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Immune thrombocytopenia (ITP) was also diagnosed in this patient following the detection of antiplatelet autoantibodies.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    This is the second description of pernicious anemia associated with autoimmune thrombocytopenia.[ncbi.nlm.nih.gov] After 1 month of vitamin B12 treatment, hemoglobin and white blood cell count remain normal but thrombocytopenia persists and was considered as immunologic from SLE origin[ncbi.nlm.nih.gov] A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    Transfusion of blood products is indicated to compensate for anemia and thrombocytopenia.[symptoma.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Thrombocytopenia, hepatotoxicity, hyperbilirubinemia and hyperglycemia were the most common hematologic and non-hematologic adverse events (AEs).[haematologica.org]

  • Acute Leukemia

    A 29-year-old woman was admitted with thrombocytopenia, blast-like cells in the peripheral blood and a coagulation disorder.[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Improving prevention of thrombosis appears a major goal in patients whose frequent conditions of thrombocytopenia impede an adequate delivery of anticoagulant therapy.[ncbi.nlm.nih.gov]

  • Fetal Erythroblastosis

    Schistocytes, as a sign of disseminated intravascular coagulation and burr cells, are present, as well as neutropenia and thrombocytopenia.[symptoma.com] Management of severe alloimmune thrombocytopenia in the newborn. Arch Dis Child Fetal Neonatal Ed 2000 ; 82 : F173 –5. Ohlsson A, Lacy JB.[doi.org] It is possible for a newborn with this disease to have neutropenia and neonatal alloimmune thrombocytopenia as well. Hemolysis leads to elevated bilirubin levels.[en.wikipedia.org]

  • Microangiopathic Hemolytic Anemia

    Both the hemolysis and the thrombocytopenia spontaneously improved after the initiation of hemodialysis.[ncbi.nlm.nih.gov] In patients with cancer, systemic microvascular metastases and bone marrow involvement can cause microangiopathic hemolytic anemia and thrombocytopenia.[ncbi.nlm.nih.gov] Microangiopathic hemolytic anemia and thrombocytopenia should be remarked as a complication in patients with congenital heart disease.[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    Patients should be monitored for leukopenia and thrombocytopenia. Complications from long-term usage are not yet known. Efficacy in children has not been proven.[symptoma.com] The commonest side effects included neutropenia and thrombocytopenia.[doi.org] Hydroxyurea is a leukemogen and causes neutropenia and thrombocytopenia. It is also a teratogen and should not be given to females of child-bearing age.[msdmanuals.com]

  • Autoimmune Hemolytic Anemia

    Evans syndrome is a rare condition manifested by combined autoimmune hemolytic anemia (AIHA) and thrombocytopenia or neutropenia.[ncbi.nlm.nih.gov] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[jmedicalcasereports.com] We report a case of renal urothelial cancer inducing Coombs-positive warm AIHA and severe thrombocytopenia that was responsive to nephroureterectomy.[ncbi.nlm.nih.gov]

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