Hypergranulosis: Causes & Reasons

Possible Causes for Hypergranulosis

Congenital Non-Bullous Ichthyosiform Erythroderma ARCI 10

Ichthyosis Very Common - Between 80% and 100% cases Palmoplantar keratoderma Very Common - Between 80% and 100% cases Short stature Uncommon - Between 30% and 50% cases Hypergranulosis [mendelian.co]

[…] examination of the collodion membrane showed nonspecific findings typical of many forms of ichthyosis: a thickened stratum corneum with hyperkeratosis, acanthosis, and mild hypergranulosis [bio2rdf.org]

Palmoplantar Keratosis

—There is epidermal hyperplasia with hypergranulosis, a thin layer of parakeratosis, and overlying orthokeratosis. [dermatology.cdlib.org]

Electron microscopy showed hyperorthokeratosis with hypergranulosis and loss of lamellar structure of the keratinosomes, as well as cleavage between corneocytes. [okina.univ-angers.fr]

Histopathologic examination revealed orthohyperkeratosis within focal clavus‐like depressions of the epidermis and prominent hypergranulosis. [www3.interscience.wiley.com]

Diffuse Palmoplantar Keratoderma

Histopathological examination of the skin biopsy taken from the patient’s sole revealed orthokeratotic hyperkeratosis, hypergranulosis and acanthosis without epidermolysis [indianpediatrics.net]

Electron microscopy showed hyperorthokeratosis with hypergranulosis and loss of lamellar structure of the keratinosomes, as well as cleavage between corneocytes. [okina.univ-angers.fr]

and acanthosis (PPK) Birth-Adolescence Yes No H H Compact hyperkeratotsis, hypergranulosis, and acanthosis, subepidermal vessels were dilated, mild mononuclear cell infiltrate [dermatologyadvisor.com]

Verruca Vulgaris

Hypergranulosis (thicker stratum granulosum). Papillomatous hyperplasia : Rete ridge lengthening (~7-10x normal) and thickening. [librepathology.org]

Hypergranulosis (thicker stratum granulosum). Papillomatous hyperplasia: Rete ridge lengthening (~7-10x normal) and thickening. [librepathology.org]

[…] types 2 and 4; the lesions are of variable duration, eventually undergoing spontaneous regression, and are both exophytic and endophytic, with hyperkeratosis, parakeratosis, hypergranulosis [medical-dictionary.thefreedictionary.com]

Hypertrophic Lichen Planus

Although these changes bear some similarities to those in erythema multiforme, lichen planus shows well-developed changes of chronicity, including epidermal hyperplasia, hypergranulosis [doctoralerts.com]

Whickham striae are usually seen in the areas of hypergranulosis [1]. [hindawi.com]

Features specific to LP cases were compact orthokeratotic hyperkeratosis, wedge-shaped hypergranulosis, and saw-toothed epidermal hyperplasia. [ijdpdd.com]

Bullous Lichen Planus

Biopsy from the edge of the lesion showed hypergranulosis, hydropic degeneration of the basal cell layer and a bandlike infiltrate composed of mainly lymphocytes in the papillary [escholarship.org]

Histologic Features A hyperkeratotic cornified layer Hypergranulosis Irregular epidermal hyperplasia Vacuolar alterations of the basal layer A subepidermal blister with a [dxpath.com]

Epidermodysplasia Verruciformis

The histopathologic features of EV consist of papillated epidermal hyperplasia with hypergranulosis and a distinct bluish-gray color in the large human papillomavirus-infected [ncbi.nlm.nih.gov]

Areas of epidermis showed compact orthokeratosis, coarse hypergranulosis, and keratinocytes with abundant steel-blue-gray cytoplasm, indicative of viral cytopathic changes [ncbi.nlm.nih.gov]

Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. [ncbi.nlm.nih.gov]

Pityriasis Rubra Pilaris

Occasionally, mild spongiosis with scattered intraepidermal lymphocytes In early lesions, parakeratosis is poorly developed and lamellar ortho hyperkeratosis predominates; hypergranulosis [pathologyoutlines.com]

[…] histologic) description Biopsy from non-follicular lesion consists of alternating orthokeratosis and parakeratosis in both vertical and horizontal directions Focal or confluent hypergranulosis [pathologyoutlines.com]

Lichen Simplex Chronicus

As a consequence, there are compact orthokeratosis, hypergranulosis, uneven psoriasiform acanthosis, and coarse bundles of collagen arranged in vertical streaks in a thickened [derm101.com]

Histologically, the lesions were characterized by moderate to marked hyperorthokeratosis and wedge-shaped hypergranulosis. [ncbi.nlm.nih.gov]

Histopathology of HLP, PN and LSC demonstrates epidermal hyperplasia, compact hyperkeratosis and hypergranulosis. [omicsonline.org]

