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31 Possible Causes for Hyperintensities in the Globus Pallidus (T2-Weighted), Mental Retardation

Did you mean: Hyperintensities in the Globus Pallidus (T2-Weighted, Mental Retardation

  • Hallervorden-Spatz Syndrome

    This virtually pathognomonic radiographic abnormality, called the eye-of-the-tiger sign, comprises hyperintensities within a hypointense medial globus pallidus on T2-weighted[] Clinical presentations include dystonia, dysarthria, dementia, severe mental retardation and ataxia with rare features as rigidity, choreoathetosis, seizures, optic atrophy[] […] pattern of hyperintensity within the hypointense medial globus pallidus.[]

  • Alexander Disease

    In addition, there are symmetrical hyperintensity signals in the posterior part of the globus pallidus on T2-weighted images in the two symptomatic patients, which are rarely[] The patient initially presented at 9 months of age, with profound mental retardation and a history of seizures.[] Diffuse white matter involvement with frontal predominance is typical of infantile AD that is clinically characterized by progressive motor and mental retardation, seizures[]

  • Fucosidosis

    Figure 2: Magnetic resonance imaging brain T2-weighted axial image showing hypointensity of globus pallidus bilaterally and the subcortical hyperintensity (a), T1-weighted[] The early symptom of anterior beaking of the vertebral bodies, in combination with mental retardation and angiokeratoma corporis diffusum, can suggest the possibility of type[] Individuals usually have mild coarsening of facial features, dysostosis multiplex, mental retardation enlarged liver, spleen and/or heart involvement.[]

  • Neurofibromatosis Type 1

    Rarely, hyperintensities and mild mass effect have been reported in the globus pallidus on T1-weighted images.[] All patients with uncontrolled seizures had severe mental retardation, and three of these had malformations of cortical development.[] A much smaller percentage experience more significant cognitive difficulties such as mild or moderate mental retardation.[]

  • Bilirubin Encephalopathy

    In the appropriate clinical context, bilateral globus pallidus T2-weighted and FLAIR signal hyperintensity is supportive of a diagnosis of kernicterus in an infant.[] retardation.[] Patients surviving kernicterus have severe permanent neurologic symptoms ( choreoathetosis, spasticity, hearing loss, ataxia, mental retardation ).[]

  • Woodhouse Sakati Syndrome

    Axial FLAIR- (A) and GRE T2-weighted (B) MRI discloses ‘ eye-of- the-tiger ’ sign, defined as a medial area of hyperintense signal within an hypointense signal in globus pallidus[] A syndrome of hypogonadism, alopecia, diabetes mellitus, mental retardation, deafness, and ECG abnormalities.[] Disorder, Progressive, With Primary Hypogonadism, Mental Retardation, and Alopecia Hypogonadism, Alopecia, Diabetes Mellitus, Mental Retardation, Deafness, and Extrapyramidal[]

  • Endemic Cretinism

    All show an apparent magnetic resonance imaging abnormality in the globus pallidus and substantia nigra, with hyperintensity on T1-weighted images and hypointensity on T2-[] The study covers 19 mental defectives (11 females and 8 males, mean age 35.8 /- 15.5 yr) selected on the basis of severe mental retardation recognized by the local doctors[] The latter have been described as less mentally retarded but with severe growth retardation and myxedematous features.[]

  • 2-Hydroxyglutaric Aciduria

    In 43 patients (77%) the globus pallidus was more hyperintense on the T2-weighted MR images than the caudate nucleus and putamen ( , Fig 5 ).[] Patients present a very slowly progressive deterioration with cerebellar ataxia, mild or severe mental retardation, and various other clinical signs including extrapyramidal[] In this report, we present an rare 8-year-old patient with a rare mental retardation, cerebellar findings, macrocephaly and typical brain MRI findings, who was subsequently[]

  • Neurodegeneration with Brain Iron Accumulation

    Even before the globus pallidus hypointensity developed, patients with mutations could be distinguished by the presence of isolated globus pallidus hyperintensity on T2-weighted[] retardation, retinitis pigmentosa and iron accumulation in the brain.[] A syndrome of hypogonadism, alopecia, diabetes mellitus, mental retardation, deafness, and ECG abnormalities.[]

  • Autosomal Dominant Progressive External Ophthalmoplegia Type 6

    T2-weighted axial MR image demonstrates bilateral hyperintense signal abnormalities in the globus pallidus (arrows).[] RETARDATION; MCLMR Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation is an autosomal dominant disorder that involves an overlapping but variable[] RETARDATION, X-LINKED, SYNDROMIC, WU TYPE; MRXSW MENTAL RETARDATION, X-LINKED, SYNDROMIC, WU TYPE; MRXSW Is also known as mental retardation, x-linked 94;mrx94, mental retardation[]

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