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104 Possible Causes for Hypercellular Bone Marrow, Vitamin B12 Increased

  • Polycythemia Vera

    Polycythemia Vera Laboratory findings Elevated Hct – often 60% Increased WBCs and platelets Serum EPO levels are low Decreased iron stores (Ferritin) Increased Vitamin B12[] In many patients, the LAP level is also increased, as is the uric acid level. Elevated serum vitamin B12 or B12-binding capacity may be present.[] Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.[]

  • Acute Leukemia

    ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[] Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[] Bone marrow aspiration demonstrated hypercellular marrow (nucleated cell count 1.84 104/μL) and 89.0% of blast-like cells of all nucleated cells.[]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[]

  • Myeloproliferative Disease

    The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[] Image shows: PV bone marrow (hypercellular) Picture of normal bone marrow for comparison Myeloproliferative Disorders: -Polycythemia Vera (PV) * Peripheral blood findings[] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[] Concerned with the apparent intravascular hemolysis, a bone marrow biopsy showed hypercellularity and normal cytogenetics.[] The degree of marrow failure may vary from severe aplastic anemia to a decrease in the number of hematopoietic stem cells.[]

  • Chronic Neutrophilic Leukemia

    Increased serum vitamin B12, increased serum urine acid levels and increased leukocyte alkaline phosphatase activity are the associated features in the absence of fever or[] bone marrow with predominant neutrophilic granulopoiesis (M:E is 20:1 or more), the number of myeloblasts and promyelocytes is not increased, myelocytes and mature neutrophils[] WBC count 25 10 9 /L with neutrophilia, increased serum vitamin B12 Treatment Optimal treatment unknown Microscopic (histologic) description Bone marrow : hypercellular with[]

  • Acute Myelocytic Leukemia

    The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow.[] marrow biopsy: Markedly hypercellular marrow with heterogeneous cells, including immature monocytes (irregular nuclei and prominent nucleoli) and neutrophils Stains: Chloroacetate[] When the bone marrow is hypercellular or normocellular and easy to aspirate, bone marrow biopsy is usually not essential and cytological examination of smears is sufficient[]

  • Chronic Eosinophilic Leukemia

    Additional tests that may be ordered to confirm a CEL diagnosis are: Vitamin B12 (increased in CEL) Tryptase (increased in CEL) Interleukin 5 (normal levels in CEL Uric acid[] Histology Hypercellular bone marrow with predominatnt eosinophilic proliferation, the number of myeloblasts may be increased between 5 – 19%, Charcot-Leyden crystals are often[] The serum vitamin B12 levels were grossly elevated, and Philadelphia chromosome study was negative. Thus, a diagnosis of chronic eosinophilic leukemia was made.[]

  • Vitamin B12 Deficiency Anemia

    H pylori seems to be an etiologic factor in vitamin B12 deficiency, since anemia was cured and the level of vitamin B12 in the serum increased as a result of its eradication[] Bone Marrow aspiration and biopsy showed hypercellularity with megaloblastic changes. Flow cytometry showed no evidence of increase blast cells.[] But increasing your vitamin B12 levels is a key thing you can do.[]

  • Macrocytic Anemia

    Serum vitamin B12 was markedly increased and folate concentration was above normal, as were urinary homocystine and methylmalonic acid.[] The bone marrow biopsy showed a slightly hypercellular bone marrow with normal granulopoiesis, normal megakaryopoiesis and a mild dyserythropoiesis without any ring-sideroblasts[] But increasing your vitamin B12 levels is a key thing you can do.[]

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