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42 Possible Causes for Hyperconvex Nails, Single Transverse Palmar Crease, Widely Spaced Nipples

  • Wolf Hirschhorn Syndrome

    spaced nipples Hypoplasia or duplication of thumbs and great toes Talipes equinovarus Hypoplasia of pubic bones Vertebral and rib anomalies Defective calvaria ossification[emedicine.medscape.com] [ncbi.nlm.nih.gov] Skin Hyperconvex Nails In the hands, notable features include dermal ridges, simian crease in the palms, and hyperconvex nails .[symptoma.com] transverse palmar crease, broad hands, fifth digit clinodactyly), joint hyperflexibility, redundant neck skin, pelvic dysplasia, wide gap between first and second toes (sandal[pathophys.org]

  • Pitt-Hopkins Syndrome

    Wide-spaced nipples and sacral dimple have been described in rare cases.[ncbi.nlm.nih.gov] nails Lymphoma, fetal finger pads, slender feet with short IV/V metatarsals, dislocated hips, and frontal cowlick Test result: AS methylation NA NA Normal Normal Normal NA[ncbi.nlm.nih.gov] Minor anomalies occasionally seen are accessory nipples, hypoplastic genitalia (small penis in boys) and undescended testes.[ncbi.nlm.nih.gov]

  • Schinzel-Giedion Syndrome

    spaced nipples; Supernumerary nipple ABDOMEN: [Pancreas]; Hyperechogenic pancreas; [Gastrointestinal]; Severe gastroesophageal reflux; Malrotation; Poor feeding GENITOURINARY[findzebra.com] nails mental retardation seizures opisthotonus spasticity hypsarrhythmia cerebral atrophy ventriculomegaly thin corpus callosum hypothryoidism diabetes insipidus tumor predisposition[humpath.com] transverse palmar crease 0000954 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Talipes equinovarus Club feet Club foot Clubfeet Clubfoot [ more ][rarediseases.info.nih.gov]

  • Short stature-Valvular Heart Disease-Characteristic Facies Syndrome

    spaced nipples Pectus excavatum or pectus carinatum (up to 90% have both, usually pectus carinatum superiorly and pectus excavatum inferiorly) Scoliosis As patients age,[pedclerk.bsd.uchicago.edu] […] hypoplasia, hyperconvex uplifted nails, multiple pigmented nevi, characteristic facies, short 4th metacarpal, high arched palate, or chronic otitis media.” 24 PWS is a rare[cmecorner.com] transverse palmar crease Highly arched eyebrow Hirsutism Poor speech Wide intermamillary distance Gait ataxia Areflexia Broad hallux Broad forehead Tics Intellectual disability[mendelian.co]

  • Absent Thumb - Short Stature - Immunodeficiency Syndrome

    spaced nipples, and webbed neck?[stuvia.com] […] dysplasia Eczema Postaxial polydactyly Severe platyspondyly Hyperconvex fingernails Diaphyseal thickening Subcortical cerebral atrophy Abnormal palate morphology Abnormality[mendelian.co] transverse palmar crease -Complete atrioventricular canal VSD ASD -Duodenal atresai, hirschsprung disease -earlyonset AD -Hypothyroidism, DMI -Atlantoaxial instability CAH[quizlet.com]

  • Microphthalmia Syndromic 6

    spaced nipples.[rarediseases.org] Finger and toe nails were hyperconvex. Thorax and lombo-sacral radiographies revealed no abnormalities.[molecularcytogenetics.biomedcentral.com] transverse palmar crease ; Small scrotum ; Small sella turcica ; Toe syndactyly ; Uplifted earlobe ; Ventriculomegaly Associated Genes BMP4 (Withdrawn symbols: BMP2B ) Mouse[mousephenotype.org]

  • Congenital Mandibular Hypoplasia

    spaced nipples - cubitus valgus - hyperconvex finger nails - short stature - sexual maturation failure (adrenarche normal, but delayed pubarche, and have premature menopause[quizlet.com] […] finger nails - short stature - sexual maturation failure (adrenarche normal, but delayed pubarche, and have premature menopause (infertile by 2 yo) NORMAL INTELLIGENCE Other[quizlet.com] transverse palmar crease - Pelvic dysplasia Other feats: Craniofacial - brachycephaly, flat occiput, prominent epicanthal folds, speckled irises (Brushfield spots), 3 fontanelles[quizlet.com]

  • Non-Immune Hydrops Fetalis

    Broad chest and widely spaced nipples. 13. Short 4 th metacarpals/ metatarsals 14. Bone dysplasia with coarse tubular pattern. 15.[jalananil.tripod.com] palmar creases, rhizomelic shortening of the upper extremities, slight ankle varus deformity bilaterally and bilateral humeral fractures.[ncbi.nlm.nih.gov] Narrow hyperconvex or deep set nails. 16. Excessive pigmented naevi. 17. Distal A.T.D. angle. 18. Loose skin about neck in infancy Other anomalies :- 1.[jalananil.tripod.com]

  • Congenital Non-Neoplastic Nevus

    Q83.2 Extra nipples (supernumerary nipples) Q83.3 Supernumerary nipple Q83.3 Inverted nipples Q83.8 Small nipple (hypoplastic) Q83.8 Widely spaced nipples Q83.8 Monilethrix[cdc.gov] (major if third phalanx is missing) Q84.3 Enlarged or hypertrophic nails Q84.5 Pachyonychia Q84.5 Congenital clubnail, koilonychia, malformation of nail, not otherwise specified[cdc.gov] Q82.8 or Q84.8 Vaginal or hymenal tags Q82.8 or Q84.8 Single transverse palmar crease Q82.80 Anal tag Q82.81 Skin tag Q82.81 Unusual dermatoglyphics Q82.84 Absent nipple[cdc.gov]

  • Hidrotic Ectodermal Dysplasia

    The incisors and canine teeth were peg shaped and widely spaced [Figure - 1] . Palm, sole and nails were normal.[ijdvl.com] Skin Palmoplantar keratoderma with transgradiens Nails Dystrophy thickened, milky white early on, micronychia, hyperconvex, longitudinal striations, discolored, brittle, absent[cram.com] transverse palmar creases Bone pain Joint dislocation Oligodontia Excessive salivation Overbite Dermal atrophy Delayed puberty Conductive hearing impairment Macrotia Coma[mendelian.co]

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