Hyperextensible Joints: Causes & Reasons

Possible Causes for Hyperextensible Joints

The facial appearance and some of the features resemble the SHORT syndrome, the name being an acronym for Short stature, Hyperextensible joints, Ocular depression, Rieger [ncbi.nlm.nih.gov]

The name is a mneumonic for the common features observed in SHORT syndrome that include; short stature, hyperextensibility of joints, ocular depression, Rieger anomaly and [malacards.org]

This 9-year-old Italian boy was short of stature and had partial lipodystrophy, minor facial anomalies, mild hyperextensibility of joints, ocular depression, Rieger anomaly [ncbi.nlm.nih.gov]

Hyper-IgE Syndrome

Nonimmunologic manifestations of HIES include a characteristic face, pathologic dentition, scoliosis, bone alterations, hyperextensible joints, and vascular abnormalities. [ncbi.nlm.nih.gov]

Common findings among patients were recurrent fractures (in 57 percent of patients), hyperextensible joints (in 68 percent), and scoliosis (in 76 percent of patients 16 years [scienceopen.com]

Our patient had hyperextensible joints including talipes cavus. [journals.lww.com]

Ehlers-Danlos Syndrome

joint hypermobility and skin fragility to the exceedingly critical consequences of arterial rupture and visceral perforation. [ncbi.nlm.nih.gov]

Ehlers-Danlos syndrome (EDS) is a rare hereditary disorder that results in skin hyperextensibility, joint hypermobility, and tissue fragility. [medcomic.com]

[…] finger hyperextension that occurs with pushing off of a wall with the palms of the hands). [8] Advise patients to minimize joint trauma by avoiding joint hyperextension or [emedicine.medscape.com]

Ehlers-Danlos Syndrome Classic-Like Type 1

Skin laxity, joint hyperextensibility, and bruisability are variable. [emedicine.medscape.com]

Soft, hyperextensible skin; joint hypermobility; bruising; normal scar formation Dominant (rare recessives) COL5A1 and COL5A2 Classical EDS Hypermobility Type (EDS type III [uwcpdx.org]

[…] skin, hypermobile joints and tissue fragility. [medical-dictionary.thefreedictionary.com]

3M Syndrome

Then, during childhood tall vertebral bodies, hip dislocation, transverse chest groove, winged scapulae and hyperextensible joints became more evident and the diagnosis of [ijponline.biomedcentral.com]

of the joints. [healthetreatment.com]

Joint hypermobility and soft, doughy and hyperextensible skin are some of the most striking characteristics in our patients. [mdpi.com]

Pseudoachondroplasia

Shortened Limbs Short stubby fingers Waddling walk Joint pain (with age) Large range of joint movement (hyperextensibility) in hands, knees and ankles Limited range of motion [littlepeopleuk.org]

an unusually large range of joint movement (hyperextensibility) in the hands, knees, and ankles; and a limited range of motion at the elbows and hips. [lilliputiae.com]

Other characteristic features of pseudoachondroplasia include short arms and legs; a waddling walk; joint pain in childhood that progresses to a joint disease known as osteoarthritis [encyclopedia.pub]

Osteoporosis-Pseudoglioma Syndrome

She had deformity of left lower limb, anterior bowing of both tibia, lax skin, hyperextensible joints. [ncbi.nlm.nih.gov]

[…] with mutations in LRP5 gene ( low density lipoprotein receptor-related protein-5) Clinical-manifestations short stature osteoporosis spontaneous fractures kyphoscoliosis hyperextensible [anvita.info]

She had deformity of left lower limb, anterior bowing of both tibia [Figure 1]B, lax skin, and hyperextensible joints. [pediatricneurosciences.com]

Marfan Syndrome

Potentially important abnormalities include hyperextensible joints (possible positioning implications), high arched palate (airway implications), pectus excavatum, and kyphoscoliosis [openanesthesia.org]

Joint hyperextensibility is present in some, but not all, patients with Marfan syndrome. [dermaamin.com]

Sternum deformity—pectus carinatum (outward displacement) or pectus excavatum (inward displacement)—is common, as are joint hyperextensibility (but usually small flexion contractures [msdmanuals.com]

Cartilage Hair Hypoplasia

Short limb dwarfism very fine thin light hairs and eyebrows hyperextensible joints of hand and feet abnormalities of spine neutropenia defective antibody and cell mediated [en.wikipedia.org]

Lateral Meningocele Syndrome

Other features of lateral meningocele syndrome can include low muscle tone (hypotonia) during infancy, decreased muscle bulk, loose (hyperextensible) joints that can lead [encyclopedia.pub]

Joint hypermobility Double-Jointed, Extensible joints, Increased mobility of joints, Flexible joints, Joint hyperextensibility, Hyperextensible joints [more] The ability of [rarediseases.oscar.ncsu.edu]

