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12 Possible Causes for Hyperintensities in the Globus Pallidus (T2-Weighted), Stupor

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  • Wernicke Encephalopathy

    In untreated patients, stupor may progress to coma, then to death. There are no specific diagnostic studies.[merckmanuals.com] […] in the globus pallidus.[ncbi.nlm.nih.gov] The most common presenting symptoms of WE are mental status changes. [5] Stupor and coma are rare manifestations of WE.[emedicine.medscape.com]

  • Central Pontine Myelinolysis

    Large lesions cause spastic bulbar paralysis, quadriplegia, stupor or coma, or the locked-in syndrome, developing in a background of severe electrolyte abnormalities.[neuropathology-web.org] […] of Globus Pallidus (broad arrow), suggestive of Extrapontine myelinolysis.[ipfs.io] Clinical manifestations of CPM include stupor and spastic tetraparesis[ 51 ].[dx.doi.org]

  • Creutzfeldt Jakob Disease

    Polioencefalopatia degenerativa subacura del presenio con stupore acinetico e rigidit: decorticata con mioclonie (Varier; “rnioclonica” della malattia di Jakob Creutzfeldt[academic.naver.com] Extrapontine myelinolysis manifests predominantly as areas of bilateral FLAIR /T2-weighted imaging hyperintensity in the globus pallidus, putamen, and thalamus, which are[doi.org] Polioencefalopatia degenerativa subacuta del presenio con stupore acinetico e rigidita decorticata con mioclonie (Varieta ‘mioclonica’ della malattia di Jakob-Creutzfeldt)[doi.org]

  • Hallervorden-Spatz Syndrome

    Other symptoms of HSD include: rigid muscles writhing movements tremors a lack of balance when walking, or ataxia seizures confusion disorientation stupor dementia weakness[healthline.com] This virtually pathognomonic radiographic abnormality, called the eye-of-the-tiger sign, comprises hyperintensities within a hypointense medial globus pallidus on T2-weighted[ncbi.nlm.nih.gov] […] pattern of hyperintensity within the hypointense medial globus pallidus.[ncbi.nlm.nih.gov]

  • Neurodegeneration with Brain Iron Accumulation

    […] uncontrolled tightness of the muscles), spasticity (sudden, involuntary muscle spasms), and/or ataxia (inability to coordinate movements), confusion, disorientation, seizures, stupor[ninds.nih.gov] Even before the globus pallidus hypointensity developed, patients with mutations could be distinguished by the presence of isolated globus pallidus hyperintensity on T2-weighted[ncbi.nlm.nih.gov] Symptoms include involuntary muscle contractions, rigidity and spasms in the limbs, face and torso, as well as confusion, disorientation, seizures, stupor and dementia.[news-medical.net]

  • Kernicterus

    […] tone (hypotonia) Middle stage: High-pitched cry Irritability May have arched back with neck hyperextended backwards, high muscle tone (hypertonia) Poor feeding Late stage: Stupor[medlineplus.gov] In the appropriate clinical context, bilateral globus pallidus T2-weighted and FLAIR signal hyperintensity is supportive of a diagnosis of kernicterus in an infant.[imj.ie] A limited investigation of diffusion-weighted imaging (DWI) showed no distinctive signal pattern, but a larger study is required.[imj.ie]

  • Binswanger Disease

    In severe cases of anoxia the patient may be in a stupor or a coma for periods ranging from hours to days, weeks, or months.[alzheimersweekly.com] The bilateral cerebral white matter and globus pallidus appeared hyperintense on T2-weighted imaging (Figures 5 and 6). 5) Figure 5. CO poisoning(FLAIR image) Figure 6.[plaza.umin.ac.jp] ., tentorial and foramen magnum herniation; see Chapter 17 on stupor and coma).[dartmouth.edu]

  • Encephalopathy

    Stupor and "twitching" Case #5 A 56-year-old man who was previously well was admitted to the hospital in a stupor with clonic twitching of his left extremities and face.[dartmouth.edu] Conventional MRI may reveal hyperintense signal on T1-weighted images in the globus pallidus, subthalamic region, and midbrain, and may also show diffuse cortical edema and[ajronline.org] The features of HE depend on the aetiology and precipitating factors, eventually developing into stupor and then coma. some aetiologies of the hepatic failure, for example[gpnotebook.co.uk]

  • Wilson Disease

    In the third stage, the patient is stuporous and barely responsive. In the fourth stage, the patient sinks into deep coma.[intranet.tdmu.edu.ua] On T1W images, these lesions are normal to hypointense but hyperintense lesions especially in globus pallidus may also be seen [ 2 ].[omcr.oxfordjournals.org] The lesions showed no signal-intensity abnormality on T2-weighted images. The cause of hyperintensity in T1-weighted images remains elusive.[ajnr.org]

  • Cyanide Poisoning

    Neurotoxicity occurs at modest doses; initially there is CNS stimulation (dizziness, confusion, restlessness, and anxiety) which is followed by stupor, opisthotonus, convulsions[derangedphysiology.com] […] recovery images in the region of the striatum and the globus pallidus.[ajnr.org] Thiocyanate toxicity is characterized by weakness, muscle spasm, nausea, disorientation, psychosis, hyper-reflexia, and stupor (Smith, 1973; Michenfelder & Tinker, 1977).[web.archive.org]

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