Hereditary Koilonychia

On histopathological examination with hematoxylin and eosin stain hyperkeratosis with parakeratosis, hypergranulosis, and papillamatous acanthosis were noted [Figure 8]. [jdrntruhs.org]

Histopathology of palmar skin showed lining of stratified squamous epithelium with hyperkeratosis, hypergranulosis, and acanthosis. [e-ijd.org]

[…] osteopenia Click here to view Figure 7: X-rays of skull showing prognathism, forward protrusion of the mandible Click here to view Figure 8: Hyperkeratosis with parakeratosis, hypergranulosis [jdrntruhs.org]

Papillon Lefevre Disease

Skin biopsy shows hyperkeratosis with focal parakeratosis, moderate perivascular infiltration, hypergranulosis, and acanthosis. [rarediseases.info.nih.gov]

Lichen Planus

They differ from those of cutaneous disease in several respects, including the presence of parakeratosis, epithelial atrophy, and lack of hypergranulosis. [ncbi.nlm.nih.gov]

LP has an associated set of characteristic histopathologic findings which include hyperkeratosis, vacuolization of the basal layer, Civatte bodies, wedge-shaped hypergranulosis [ncbi.nlm.nih.gov]

Whickham striae are usually seen in the areas of hypergranulosis [ 1 ]. [hindawi.com]

Congenital Ichthyosiform Erythroderma

Although the stratum corneum of patients with LI was two to three times thicker than that of those with CIE, the latter group demonstrated more acanthosis, parakeratosis, hypergranulosis [ncbi.nlm.nih.gov]

On day 25, the normal cultures displayed an even more pronounced hyperkeratosis and hypergranulosis, whereas the reconstructed epidermis of pathological origin presented a [ncbi.nlm.nih.gov]

A biopsy of abdominal skin revealed acanthosis with hypergranulosis and homogeneously thickened stratum corneum. [medicaljournals.se]

Prurigo Nodularis

There was also hypergranulosis, marked acanthosis, and irregular elongation of the rete ridges. These findings were consistent with prurigo nodularis. [ncbi.nlm.nih.gov]

[…] conjunction with a thick and compact cornified layer, like that of volar skin); irregular epidermal hyperplasia or pseudoepitheliomatous hyperplasia; focal parakeratosis; hypergranulosis [ncbi.nlm.nih.gov]

Histopathology revealed hyperkeratosis, orthokeratosis, focal hypergranulosis, and irregular acanthosis with foci of pseudoepithelomatous hyperplasia. [ncbi.nlm.nih.gov]

Keratosis Pilaris

Biopsy reveals: Epidermal hyperkeratosis Hypergranulosis Plugged hair follicles Mild superficial perivascular lymphocytic inflammation What is the treatment for keratosis [dermnetnz.org]

Major histologic and dermatoscopic findings of KP were hyperkeratosis, hypergranulosis, mild T helper cell type 1-dominant lymphocytic inflammation, plugging of follicular [ncbi.nlm.nih.gov]

Woolly Hair Nevus

Figure 3: Histopathology (Hematoxylene and Eosin stain, ×40 magnification) showing papillated epidermal hyperplasia, with hypergranulosis and hyperkeratosis composed of compact [e-ijd.org]

HPE Hyperkeratosis Acanthosis Hypergranulosis Inc Keratohyaline Granules perinuclear vacuolization of keratinocytes s/o EHK Few inflamm cells 13. [slideshare.net]

[…] woolly hair lying alongside a normal hair of a child of same age Click here to view Histopathology of skin lesion [Figure 3] revealed papillated epidermal hyperplasia, with hypergranulosis [e-ijd.org]

Palmoplantar Keratoderma of Sybert

—There is epidermal hyperplasia with hypergranulosis, a thin layer of parakeratosis, and overlying orthokeratosis. [escholarship.org]

There is orthokeratoderma, hypergranulosis, acanthosis and vacuolar alterations of the granular layers and superior part of the corneum stratum. [scielo.br]

Histopathological exam of the biopsy (Figures 4 and 5) collected from the plantar surface demonstrated intense compact orthokeratosis, hypergranulosis and acanthosis, together [scielo.br]

Large Cell Acanthoma

[…] epidermal keratinocytes) Usually well demarcated from adjacent epidermis Basal layer may appear hyperpigmented; sometimes conspicuous rete ridges Orthokeratosis; may have hypergranulosis [pathologyoutlines.com]

In terms of histology, all lesions were clearly delineated, with hypergranulosis beneath hyperorthokeratosis, occasionally with accentuation of the papillary outline. [pubmed.ncbi.nlm.nih.gov]

Acantholytic Acanthoma

[…] hyperkeratosis Focal incidental epidermolytic hyperkeratosis may be present Still classified as seborrheic keratosis if covering < 50% of the surface Verruca or condyloma: Hypergranulosis [pathologyoutlines.com]

