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54 Possible Causes for Hyperglobulinemia, Lymph Node Hyperplasia

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] node hyperplasia, is a rare disorder of the lymphoid tissue that causes lymph node enlargement.[scielo.br] Castleman's disease (CD) is a rare lymphoproliferative disease characterized by angiofollicular lymph node hyperplasia.[ncbi.nlm.nih.gov]

  • Heavy Chain Disease

    […] hypermutation: implications for oncogene translocations and heavy chain disease. ( 9482908 ) Goossens T....KA1ppers R. 1998 45 A case of mu heavy-chain disease associated with hyperglobulinemia[malacards.org] Okuda K, Himeno Y, Ioyama I, Ohta M, Kitagawa M, Sugai S (1982) Gamma heavy chain disease and giant lymph node hyperplasia in a patient with impaired T call function.[link.springer.com] . : A case of mu heavy-chain disease associated with hyperglobulinemia, anemia, and a positive Coombs test. Ann Hematol 1998, 77:231–234.[link.springer.com]

  • Rosai-Dorfman Disease

    Although the histopathology is fairly distinctive, the laboratory abnormalities are not; past reports note elevated erythrocyte sedimentation rate, anemia, and polyclonal hyperglobulinemia[ncbi.nlm.nih.gov] There were 8 hilar lymph nodes measuring 4–8 mm in diameter. All were diagnosed as reactive hyperplasia. Fig. 2.[rc.rcjournal.com] The typical clinical features of this disease include bilateral painless lymphadenopathy, fever, and polyclonal hyperglobulinemia.[jdrntruhs.org]

  • Lymphoproliferative Syndrome 1

    ICD-10-CM Diagnosis Code D89 Other disorders involving the immune mechanism, not elsewhere classified 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes hyperglobulinemia[icd10data.com] Lymph nodes showed marked paracortical hyperplasia.[thedoctorsdoctor.com] Histopathological analysis of lymph nodes showed lymphadenitis with paracortical hyperplasia.[casereports.bmj.com]

  • Ankylosing Spondylitis

    node syndrome (also known as mucocutaneous lymph node syndrome and Kawasaki disease) Lymphoid hamartoma (also known as angiofollicular lymph node hyperplasia, Castleman’s[skbthrive.wordpress.com] node hyperplasia (Castleman’s disease, giant lymph node hyperplasia, lymphoid hamartoma) Ankylosing spondylitis (AS, Bekhterev’s disease, Marie-Strümpell disease) Anti-GBM[autoimmunecoach.co.uk] node hyperplasia (also known as Castleman’s disease, giant lymph node hyperplasia, and lymphoid hamartoma) Ankylosing spondylitis (AS; also known as Bekhterev’s disease and[skbthrive.wordpress.com]

  • Alpha-Heavy Chain Disease

    . : A case of mu heavy-chain disease associated with hyperglobulinemia, anemia, and a positive Coombs test. Ann Hematol 1998, 77:231–234.[link.springer.com] Okuda K, Himeno Y, Ioyama I, Ohta M, Kitagawa M, Sugai S (1982) Gamma heavy chain disease and giant lymph node hyperplasia in a patient with impaired T call function.[link.springer.com] The mesenteric lymph nodes, which showed reactive hyperplasia in the first biopsy, transformed later to a malignant lymphoma and finally to a plasma cell tumour.[ncbi.nlm.nih.gov]

  • Measles

    Measles, a vaccine-preventable illness, is one of the most infectious diseases known to man. In 2015, an estimated 134,200 measles deaths occurred globally. Rubella, also vaccine-preventable, is a concern because infection during pregnancy can result in congenital defects in the baby. More than 100,000 babies with[…][ncbi.nlm.nih.gov]

  • Sarcoidosis

    Computed tomography revealed mediastinal and hilar lymph node hyperplasia.[ncbi.nlm.nih.gov]

  • Systemic Amyloidosis

    Biopsy of the submandibular mass revealed angiofollicular lymph node hyperplasia consistent with a diagnosis of Castleman's disease.[karger.com] First is Castleman disease, also known as angiofollicular lymph node hyperplasia. 38 Extensive involvement of the AA amyloid can occur, even with unicentric Castleman disease[bloodjournal.org] Keller AR, Hochholzer L, Castleman B: Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations.[karger.com]

  • Polyclonal Hypergammaglobulinemia

    Official Long Descriptor Polyclonal hypergammaglobulinemia Benign hypergammaglobulinemic purpura Polyclonal gammopathy NOS D89 Excludes1: hyperglobulinemia NOS ( R77.1 ) monoclonal[coder.aapc.com] Continuous 1L-6 stimulation in mice produces hypergammaglobulinemia and mimics the chronic B cell hyperplasia of Castleman's disease, or giant lymph node hyperplasia.[arthritisresearch.us] […] polymorphonuclear neutrophils ( D71 ) • human immunodeficiency virus [HIV] disease ( B20 ) D89 Other disorders involving the immune mechanism, not elsewhere classified Excludes: • hyperglobulinemia[coding-pro.com]

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