Mirhosseini-Holmes-Walton Syndrome

Clinical: Microcephaly; severe mental retardation; hyperextensible joints; scoliosis; arachnodactyly; hypogonadism. McKusick VA. [esanatos.com]

joints Head And Neck Teeth: prominent incisors Head And Neck Eyes: myopia decreased visual acuity retinal pigmentary degeneration Growth Weight: truncal obesity Growth Height [malacards.org]

joints, scoliosis, and arachnodactyly. [omim.org]

Langer-Giedion Syndrome

(scoliosis) Limbs Hyperextensible joints Prone to fractures Formation of new bone on the surface of a bone (exostoses of long bones) Hands Misshapen fingers Fused fingers [nfed.org]

joints. [rarediseases.org]

In addition, affected individuals may exhibit unusually flexible (hyperextensible) joints, diminished muscle tone (hypotonia), excess folds of skin (redundant skin), and/or [rarediseases.org]

MACS Syndrome

[…] skin, joint hypermobility, and scoliosis. [mendelian.co]

[…] skin, High pitched voice, Joint hypermobility, Muscular hypotonia, Prolonged bleeding time, Umbilical hernia, Sparse hair, Urethral stenosis, Thick lower lip vermilion, Sparse [fdna.health]

[…] alopecia, cutis laxa and scoliosis (MACS) syndrome, is a very rare inherited connective tissue disorder characterized by macrocephaly, sparse scalp hair, soft-redundant and hyperextensible [mendelian.co]

Coffin-Lowry Syndrome

joints, muscle atrophy, large and soft hands with simian crease, and tapering of the fingers. [accessanesthesiology.mhmedical.com]

Males present with moderate to severe developmental delay, coarse facies, large soft hands with short tapering fingers, hypotonia, joint hyperextensibility and skeletal changes [ggc.org]

[…] musculoskeletal system presents as short thorax, bifid sternum, pectus excavatum or carinatum, vertebral dysplasia, kyphosis, scoliosis, delayed bone age, ligamental calcifications, hyperextensible [accessanesthesiology.mhmedical.com]

Rubinstein-Taybi Syndrome

Hyperextensible joints were noted. The patient’s thumbs were broad with recently corrected radial angulation. [faoj.org]

joints Small tilted pelvis Excessive hairiness Undescended testicles Feeding difficulties Respiratory infection Cardiac anomalies Vertebral abnormalities Gastroesophageal [aapos.org]

joints, and keloid formation. [faoj.org]

Mucopolysaccharidosis

It is marked by shortness and hyperextension of the neck causing the head to appear as if it were resting directly on the shoulders, short trunk, long extremities with excessive [icd9data.com]

[…] of neck hyperextension [32]. [hindawi.com]

Careful positioning and avoidance of hyperextension of the neck are necessary. [medicalhomeportal.org]

Mucopolysaccharidosis Type 4A

[…] atlantoaxial joint, requiring limited hyperextension of the neck all of which may complicate laryngoscopy and intubation [ 3 ]. [omicsonline.org]

It is marked by shortness and hyperextension of the neck causing the head to appear as if it were resting directly on the shoulders, short trunk, long extremities with excessive [icd10data.com]

Patients present with severe airway obstructions, cranio-facial abnormalities, short neck, stiffening of the temporomandibular joints, anteriorly positioned larynx, unstable [omicsonline.org]

Trisomy 21

hyperextensibility or hyperflexibility Neuromuscular hypotonia Diastasis recti Dry skin Premature aging Congenital heart defects Complications of Down syndrome can involve [emedicine.com]

[…] extremities Short, broad hands, with short fifth finger with hypoplasia of the middle phalanx and clinodactyly, along with single transverse palmar creases (~60% of patients) Joint [emedicine.com]

Stickler Syndrome Type 2

joints * Clubfeet * Prominent large joints * Severe joint disease * Joint pain * Partial dislocation of hip * Spondyloepiphyseal dysplasia * Flat vertebrae * Underdevelopment [checkorphan.org]

joints and arthritis ... [ibis-birthdefects.org]

[…] and fragility, joint hypermobility, and abnormal wound healing. [chginc.org]

De Barsey-Moens-Dierckx Syndrome

joints, increased tendon reflexes and growth retardation already beginning in the womb combined with reduced mental development. [de.zxc.wiki]

Findings from examination disclosed a variety of dysmorphic features, including cutis laxa, progeroid aspect, short stature, multiple hyperextensible subluxated joints, muscular [jamanetwork.com]

Generalized joint hyperextensibility and severe osteoporosis usually are present. Intelligence is normal. Presentation with hypotonia in childhood is possible. [accessanesthesiology.mhmedical.com]

Bannayan-Riley-Ruvalcaba Syndrome

hyperextensibility Women with this syndrome have a higher risk of breast cancer. [radiopaedia.org]

