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34 Possible Causes for Hyperinflammatory State

  • Hypersensitivity

    CGD is known to cause a hyperinflammatory state and the patients present with excessive granuloma formation and HP.[ncbi.nlm.nih.gov]

  • Streptococcus Pyogenes

    Considering the hyperinflammatory state of these severe tissue infections, such effects would likely exacerbate the pathological responses and worsen the disease progression[academic.oup.com] state that characterizes these infections [ 25 , 49–52 ].[academic.oup.com] […] the presence of neutrophil proteins at the infected tissue site, including heparin-binding protein, IL-8, resistin, and LL-37, all of which are likely to contribute to the hyperinflammatory[academic.oup.com]

  • Sepsis

    states.[ncbi.nlm.nih.gov] […] human‐activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo‐ and hyperinflammatory[doi.org] […] human-activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo- and hyperinflammatory[ncbi.nlm.nih.gov]

  • Septicemia

    states.[ncbi.nlm.nih.gov] […] human‐activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo‐ and hyperinflammatory[dx.doi.org] […] human-activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo- and hyperinflammatory[ncbi.nlm.nih.gov]

  • Interstitial Lung Disease

    CGD is known to cause a hyperinflammatory state and the patients present with excessive granuloma formation and HP.[ncbi.nlm.nih.gov]

  • Lafora Disease

    state IgA: Increased Memory B cells: Decreased Lymphadenopathy Laboratory Muscle NADH: Irregular internal architecture Normal glycogen: Depleted in 50% of muscle fibers Polyglucosan[neuromuscular.wustl.edu] […] progressive; May require transplant Liver involvement (20%): Hepatomegaly Skeletal Growth retardation (40%) Scoliosis (30%) Immunodeficiency (Some patients) Recurrent infections Hyperinflammatory[neuromuscular.wustl.edu]

  • Blast Injury

    This hyperinflammatory state manifested as hyperpyrexia, sweating, low central venous pressure, and positive fluid balance.[ncbi.nlm.nih.gov] state Fever Diaphoresis Low central venous pressure Tissue edema The supersonic blast wave in primary blast injury (PBI) compresses gas-filled spaces, which then rapidly[merckmanuals.com] Unconventional materials used in the manufacture of the explosive can partly explain the observed early hyperinflammatory state.[ncbi.nlm.nih.gov]

  • Blast Lung

    state Fever Diaphoresis Low central venous pressure Tissue edema The supersonic blast wave in primary blast injury (PBI) compresses gas-filled spaces, which then rapidly[merckmanuals.com] Quinary Thought to result from toxic materials absorbed by the body from the blast Affects the immune system and perhaps the autonomic nervous system, leading to an immediate hyperinflammatory[merckmanuals.com]

  • Antiphospholipid Syndrome

    Treatment of the acute emergency requires anticoagulation, suppression of the hyperinflammatory state and elimination of the triggering infection.[ncbi.nlm.nih.gov]

  • Chronic Granulomatous Disease

    CGD patients displayed evidence for a chronic hyperinflammatory state as indicated by elevated plasma IL-1β and TNF-α levels.[ncbi.nlm.nih.gov] Patients with recurrent pyogenic infections developed fibrosis and hyperinflammatory states with granuloma formation.[ncbi.nlm.nih.gov]

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