Hyperglobulinemia: Causes & Reasons

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Possible Causes for Hyperglobulinemia

Hyperglobulinemic Purpura

[…] occurring in old people, characterized by proliferation of cells resembling lymphocytes or plasma cells in the bone marrow, anemia, an increased sedimentation rate, and hyperglobulinemia [medical-dictionary.thefreedictionary.com]

Humerfelt, S.: Purpura with Hyperglobulinemia, Nord. med. 34:1101, 1947. 8. Kay, H. E. M., and Robertson, K. M.: Benign Hyperglobulinaemic Purpura, J. [deepdyve.com]

Three cases of purpura hyperglobulinemia are reported with emphasis on the patients' protein abnormalities. [jamanetwork.com]

Idiopathic Cryoglobulinemia

[…] polymorphonuclear neutrophils ( D71 ) human immunodeficiency virus [HIV] disease ( B20 ) D89 Other disorders involving the immune mechanism, not elsewhere classified Excludes1 hyperglobulinemia [icd10coded.com]

ICD-10-CM Diagnosis Code D89 Other disorders involving the immune mechanism, not elsewhere classified 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes hyperglobulinemia [icd10data.com]

Visceral Larva Migrans

Eosinophilia, leukocytosis and hyperglobulinemia were the most frequent laboratory findings. [ncbi.nlm.nih.gov]

The major host responses to these antigens include a marked eosinophilia and hyperglobulinemia. [ncbi.nlm.nih.gov]

Common clinical manifestations are marked eosinophilia and hyperglobulinemia, caused by the host immune response to the larval helminths [ 1 ]. [jmedicalcasereports.biomedcentral.com]

Waldenstrom Macroglobulinemia

Bing J et al. (1937) Reports of a third case of hyperglobulinemia with affection of the central nervous system on a toxi-infectious basis. [doi.org]

Incipient myelomatosis or ‘essential’ hyperglobulinemia with fibrinogenopenia a new syndrome?. Acta Med Scand, CXVII (1944), pp. 217-246 [4] R.E. Cooke, R.M. [revistagastroenterologiamexico.org]

Waldenström J: Incipient myelomatosis or “essential” hyperglobulinemia with fibrinogenopenia: a new syndrome ? Acta Med Scand 1944, 117 :216–222. [doi.org]

Hyperviscosity Syndrome

Hyperglobulinemia of multiple myeloma (MM) plays a role in hyperviscosity syndrome (HVS). [ncbi.nlm.nih.gov]

Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia: A new syndrome? Acta Med Scand. 1944;! 17:216-247. 2. Bloch KJ, Maki DG. [healio.com]

Heavy Chain Disease

[…] hypermutation: implications for oncogene translocations and heavy chain disease. ( 9482908 ) Goossens T....KA1ppers R. 1998 45 A case of mu heavy-chain disease associated with hyperglobulinemia [malacards.org]

: A case of mu heavy-chain disease associated with hyperglobulinemia, anemia, and a positive Coombs test. Ann Hematol 1998, 77:231–234. [link.springer.com]

Castleman Disease

The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy. [ncbi.nlm.nih.gov]

[…] most common of these are anemia, fever, diaphoresis, weight loss, night sweating and fatigue. 1,2,9 Patients with M-PCV may have an elevated erythrocyte sedimentation rate, hyperglobulinemia [scielo.br]

View Article PubMed Google Scholar Neerhout RC, Larson W, Mansur P: Mesenteric lymphoid hamartoma associated with hypoferremia, anaemia, growth failure and hyperglobulinemia [wjso.com]

Chronic Active Hepatitis B

[…] authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal hyperglobulinemia [hepatitiscentral.com]

Non-Hodgkin Lymphoma

It is characterized by hyperglobulinemia, excess bence-jones proteins (free monoclonal immunoglobulin light chains) in the urine, skeletal destruction, bone pain, and fractures [icd9data.com]

Massive Hepatic Necrosis

Criteria for Diagnosis: liver biopsy or at least three of the following: Hyperglobulinemia, esp. with hypoalbuminemia Low protein ( 32. [slideshare.net]

Cryoglobulinemia

Macronodular Cirrhosis

Significance of hyperglobulinemia in severe chronic liver diseases--with special reference to the correlation between serum globulin/IgG level and ICG clearance. [ncbi.nlm.nih.gov]

Visceral Leishmaniasis

In active VL, macrophages host the replicating amastigotes in phagolysosomal compartments leading to splenomegaly, hepatomegaly, hyperglobulinemia, anemia, weight-loss, incessant [books.google.com]

Marked hyperglobulinemia with no apparent cause in dogs from Leishmania -endemic regions should suggest possible canine leishmaniosis. [msdvetmanual.com]

Serum biochemistry revealed hyperproteinemia 100.0 g/L [54.0 – 82.0 g/L], hyperglobulinemia 83.0 g/L [23.0 – 52.0 g/L] and hypoalbuminemia 18.0 g/L [25.0 – 44.0 g/L]. [parasitesandvectors.biomedcentral.com]

Multiple Myeloma

It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures [definitions.net]

