Hyperkeratosis Causes & Reasons

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Hyperkeratosis Symptom Checker: Possible causes include Acanthosis Nigricans. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Hyperkeratosis,

Negated

None

Unsure

None

Possible Causes

Acanthosis Nigricans

A biopsy was performed, and histologic analysis revealed acanthosis and papillomatosis, hyperkeratosis, increased dermal pigmentation, and a dermal lymphohistiocytic infiltrate [doi.org]

Abstract Acanthosis nigricans is a mucocutaneous dermatosis characterized by hyperpigmentation and a velvety papillomatous hyperkeratosis. [ncbi.nlm.nih.gov]

Acanthosis nigricans (AN) is a skin disorder characterized by focal or diffuse hyperkeratosis symmetric hyperpigmentation of the skin and oral cavity mucosa. [ncbi.nlm.nih.gov]

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Lymphedema

[…] of scrotum Lymphedema of uncertain etiology Lymphedema of vulva Lymphedema praecox Lymphedema, after surgery Lymphedema, limb Lymphedema, lower extremity Lymphedematous hyperkeratosis [icd9data.com]

Hyperkeratosis and papillomas may also be seen in someone with lymphedema. Hyperkeratosis is an overgrowth of the skin like a very thick callus. [oncolink.org]

Stage III lymphedema is characterized by a tremendous increase in volume, hardening of the dermal tissues, hyperkeratosis, and papillomas of the skin. [nortonschool.com]

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Ichthyosis Vulgaris

Abstract To elucidate the pathogenesis of impaired barrier function and the influence of surfactant on the stratum corneum in hyperkeratosis, we investigated morphological [ncbi.nlm.nih.gov]

Hence, this type of hyperkeratosis can be distinguished from other types of inherited palmoplantar keratosis. [ncbi.nlm.nih.gov]

Abstract Ichthyosis vulgaris is an autosomal dominant disorder of keratinization characterized by mild hyperkeratosis and reduced or absent keratohyalin granules in the epidermis [ncbi.nlm.nih.gov]

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Carcinoid Tumor

Skin hyperkeratosis and pigmentation and arthritis are also relatively uncommon. [emedicine.medscape.com]

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Actinic Keratosis

The features in favour of AK were parakeratosis, hyperkeratosis, more severe keratinocyte pleomorphism and architectural disruption, and the presence of epidermal inflammatory [ncbi.nlm.nih.gov]

Validation of the AK-FAS showed good reproducibility for AK area and hyperkeratosis, even for dermatologists untrained on use of the scale. [ncbi.nlm.nih.gov]

Hyperkeratosis represents the most important limitation in the evaluation of squamous neoplasia as it may impair the analysis of deeper epidermal and dermal structures significantly [ncbi.nlm.nih.gov]

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Cutaneous T-Cell Lymphoma

[…] cells Can be an advanced form of mycosis fungoides or arise de novo Characteristic triad of symptoms Systemic skin lesions Erythroderma accompanied by palmar and plantar hyperkeratosis [amboss.com]

Case 1 A male patient, aged 30 years, was admitted to our Department with extremely itchy erythroderma with generalized peripheral lymphadenopathy and hyperkeratosis of the [cyberleninka.org]

Ichthyosiform MF has similar histopathologic findings to classic MF combined with features of ichthyosis, such as hypogranulosis and hyperkeratosis.25 The detection of features [actasdermo.org]

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Onychomycosis

The infection was characterised clinically by yellowish pigmentation of the nail plate and mild nail bed hyperkeratosis of the first left toe. [ncbi.nlm.nih.gov]

The infection was characterized clinically by yellow-brown discoloration of the nail plate, distal-lateral onycholysis and subungual hyperkeratosis of the first left toenail [ncbi.nlm.nih.gov]

If less than 2 mm of hyperkeratosis is present, no points are awarded. [jamanetwork.com]

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Alcoholic Neuropathy

Abstract Characteristics of alcoholic neuropathy have been obscured by difficulty in isolating them from features of thiamine-deficiency neuropathy. We assessed 64 patients with alcoholic neuropathy including subgroups without (ALN) and with (ALN-TD) coexisting thiamine deficiency. Thirty-two patients with[…] [ncbi.nlm.nih.gov]

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Fitzsimmons-McLachlan-Gilbert Syndrome

[…] is hyperkeratosis of the sole of the foot. [en.wikipedia.org]

Some types of hyperkeratosis are inherited conditions. They may be present at birth. Other kinds of hyperkeratosis may be early signs of skin cancer. [healthline.com]

[…] often, hyperkeratosis develops on skin that has not been irritated. [drugs.com]

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Generalized Pustular Psoriasis

[…] differentiation of keratinocytes and parakeratosis; lesions characteristically affect extensor surfaces, scalp and trunk; nails become dystrophic, showing onycholysis, subungual hyperkeratosis [medical-dictionary.thefreedictionary.com]

Palmoplantar pustulosis: The characterizing feature of this variety is hyperkeratosis and clusters of sterile, yellow pustules on a background of erythema and scaling, affecting [intechopen.com]

Examination revealed dystrophic nails manifested by subungual hyperkeratosis and pustules, yellowish discolouration, and onycholysis, and the dorsal tongue was oedematous [emjreviews.com]

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Leukoplakia

What is Hyperkeratosis? Hyperkeratosis is a layered buildup of keratinized cell tissue and is distinctive for its leaf-like appearance. [entcolumbia.org]

