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33 Possible Causes for Hyperglobulinemia, Progressive Loss of Vision, Retinal Detachment

  • Toxoplasmosis

    […] neuritis [19] Scleritis [36,39] Retinal detachment [68] Punctate outer retinitis [29,31,34] Branch retinal artery occlusion [69]; Frosted branch angiitis Coats’-type response[] If the central structures of the retina are involved there will be a progressive loss of vision that can lead to blindness.[] Eye pain Sensitivity to light (photophobia) Tearing of the eyes Blurred vision The eye disease can reactivate months or years later, each time causing more damage to the retina[]

  • Hyperviscosity Syndrome

    (PED) beneath the serous retinal detachment.[] Hyperglobulinemia of multiple myeloma (MM) plays a role in hyperviscosity syndrome (HVS).[] Neurologic symptoms of hyperviscosity include blurring or loss of vision, headache, vertigo, sudden deafness, diplopia, ataxia, confusion, and disturbances of consciousness[]

  • Diabetes Mellitus

    Spontaneous bleeding from the new and brittle blood vessels can lead to retinal scarring and retinal detachment, thus impairing vision.[] It is caused by small blood vessel damage to the back layer of the eye, the retina, leading to progressive loss of vision, even blindness.[] There are no early symptoms or signs, but focal blurring, vitreous or retinal detachment, and partial or total vision loss eventually develop; rate of progression is highly[]

  • Waldenstrom Macroglobulinemia

    Bing J et al. (1937) Reports of a third case of hyperglobulinemia with affection of the central nervous system on a toxi-infectious basis.[] A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom.[] […] changes, such as blurred vision or blind spots Weight loss for no reason Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Peripheral blood smear Progression[]

  • Central Retinal Vein Occlusion

    […] after complicated retinal detachment surgery.[] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[] […] worsening, painless, monocular vision loss. 1,4 Evaluation and Treatment: Obtain visual acuity (vision often significantly reduced in the affected eye ( 20/200)). 2,3 Perform[]

  • Systemic Lupus Erythematosus

    […] neck, or upper extremities, with liquefaction degeneration of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia[] Because of the choroidal effusion, retinal detachment and secondary angle-closure glaucoma may occur.[] Optic neuropathy is a rare ophthalmological complication of SLE that can progress to total bilateral vision loss if not identified and treated rapidly.[]

  • Renal Cell Carcinoma

    Here we present a grade 4 panuveitis with bilateral serous retinal detachment following treatment with nivolumab for metastatic renal cell carcinoma.[] As the disease progresses, symptoms may include: a lump in the abdomen blood in the urine unexplained weight loss loss of appetite fatigue vision problems persistent pain[] detachment.[]

  • Syphilis

    We present a case of a 33-year-old man with recently identified syphilis and HIV, who was diagnosed with bilateral retinal detachments (RDs) with the help of point-of-care[] Abstract We present a case of ocular syphilis after a renal transplantation involving progressive vision loss without clinically identifiable ocular disease.[] Initial symptoms may include headache, neck stiffness, dizziness, behavioral abnormalities, poor concentration, memory loss, lassitude, insomnia, and blurred vision.[]

  • Visceral Larva Migrans

    Conclusion:Inflammation created in response to Toxocara larvae may lead to traction retinal detachment of the macula.[] Eosinophilia, leukocytosis and hyperglobulinemia were the most frequent laboratory findings.[] Eye infections caused by numerous migrating larvae of Toxocara parasites, probably due to re-invasion or delayed reactivation, and leading to a progressive loss of vision[]

  • Behçet Disease

    Some ocular manifestations like glaucoma, cataract and retinal detachment may require surgical intervention.[] In contrast to idiopathic cases, OPN in BD is more likely to demonstrate initial rapid progression of visual loss and more severe loss at presentation.[] Eye involvement - eg, glaucoma, cataracts or retinal detachment. CNS aneurysms or clots.[]

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