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220 Possible Causes for Hypercholesterolemia, Tendon Xanthomas

  • Heterozygous Familial Hypercholesterolemia

    Sixty-two patients had positive physical examination findings for Achilles tendon xanthomas.[ajronline.org] Familial Hypercholesterolemia".[en.wikipedia.org] Tendon xanthomas are cholesterol deposits on tendons that can be felt as bumps on the surface of the backs of the heels and fingers.[ahajournals.org]

  • Familial Hypercholesterolemia

    The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX.[ncbi.nlm.nih.gov] PURPOSE OF REVIEW: Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia[ncbi.nlm.nih.gov] BACKGROUND AND AIMS: The effect of LDLc lowering with PCSK9 antibodies on tendon xanthomas (TX) is unknown.[ncbi.nlm.nih.gov]

  • Hypercholesterolemia

    Xanthomas are noted commonly on the Achilles tendons and metacarpal phalangeal extensor tendons of the hands.[emedicine.medscape.com] Civeira F; International Panel on Management of Familial Hypercholesterolemia. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia.[ghr.nlm.nih.gov] Achilles tendon thickening is the early characteristic of Achilles tendon xanthomas.[ncbi.nlm.nih.gov]

  • Homozygous Familial Hypercholesterolemia

    The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis[ncbi.nlm.nih.gov] […] heterozygous hypercholesterolemia.[ncbi.nlm.nih.gov] Xanthomas The high cholesterol level may result in the build-up of cholesterol deposits in the skin and tendons as well – xanthomas.[aoporphan.com]

  • Familial Hyperlipidemia

    His physical exam is normal and there is no tendon xanthomas or corneal arcus. Familial hypercholesterolemia (FH) is suspected.[knowledge.statpearls.com] Familial Hypercholesterolemia".[en.wikipedia.org] Image of tendon xanthoma, a pathognomonic physical examination finding in patients with familial hypercholesterolemia. Figure.[jaoa.org]

  • Sterol 27-Hydroxylase Deficiency

    […] levels may also be reduced or normal), neurological symptoms and tendon xanthomas.[symptoma.com] Differential diagnosis Differential diagnoses include other causes of xanthomata such as sitosterolemia and hyperlipemia (especially type IIa, also known as familial hypercholesterolemia[orpha.net] If hypercholesterolemia is not controlled with CDCA, an HMG-CoA reductase inhibitor ("statins" such as simvastatin) can also be used.[en.wikipedia.org]

  • Cerebrotendinous Xanthomatosis

    A physical examination revealed prominent Achilles tendon thickness and plantar xanthomas.[ncbi.nlm.nih.gov] Two unrelated individuals were referred to Lipid Clinics in The Netherlands and Chile with extreme xanthomatosis and hypercholesterolemia.[ncbi.nlm.nih.gov] It should be noted that up to 30% of patients with XCT do not present with tendon xanthomas, as in the case reported.[mdsabstracts.org]

  • Hyperlipoproteinemia Type 4

    Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[medicowesome.com] Familial combined hypercholesterolemia type II b presenting with tuberous xanthoma, tendinous xanthoma and pityriasis rubra pilaris-like lesions.[ijdvl.com] Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[acc.org]

  • Disorder of Lipid Metabolism

    Familial hypercholesterolaemia (FH), which may present with xanthelasma ( Fig 67.1 ), tendon xanthomas, severe hypercholesterolaemia and premature coronary heart disease,[clinicalgate.com] Hypertriglyceridemia Lipoprotein lipase deficiency/Type Ia Familial apoprotein CII deficiency/Type Ib Familial hypercholesterolemia/Type IIa Combined hyperlipidemia/Type[en.wikipedia.org] Corneal arcus is common, and tendon xanthomas involving the dorsum of the hands, elbows, knees, and especially the Achilles tendons are present in 75% of patients.[thoracickey.com]

  • Hyperlipoproteinemia

    Achilles tendon xanthomas are often associated with type II hyperlipoproteinemia, in which low-density lipoprotein derived from the circulation accumulates in the tendons.[ncbi.nlm.nih.gov] To describe our experience with lipoprotein apheresis in patients with severe hypercholesterolemia or with hyperlipoproteinemia(a).[ncbi.nlm.nih.gov] Abstract We describe an adult patient with type IIa hyperlipoproteinemia, presenting with Achilles tendon xanthomas, cataracts, dementia, ataxia, pyramidal tract signs, and[ncbi.nlm.nih.gov]

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