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89 Possible Causes for Hypercellular Bone Marrow, Uric Acid Increased

  • Chronic Myeloid Leukemia

    Gout – increased cell turnover excess purines broken down to uric acid Increased susceptibility to infections – functional immune cells Shortness of breath/fatigue – anaemia[geekymedics.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Sodium bicarbonate may be used to alkalinize the urine to increase uric acid excretion.[lecturio.com]

  • Polycythemia Vera

    Increased uric acid Presence of the JAK2 mutation Hypercellular bone marrow 5.[slideshare.net] […] turnover of red cells, leukocytes, and platelets with the attendant increase in uric acid and cytokine production.[theoncologyinstitute.com] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    acid – gout/uropathy Histamine increase with basophil 90% In normal cells, two red and two green signals indicate the location of the normal ABL and BCR genes, respectively[slideshare.net] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net]

  • Myeloproliferative Disease

    Furthermore, ruxolitinib also decreased plasma levels of N-terminal pro-brain natriuretic peptide, von Willebrand antigen, ristocetin-cofactor activity and uric acid, and[err.ersjournals.com] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] -Total protein, BUN, creatinine, uric acid elevated -Hypercalcemia in 1/3 of patients -40% Bence Jones proteinuria * need sulfosalicylic acid urine test to detect.[quizlet.com]

  • Acute Lymphoblastic Leukemia

    The leukemic cells of the hypercellular bone marrow then spill into the blood circulation and are visible on routine CBCs .[lecturio.com] This is done to maintain good flow through the kidneys to prevent renal damage from tumor lysis and to increase the solubility of uric acid that is excreted in the urine.[clinicaladvisor.com] The bone marrow was hypercellular, with 64% blasts, which were large in size and showed low nucleus: cytoplasm ratio, monocytoid features, and blue-gray cytoplasm; 80% of[casesjournal.biomedcentral.com]

  • Leukemia

    acid. 21 Immunosuppression from chemotherapy, hematopoietic stem cell transplantation, or the leukemia itself may increase the risk of serious infections.[aafp.org] […] renal failure, and includes aggressive intravenous fluid administration plus allopurinol (Zyloprim) or rasburicase (Elitek), a recombinant urate oxidase that breaks down uric[aafp.org]

  • Autoimmune Hemolytic Anemia

    Warm antibody autoimmune hemolytic anemia (AIHA) results from targeted antibodies towards the red blood cells (RBCs) and can be either idiopathic or secondary to certain diseases, such as autoimmune disorders or malignancy, drugs, or infection. Patients with DiGeorge syndrome are particularly vulnerable to[…][ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    The objective of this study was to evaluate health-related quality of life (HRQoL) and behavioral functioning in pediatric patients with hereditary spherocytosis (HS). A cross-sectional study was conducted in 132 Dutch children and adolescents with HS and aged 8-18 years of whom 48 underwent splenectomy prior to[…][ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Pernicious anemia (PA), as many other autoimmune disorders, has a trend to appear in other members of the family of the affected patients. Although this fact has been recognized since some decades ago, less is known about the frequency with which the abnormalities detected in the patients appear also in their[…][ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    Depletion of haptoglobin (Hp) and hemopexin (Hx) with increase in free hemoglobin and heme are important etiologies of vaso-occlusive complications in sickle cell disease (SCD). This study is the first to show an association between clinical improvement in SCD and repletion of Hp and Hx by therapeutic plasma exchange[…][ncbi.nlm.nih.gov]

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