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278 Possible Causes for Hypergranulosis

  • Actinic Lichen Planus

    In the epidermis, there is wedge-shaped hypergranulosis, compact orthokeratosis, and apoptotic keratinocytes along the basal layer.[] The histological examination (Fig. 2) showed compact, wedge-shaped hypergranulosis, elongated epidermal crests, coarse basal cell vacuolization and Civatte bodies.[] Arrows: basal layer colliquation (green), melanophages (orange), hyperkeratosis (red), wedge hypergranulosis (blue) FIGURE 4 Strip Inflammatory infiltrate (circle), pigmentary[]

  • Palmoplantar Keratosis

    Histological findings include hyperkeratosis, hypergranulosis, and acanthosis.[] —There is epidermal hyperplasia with hypergranulosis, a thin layer of parakeratosis, and overlying orthokeratosis.[] Histopathologic examination revealed orthohyperkeratosis within focal clavus‐like depressions of the epidermis and prominent hypergranulosis.[]

  • Verruca Vulgaris

    Hypergranulosis (thicker stratum granulosum). Papillomatous hyperplasia : Rete ridge lengthening ( 7-10x normal) and thickening.[] […] types 2 and 4; the lesions are of variable duration, eventually undergoing spontaneous regression, and are both exophytic and endophytic, with hyperkeratosis, parakeratosis, hypergranulosis[] LM papillomatous hyperplasia (rete ridges long & curve inward), hyperkeratosis, hypergranulosis, large blood vessels at the dermal-epidermal junction, /-viral changes - perinuclear[]

  • Bullous Lichen Planus

    Histopathological examination with hematoxylene and eosin stain revealed parakeratosis with hypergranulosis and mild basal cell hyperplasia.[] The histological examination of the papular lesion showed hypergranulosis, degeneration of the basal layer, lymphocytic band infiltrate in the superficial dermis (Fig. 3 and[] Histopathology from a bullous lesion, (A) with subepidermal clefting (H&E, 10) and (B) with hypergranulosis and sawtooth-like acanthosis (H&E, 40).[]

  • Epidermodysplasia Verruciformis

    The histopathologic features of EV consist of papillated epidermal hyperplasia with hypergranulosis and a distinct bluish-gray color in the large human papillomavirus-infected[] Areas of epidermis showed compact orthokeratosis, coarse hypergranulosis, and keratinocytes with abundant steel-blue-gray cytoplasm, indicative of viral cytopathic changes[] Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm.[]

  • Diffuse Palmoplantar Keratoderma

    Histopathological examination of the skin biopsy taken from the patient’s sole revealed orthokeratotic hyperkeratosis, hypergranulosis and acanthosis without epidermolysis[] Histologic findings include hyperkeratosis, hypergranulosis, and acanthosis.[] , and acanthosis (PPK) Birth-Adolescence Yes No H H Compact hyperkeratotsis, hypergranulosis, and acanthosis, subepidermal vessels were dilated, mild mononuclear cell infiltrate[]

  • Pityriasis Rubra Pilaris

    Occasionally, mild spongiosis with scattered intraepidermal lymphocytes In early lesions, parakeratosis is poorly developed and lamellar ortho hyperkeratosis predominates; hypergranulosis[] […] histologic) description Biopsy from non-follicular lesion consists of alternating orthokeratosis and parakeratosis in both vertical and horizontal directions Focal or confluent hypergranulosis[]

  • Papillon Lefevre Disease

    Skin biopsy shows hyperkeratosis with focal parakeratosis, moderate perivascular infiltration, hypergranulosis, and acanthosis.[] Histhopathologic examination of the hyperkeratotic plantar skin revealed hyperkeratosis, hypergranulosis, acanthosis and a dense perivascular lymphocytic infiltration.[]

  • Lichen Planus

    They differ from those of cutaneous disease in several respects, including the presence of parakeratosis, epithelial atrophy, and lack of hypergranulosis.[] LP has an associated set of characteristic histopathologic findings which include hyperkeratosis, vacuolization of the basal layer, Civatte bodies, wedge-shaped hypergranulosis[] Biopsy of a lesion revealed hyperkeratosis, wedge-shaped hypergranulosis, sawtooth rete pegs, and bandlike lymphocytic inflammation — findings confirming the diagnosis of[]

  • Lichen Simplex Chronicus

    Histologically, the lesions were characterized by moderate to marked hyperorthokeratosis and wedge-shaped hypergranulosis.[] As a consequence, there are compact orthokeratosis, hypergranulosis, uneven psoriasiform acanthosis, and coarse bundles of collagen arranged in vertical streaks in a thickened[] Histologic Features: Prominent irregular acanthosis (the rete ridges are of varying length) Hyperkeratosis, sometimes with focal parakeratosis, and hypergranulosis Vertically[]

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