It is unclear if the case-based signs of myopathic processes in proximal muscles, pectus excavatum, joint hyperextensibility, scoliosis and high birth weight are truly components [orpha.net]

Skeletal abnormalities have also been described with this condition, including an unusually large range of joint movement (hyperextensibility), abnormal side-to-side curvature [encyclopedia.pub]

Autosomal Recessive Cutis Laxa Type 2B

Individuals with these conditions often present with cutis laxa, progeroid features, and hyperextensible joints. [mdpi.com]

Hyperextensibility of joints + + + + + +/− +/− + + + + + − Dislocations − − + - − + − − − − − Adducted thumbs − − + + + + + − + − − − Clenched hands − − + + − − + − + − − [mdpi.com]

Overlapping Features Cutis laxa, progeroid features, hyperextensible joints, inelastic wrinkled skin, and flat feet are features found in all three cutis laxa syndromes (Figure [mdpi.com]

Hallermann-Streiff Syndrome

Patients present with proportionate small stature, scoliosis and hyperextensible joints. [ai-online.info]

[…] of the joints. [healio.com]

[…] hypotrichosis of scalp, eyebrows and eyelashes, microphthalmia, congenital cataracts, blue sclera, nystagmus, mandibular hypoplasia, forward displacement of temporomandibular joints [ai-online.info]

Vesicoureteral Reflux 8

Involvement in disease Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and [abcam.com]

TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. [david.ncifcrf.gov]

Osteogenesis Imperfecta Type 15

(hyperextensible) Blue sclera Triangular face Spinal curvature Teeth possibly brittle (dentinogenesis imperfecta) Hearing loss in 20s or 30s Type II Most severe form Usually [en.wikibooks.org]

Associated features may include blue sclerae, dentinogenesis imperfecta, hearing impairment, progressive deformity of long bones and/or spine, and joint hyperextensibility [journals.plos.org]

Additional symptoms associated with osteogenesis imperfecta type I include loose (hyperextensible) joints, low muscle tone (hypotonia), and thin skin that bruises easily. [healthjade.net]

Ehlers-Danlos Syndrome Type 4

Soft, hyperextensible skin; joint hypermobility; bruising; normal scar formation Dominant (rare recessives) COL5A1 and COL5A2 Classical EDS Hypermobility Type (EDS type III [uwcpdx.org]

They are generally characterized by joint hypermobility (joints that stretch further than normal), skin hyperextensibility (skin that can be stretched further than normal) [ehlers-danlos.com]

Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability. [icd10data.com]

Aarskog-Scott Syndrome

Findings on the extremities include joint hyperextensibility, short and broad hands, interdigital webbing, a short fifth finger, clinodactyly and broad feet with bulbous toes [ncbi.nlm.nih.gov]

Other findings include cryptorchidism, proximal finger-joint hyperextensibility, flexed distal finger joints, stretchable skin, shawl and/or saddle-bag scrotum, widow’s peak [medical-dictionary.thefreedictionary.com]

Secondary criteria include: abnormal auricles with fleshy lobules, posteriorly angulated ears, widow's peak, ptosis, downward slant of palpebral fissures, joint hyperextensibility [ncbi.nlm.nih.gov]

Hypochondroplasia

Abstract Mutations in the tyrosine kinase domain of fibroblast growth factor receptor gene (FGFR3) have been described in some cases of hypochondroplasia (Hch). We screened 65 children with Hch diagnosed by clinical and radiologic criteria for 2 previously described mutations, C1620A and C1620C in FGFR3; 28 (43%)[…] [ncbi.nlm.nih.gov]

Ehlers-Danlos Syndrom Classic Type 2

Abstract The type II (mitis) variant of Ehlers-Danlos syndrome (EDS) is an autosomal dominant disorder characterized by mild skin hyperextensibility, mild joint hypermobility [mdedge.com]

[…] skin, abnormal scarring, easy bruising, hyperextensible joints and generalized periodontitis Resembles type I, but is distinguished by early loss of teeth and characteristic [en.wikibooks.org]

Soft, hyperextensible skin; joint hypermobility; bruising; normal scar formation Dominant (rare recessives) COL5A1 and COL5A2 Classical EDS Hypermobility Type (EDS type III [uwcpdx.org]

Ehlers-Danlos Syndrome Hypermobility Type

Individuals with Hypermobile EDS classically present with hyperextensible joints and skin. [3pointproducts.com]

Individuals of hypermobility joint syndrome often present with hyperextensible joints, chronic back pain, joint pain, among other phenotypic changes. [acrabstracts.org]

Soft, hyperextensible skin; joint hypermobility; bruising; normal scar formation Dominant (rare recessives) COL5A1 and COL5A2 Classical EDS Hypermobility Type (EDS type III [uwcpdx.org]