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684 Possible Causes for Hyperchromatic Nuclei

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  • Malignant Neoplasm

    Nuclei are hyperchromatic or vesicular and elongated. Nuclei may be pleomorphic and contain multiple nucleoli. Mitotic activity is brisk and atypical forms may be seen.[] Increased nuclear DNA content with subsequent dark staining on H and E slides (hyperchromatism). Prominent nucleoli or irregular chomatin distribution within nuclei.[] The spindle cells are usually mildly to moderately atypical, although cells with larger, more hyperchromatic nuclei are often seen.[]

  • Desmoplastic Small Round Cell Tumor

    The tumor cells were medium sized, with hyperchromatic nuclei and moderate amounts of cytoplasm.[] Fine-needle aspiration cytology showed variably cohesive clusters of small cells with hyperchromatic nuclei and fine granular chromatin.[] nuclei Small nucleoli High mitotic rate, with atypical mitoses (translocation sarcoma) ANCILLARY TESTS Immunohistochemistry Only gold members can continue reading.[]

  • Human Papillomavirus Infection

    Scattered, single cells of smaller size with hyperchromatic nuclei, nuclear enlargement, abnormal chromatin clumping and irregular nuclear contours are also seen.[] The cytopathologist identifies several large squamous cells with orangeophilic cytoplasm and large, crinkled nuclei.[]

  • Invasive Ductal Carcinoma

    The tumor cells have mild to moderately pleomorphic, hyperchromatic nuclei and distinct nucleoli. Mitotic figures are not conspicuous.[]

  • Solitary Fibrous Tumor

    Some cells are pleomorphic (arrow 5) with bizarre hyperchromatic nuclei. Solitary fibrous tumors present a variable number of mitotic figures as well as pleomorphism.[] Our patient’s sample showed hyperchromatic nuclei and 5 mitotic figures per 10 HPF, placing our case in the category at risk of an aggressive course of disease.[] It has a herringbone-like growth pattern and consists of scant cytoplasm, hyperchromatic nuclei, and variable nucleoli [ 5 ]. It also presents immunonegativity for CD34.[]

  • Malignant Peripheral Nerve Sheath Tumor

    Microscopically, the tumor was composed of pleomorphic spindle cells with hyperchromatic nuclei and mitogenic figures.[] nuclei with tapered ends, whorled structures, epithelioid appearance of perivascular tumor cells, and immunohistochemical or ultrastructural evidence of Schwann cell differentiation[] Spindle cells showed hyperchromatic nuclei with indistinct pale cytoplasm and increased mitotic activity (6 per high power field).[]

  • Lymphomatoid Papulosis

    nuclei that may mimic Reed-Sternberg cells Also mixed inflammatory infiltrate Type B : Relatively small hyperchromatic lymphocytes with complex nuclear membranes Microscopic[] nuclei.[] There were cells with large irregularly shaped hyperchromatic nuclei. A few mitotic figures were also seen.[]

  • Palpebral Nevus

    Histopa - thology showed plump spindle-shaped, pigmented melanocytic cells revealing a branching network of dendritic processes with small, elongated, and hyperchromatic nuclei[] In well-differentiated tumors, the cells are polygonal with abundant acidophilic cytoplasm and hyperchromatic nuclei with various size and staining properties, dyskeratotic[] Histologically, the lesion is well-circumscribed and shows two types of cells: The peripheral basophilic cells with hyperchromatic nuclei and the pale glycogen-rich clear[]

  • Well-Differentiated Liposarcoma

    Histopathology Atypical lipomatous tumour consists of adult fat with enlarged atypical hyperchromatic nuclei.[] Histologically, these tumors show lipoblasts (irregularly shaped cells with hyperchromatic nuclei) and lipocytes. 4 Although these tumors are known to locally recur if marginally[] nuclei Can be markedly atypical Cellularity is low and mitotic figures are uncommon Atypical cells are more commonly found in fibrous septa and in a perivascular distribution[]

  • Placental-Site Trophoblastic Tumor

    nuclei and eosinophilic cytoplasm Tumor cells frequently exhibit marked atypia with large convoluted, hyperchromatic nuclei and eosinophilic to clear cytoplasm At the periphery[] The predominant type of cell in PSTT is implantation-site-intermediate trophoblast which is characteristically a large polyhedral cell with irregular hyperchromatic nuclei[] Decidual cells have more distinct cell membranes, basophilic cytoplasm and pale, uniform nuclei in contrast to the amphophilic or deeply eosinophilic cytoplasm and hyperchromatic[]

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