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491 Possible Causes for Hyperchromatic Nuclei

  • Infectious Mononucleosis

    nuclei).[] , the paracortical areas usually show a mixture of small and large lymphoid cells, but without significant cytologic atypia (the latter manifested by highly irregular or hyperchromatic[]

  • Childhood Soft Tissue Sarcoma

    Large, lobulated, and hyperchromatic nuclei as well as atypical mitoses are characteristic of undifferentiated, pleomorphic rhabdomyosarcoma.[]

  • Pleomorphic Rhabdomyosarcoma

    Fine needle aspiration biopsy of a lytic lesion in the right iliac wing showed a pleomorphic population of clusters and single cells with hyperchromatic nuclei; granular,[] nuclei.[] Anaplastic malignant neoplasm composed of proliferating atypical spindle cells with pleomorphic and hyperchromatic nuclei and eosinophilic cytoplasm, with scattered giant[]

  • Villous Adenoma of the Colon

    nuclei, (pseudo)stratified nuclei, nucleolus, decreased mucosecretion and mitosis.[] hyperchromatic and elongated in shape; stratification of nuclei; varies degree of dysplasia.[] LM nuclear changes - esp. at the surface (hyperchromatic elongated nuclei or round cleared nuclei), nuclear crowding/pseudostratification, /- loss of nuclear polarity, loss[]

  • Translocation Renal Cell Carcinoma

    Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in[] (b) Cells with abundant pale to vacuolated cytoplasm and hyperchromatic nuclei (Geimsa x400).[] The cells were large, round to polygonal with abundant, finely granular or clear - vacuolated cytoplasm and moderately enlarged, round, hyperchromatic nuclei with occasional[]

  • Desmoplastic Small Round Cell Tumor

    The tumor cells were medium sized, with hyperchromatic nuclei and moderate amounts of cytoplasm.[] Fine-needle aspiration cytology showed variably cohesive clusters of small cells with hyperchromatic nuclei and fine granular chromatin.[] Biopsy of the mass shows nests of poorly differentiated small round cells with little cytoplasm and hyperchromatic nuclei that are surrounded by desmoplastic stroma.[]

  • Papillary Serous Cystadenocarcinoma of the Ovary

    The tumor cells were large with small hyperchromatic nuclei and abundant clear cytoplasm [Figure 2] b and d.[] Figure 1: Small groups of cells with enlarged and hyperchromatic nuclei (400x).[] Furthermore, seen are few bizarre cells with irregular hyperchromatic nuclei and atypical mitosis (6-8/10 hpf). Numerous psammoma bodies were also seen [Figure 3] .[]

  • Gastric Leiomyosarcoma

    Data which favor the diagnosis of leiomyosarcoma are: (1) spindle-shaped cells with malignant looking nuclei; (2) cells with extremely long, fiber-like cytoplasms and hyperchromatic[] Histological examination showed interlacing bundles of spindle cells, ill-defined cell borders, elongated hyperchromatic nuclei with marked pleomorphism and paranuclear vacuolization[] The nuclei of the spindle cells were hyperchromatic, pleomorphic and multinucleated [Figure - 3].[]

  • Penile Intraepithelial Neoplasia

    Histologic sections reveal epidermal acanthosis and atypical keratinocytes displaying individual cell keratinization and atypical nuclei, including large hyperchromatic nuclei[] H&E: note the pleomorphic, hyperchromatic keratinocytes with multiple nuclei and scattered abnormal mitotic figures. Figure 3.[] Routine hematoxylin and eosin (H&E) staining will show pleomorphic, hyperchromatic keratinocytes with multiple nuclei and occasional abnormal mitotic figures ( Figure 2 ).[]

  • Thyroid Follicular Adenoma

    (large hyperchromatic nuclei in clusters) Rarely contains mature fat ( Mod Pathol 1989;2:506 ), signet ring cells ( Acta Cytol 2004;48:87 ), extensive bone metaplasia ( J[] In some cases mitoses, bizarre and giant hyperchromatic nuclei found between hyperplastic nodules, and fibrosis with irregularities that may mimic capsular invasion are found[] nuclei that lacked features of PTC nuclei.[]

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