Angioimmunoblastic Lymphadenopathy

In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%). [emedicine.medscape.com]

De Quervain Thyroiditis

Other tests that may prove helpful diagnostically In patients with subacute thyroiditis, mild anaemia and hyperglobulinemia may be present. [endocrinologyadvisor.com]

Immune Thrombocytopenic Purpura

It should be noted that many hematological diseases have oral manifestations like ITP: aplastic anemia, Glanzman thrombasthenia, Hemophilias, Ehlers Danlos Syndrome, Hyperglobulinemia [benthamopen.com]

Systemic Lupus Erythematosus

[…] neck, or upper extremities, with liquefaction degeneration of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia [medical-dictionary.thefreedictionary.com]

[…] resembling rheumatoid arthritis; diffuse erythematous skin lesions on the face, neck, or upper extremities; lymphadenopathy; pleurisy or pericarditis; glomerular lesions; anemia; hyperglobulinemia [medical-dictionary.thefreedictionary.com]

Sjögren Syndrome

Hyperglobulinemia may lead to the formation of immune complexes with the potential to precipitate in major organs leading to (irreversible) damage [30]. [medsci.org]

Polycythemia Vera

[…] hematopoietic stem cells, characterized by increased blood volume, bone marrow hyperplasia, redness of the skin, and splenic enlargement. polycythemia vera polycythemia vera Hyperglobulinemia [medical-dictionary.thefreedictionary.com]

Third Trimester Pregnancy

OBJECTIVES: A proper implantation of trophoblastic cells and an appropriate metalloproteinases activity is required to cause disintegration of basal membranes of cells. The activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - TIMP-s. Survivin is a member of inhibitor of apoptosis[…] [ncbi.nlm.nih.gov]

Female Pelvic Inflammatory Disease

Sexually Transmitted Diseases: Article Trends in Pelvic Inflammatory Disease Hospital Discharges and Ambulatory Visits, United States, 1985–2001 Sutton, Madeline Y. MD, MPH; Sternberg, Maya PhD; Zaidi, Akbar PhD; St. Louis, Michael E. MD; Markowitz, Lauri E. MD Author Information From the Division of Sexually Transmitted[…] [web.archive.org]

Toxoplasmosis

Toxoplasmosis is an infectious disease caused by the protozoan Toxoplasma gondii. In an immunocompetent host, infection is generally asymptomatic, but toxoplasmosis in pregnancy can cause birth defects. Asymptomatic lymphadenopathy is the most usual presentation. The main lymph nodes involved are cervical and[…] [symptoma.com]

Diabetes Mellitus

Patients with type 1 diabetes mellitus usually present with classic acute symptoms of hyperglycemia. These include: Polyuria (due to osmotic diuresis when blood glucose level exceeds renal threshold) Thirst (as a consequence of loss of fluids and electrolytes by osmotic diuresis) Postural hypotension (due to[…] [symptoma.com]

Infectious Mononucleosis

Infectious mononucleosis is usually a self-limiting illness, but can be rarely associated with complications. A 17-year-old boy with Epstein-Barr virus related infectious mononucleosis and cold antibody-mediated autoimmune hemolytic anemia with incidentally noted multiple pulmonary nodules. Nodules regressed over the next[…] [ncbi.nlm.nih.gov]

Subcutaneous Abscess

Extraintestinal infestation by Enterobius vermicularis is uncommon. It has been reported to occur in the peritoneal cavity, ovary, fallopian tube, endometrium, lung, liver and urinary tract. Fine needle aspiration diagnosis was made in a case of enterobiasis presenting with a subcutaneous abscess in the natal cleft.[…] [ncbi.nlm.nih.gov]

Hashimoto Thyroiditis

History Hypothyroidism is usually insidious in onset, with signs and symptoms slowly progressing over months to years. Most commonly, patients do not relate a history suggestive of transient hyperthyroidism secondary to increased T4 and T3 levels resulting from thyrocyte destruction. The time course is influenced[…] [emedicine.medscape.com]

Chronic Bronchitis

Carbohydrate antigen 19-9 (CA19-9) is the most frequently applied serum tumor marker for diagnosis of cancers in the digestive organs. However, some patients with benign diseases can have elevated serum levels of CA19-9 as well. The current study presents a 55-year-old female who was admitted to our hospital for[…] [ncbi.nlm.nih.gov]

Adenocarcinoma of the Prostate

Virchows Arch. 2013 Apr;462(4):429-36. doi: 10.1007/s00428-013-1385-5. Epub 2013 Feb 27. Abstract Ductal adenocarcinoma (DAC) of the prostate is thought to have worse prognosis than prostatic acinar carcinoma (PAC). We aimed to evaluate the prognostic significance of histopathological patterns of DAC. A series of[…] [ncbi.nlm.nih.gov]

Polymyalgia Rheumatica

Polymyalgia rheumatica In polmyalgia rheumatica, pain is usually located in the shoulders and hips. Specialty Rheumatology Polymyalgia rheumatica (PMR) is a syndrome with pain or stiffness, usually in the neck, shoulders, upper arms, and hips, but which may occur all over the body. The pain can be very sudden, or can[…] [en.wikipedia.org]