Pilar Sheath Acanthoma

Progressive Palmoplantar Keratoderma of Greither

Histologic findings include hyperkeratosis, hypergranulosis, and acanthosis. [emedicine.medscape.com]

Histopathological findings Biopsy specimens revealed hyperkeratosis with areas of orthokeratosis and parakeratosis, hypergranulosis, acanthosis, and moderate perivascular [jamanetwork.com]

Unspecific, showing orthohyperkeratosis and epithelial hyperplasia with hypergranulosis. [plasticsurgerykey.com]

Punctate Palmoplantar Keratoderma Type 1

Although not specific for PPKP1, histological examination of papules reveals hypergranulosis and hyperkeratosis with a well-defined central epidermal depression. [orpha.net]

Hypergranulosis, acanthosis and a sparse perivascular lymphocytic infiltrate can also be seen in PPPK. 4 Figure 3. [the-dermatologist.com]

In the biopsy, compact orthohyperkeratosis, hypergranulosis, and slight acanthosis were seen (Fig. 1c). [docksci.com]

Actinic Lichen Planus

Histological findings showed compact hyperkeratosis, wedge-shaped hypergranulosis, saw-toothed hyperplasia, coarse basal cell vacuolization, and civatte bodies. [odermatol.com]

Typical features include: Irregularly thickened epidermis Wedge-shaped hypergranulosis, ‘saw-tooth’ shaped rete ridges Civatte bodies (apoptotic keratinocytes) in the lower [dermnetnz.org]

Pigmented Lichen Planus

Civatte bodies Eosinophils Hypergranulosis Hyperkeratosis Board review style answer #2 B. Eosinophils. [pathologyoutlines.com]

[…] palmoplantar areas are not affected by the disease.2-4,6 Histologically there is a pattern compatible with lichen planus in regression, with minor or absent hyperkeratosis and hypergranulosis [ncbi.nlm.nih.gov]

Histologically there is a pattern compatible with lichen planus in regression, with minor or absent hyperkeratosis and hypergranulosis, and even, in some cases, atrophic epidermis [scielo.br]

Palmoplantar Keratoderma Type Bothnian

Histologic findings include hyperkeratosis, hypergranulosis, and acanthosis. [emedicine.medscape.com]

It is primarily characterized by hyperkeratosis, hypergranulosis, and incomplete keratosis of the epidermis, hypertrophy of the granular layer and spinous layer, infiltration [hindawi.com]

Histologic findings include orthokeratotic hyperkeratosis associated with hypergranulosis or hypogranulosis and moderate acanthosis. [emedicine.medscape.com]

Autosomal Recessive Congenital Ichthyosis Type 8

Stewart-H; Smith-PT; Gaunt-L; Moore-L; Tarpey-P; Andrew-S; Dady-I; Rifkin-R; Clayton-Smith-J De novo deletion of chromosome 18q in a baby with harlequin ichthyosis AMERICAN-JOURNAL-OF-MEDICAL-GENETICS. SEP 1 2001; 102 (4) : 342-345 Baek-SC; Lin-Q; Robbins-PB; Fan-HR; Khavari-PA Sustainable systemic delivery via[…] [malattierare.regione.veneto.it]

Inverted Follicular Vulvar Keratosis

Clear glycogenated cells, palisaded basilar layer and thickened basement membrane Verruca vulgaris: More exophytic than endophytic with inward curving papillomatosis, coarse hypergranulosis [pathologyoutlines.com]

Keratoderma Palmoplantaris Transgrediens

—There is epidermal hyperplasia with hypergranulosis, a thin layer of parakeratosis, and overlying orthokeratosis. [escholarship.org]

A, A biopsy specimen from the dorsum of the hand shows orthokeratotic hyperkeratosis with acanthosis, hypergranulosis, and mild perivascular inflammatory infiltration. [jamanetwork.com]

Histopathological findings Biopsy specimens revealed hyperkeratosis with areas of orthokeratosis and parakeratosis, hypergranulosis, acanthosis, and moderate perivascular [jamanetwork.com]

Familial Pachydermodactyly

Histopathologic examination of a biopsy specimen revealed hyperkeratosis, hypergranulosis overlying a markedly thickened dermis, consisting of increased collagen bundles sometimes [mcmaster.ca]

Ichthyosis Hystrix Type Curth-Macklin

[…] methodsDiagnosis is based on clinical examination and on histological examination of skin lesion biopsies revealing papillomatous hyperplasia with hyperorthokeratosis and hypergranulosis [malacards.org]

[…] methods Diagnosis is based on clinical examination and on histological examination of skin lesion biopsies revealing papillomatous hyperplasia with hyperorthokeratosis and hypergranulosis [rarediseases.info.nih.gov]