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18 Possible Causes for Hyperintensities in the Globus Pallidus (T2-Weighted), Hyperreflexia, Pyramidal Tract Signs

Did you mean: Hyperintensities in the Globus Pallidus (T2-Weighted, Hyperreflexia, Pyramidal Tract Signs

  • Hallervorden-Spatz Syndrome

    Table-1: Diagnostic features of Hallervorden spatz disease [11] Obligate Features Collaborate Features Exclusion Features Onset during first two decades Pyramidal tract signs[medresearch.in] This virtually pathognomonic radiographic abnormality, called the eye-of-the-tiger sign, comprises hyperintensities within a hypointense medial globus pallidus on T2-weighted[ncbi.nlm.nih.gov] Neurologically, opisthotonus, rigidity of extremities, dystonia, hyperreflexia, profound emaciation, and bilaterally positive Babinski signs were present.[ncbi.nlm.nih.gov]

  • Central Pontine Myelinolysis

    In (CPM), the initial signs include dysarthria and dysphagia (secondary to corticobulbar fiber involvement), and flaccid quadriparesis (from pyramidal tract involvement) which[omicsonline.org] […] of Globus Pallidus (broad arrow), suggestive of Extrapontine myelinolysis.[ipfs.io] ., horizontal gaze paralysis), impaired speech or swallowing, and signs of spastic quadriplegia such as limb weakness, increased tonicity of the limb muscles, and hyperreflexia[symptoma.com]

  • Binswanger Disease

    The bilateral cerebral white matter and globus pallidus appeared hyperintense on T2-weighted imaging (Figures 5 and 6). 5) Figure 5. CO poisoning(FLAIR image) Figure 6.[plaza.umin.ac.jp] In addition, focal neurological deficits are commonly observed, most prominent being those involving the upper motor neurons (UMNs) - muscle rigidity, hyperreflexia (often[symptoma.com] Autosomal recessive inheritance Babinski sign Dementia Diffuse demyelination of the cerebral white matter Diffuse white matter abnormalities Dysarthria Gait disturbance Hyperreflexia[familydiagnosis.com]

  • Neuroferritinopathy

    tract signs, and psychiatric symptoms.[ncbi.nlm.nih.gov] pallidus, on T2-weighted images.[emedicine.medscape.com] Disinhibition 0000734 Dysarthria Difficulty articulating speech 0001260 Dyskinesia Disorder of involuntary muscle movements 0100660 Emotional lability Emotional instability 0000712 Hyperreflexia[rarediseases.info.nih.gov]

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    tract signs with heavy iron accumulation at the globus pallidum and the substantia nigra [ 1, 2 ].[omicsonline.org] Key Diagnostic Features: Once the parkinsonian symptoms appear, brain MRI shows hypointensity in the region of substantia nigra (SN) and globus pallidus (GP) on T2-weighted[ajnr.org] Most patients have progressive involvement of the corticospinal tract, with spasticity, hyperreflexia, and extensor plantar responses.[genecards.org]

  • Neurodegeneration with Brain Iron Accumulation

    . • Begins in childhood • Profound dystonia, dysarthria, spasticity and pyramidal tract signs • Pigmentary retinopathy, leading to night blindness and visual field constriction[slideshare.net] Even before the globus pallidus hypointensity developed, patients with mutations could be distinguished by the presence of isolated globus pallidus hyperintensity on T2-weighted[ncbi.nlm.nih.gov] […] associated neurodegeneration (PLAN) –Infantile neuroaxonal dystrophy (INAD) PLA2G autosomal recessive Severe psychomotor regression, hypotonia, peripheral motor neuropathy, hyperreflexia[ojrd.biomedcentral.com]

  • Alexander Disease

    We report a case of genetically confirmed adult-onset AD with palatal myoclonus, pyramidal tract signs, cerebellar signs, and marked atrophy of the medulla oblongata and spinal[ncbi.nlm.nih.gov] In addition, there are symmetrical hyperintensity signals in the posterior part of the globus pallidus on T2-weighted images in the two symptomatic patients, which are rarely[ncbi.nlm.nih.gov] While the infantile form presents with ataxia, hyperreflexia, and other upper motor neuron symptoms, none of these has been observed in the neonatal form.[ncbi.nlm.nih.gov]

  • Infantile Dystonia - Parkinsonism

    signs.[medical-dictionary.thefreedictionary.com] […] signal on T2-weighted scans.[e-jmd.org] […] spastic paraplegias (HSPs) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity, weakness and hyperreflexia[ashg.org]

  • Endemic Cretinism

    The 10 others were clinically euthyroid and had deaf-mutism and/or pyramidal tract dysfunction (neurological cretinism).[ncbi.nlm.nih.gov] All show an apparent magnetic resonance imaging abnormality in the globus pallidus and substantia nigra, with hyperintensity on T1-weighted images and hypointensity on T2-[ncbi.nlm.nih.gov] Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar[ncbi.nlm.nih.gov]

  • Kufor-Rakeb Syndrome

    tract signs, supranuclear gaze palsy, and severe cognitive decline. 3,5 On the contrary, in our homozygous case the atypical features were limited to an impaired upward gaze[healthdocbox.com] pallidus, on T2-weighted images.[emedicine.medscape.com] Torticollis Slow saccadic eye movements Supranuclear gaze palsy Aggressive behavior Psychotic episodes Dementia Hallucinations Seizures Spasticity Parkinsonism Myoclonus Hyperreflexia[familydiagnosis.com]

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