Histopathology of leukoplakia can disclose hyperkeratosis with dysplasia or carcinoma or hyperkeratosis or parakeratosis without dysplasia. [ncbi.nlm.nih.gov]

PVL generally presents as a simple benign form of hyperkeratosis that tends to spread and become diffuse. [ncbi.nlm.nih.gov]

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Confluent and Reticulated Papillomatosis

We observed invagination of basket-weave hyperkeratosis through the epidermis. [ncbi.nlm.nih.gov]

The histologic findings include papillomatosis, hyperkeratosis, and minimal or no acanthosis. [ncbi.nlm.nih.gov]

Histopathologically, hyperkeratosis, decreased granular layer, irregular papillomatosis, and hypermelanosis of the basal layer were present. [ncbi.nlm.nih.gov]

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Palmoplantar Keratosis

0 ratings Abstract: We report a rare genetic condition characterized by gingival hyperkeratosis with skin changes affecting the hands and feet. [dental-update.co.uk]

We present a case of focal acral hyperkeratosis in a 9‐year‐old girl. [www3.interscience.wiley.com]

Clinical relevance: To inform clinicians of both the intra-oral and extra-oral features of focal palmoplantar and gingival hyperkeratosis. [dental-update.co.uk]

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Hypochondroplasia

Acanthosis nigricans (AN) is a velvety and papillomatous pigmented hyperkeratosis of the skin, which has been recognized in some genetic disorders more severe than HCH involving [ncbi.nlm.nih.gov]

Moreover, insulin resistance and the appearance of acanthosis nigricans, a papillomatous pigmented hyperkeratosis of the skin appearing on the flexures of the neck in most [symptoma.com]

AN is a velvety and papillomatous pigmented hyperkeratosis of the skin, which appears mainly on the flexures and neck. [eje.bioscientifica.com]

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Papillon Lefevre Disease

Patients may also present with malodorous hyperhidrosis, follicular hyperkeratosis, nail dystrophy or dural calcifications. [rarediseases.info.nih.gov]

Keywords: Papillon-Lefèvre Syndrome, Periodontitis, Palmoplantar, Hyperkeratosis, Cathepsin C 1. [slideshare.net]

Pa·pil·lon-Le·fèv·re syn·drome ( pah-pē-on[h]' le-fĕv ), [MIM*245000] a congenital hyperkeratosis of the palms and soles, with progessive destruction of alveolar bone about [medical-dictionary.thefreedictionary.com]

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Diffuse Palmoplantar Keratoderma

On examination, diffuse hyperkeratosis of the palms and soles was observed (Figure 1 a, b) However, there was no extension of this hyperkeratosis to the dorsal aspects of [ncbi.nlm.nih.gov]

These findings suggested an association between internal malignancy and palmoplantar hyperkeratosis. [ncbi.nlm.nih.gov]

Fig. 2 Hyperkeratosis sparing the arches of feet. [indianpediatrics.net]

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Howell-Evans Syndrome

ESOPHAGEAL CANCER Palmoplantar Keratoderma With Esophageal Cancer TOC Keratosis palmaris et plantaris with esophageal cancer TYLOSIS WITH ESOPHAGEAL CANCER; TOC Palmoplantar hyperkeratosis-esophageal [wikidata.org]

Symptoms and Signs Some symptoms of Howel-Evans syndrome include hyperkeratosis of palms, hyperkeratosis of the soles of the feet, and esophageal cancer. [dianamossop.com]

Potential Signs and Symptoms Some symptoms of Howel-Evans syndrome consist of hyperkeratosis of palms, hyperkeratosis of the soles of the feet, and esophageal cancer. [besttreatmenthq.com]

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Hidrotic Ectodermal Dysplasia

Also, skin emollients, keratolytics, and other therapies may be used for the hyperkeratosis. [symptoma.com]

Hidrotic ectodermal dysplasia is a rare genodermatosis with clinical hallmarks of alopecia, nail dystrophy, and palmoplantar hyperkeratosis. [ncbi.nlm.nih.gov]

Clouston's syndrome is an ectodermal dysplasia characterized by dystrophic nails, alopecia, and palmoplantar hyperkeratosis. [ncbi.nlm.nih.gov]

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Zinc-Responsive Necrolytic Acral Erythema

This patient also had hyperkeratosis of the palms and soles and involvement of the face. [emedicine.medscape.com]

Others have noted epidermal necrosis with or without blister formation; vacuolar degeneration of the basal layer; and psoriatic changes with acanthosis, papillomatosis, hyperkeratosis [slideshare.net]

Histopathology mostly showed hyperkeratosis, acanthosis, prominent granular layer, spongiosis and dermal infiltrate. [ingentaconnect.com]

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Vulvar Dystrophy

Fifteen patients had lichen sclerosus with various degrees of hyperkeratosis, while one had human papillomavirus-associated vulvar intraepithelial neoplasia and another had [ncbi.nlm.nih.gov]

[…] or parakeratosis Nuclear atypia not seen Microscopic (histologic) images Images hosted on other servers : Mild hyperkeratosis Epithelial thickening Chronic inflammatory cell [pathologyoutlines.com]

Eczematous inflammation or hyperkeratosis may be present. Prevalence: Common, 40% to 45% of non-neoplastic epithelial disorders. [clinicalgate.com]

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Angiokeratoma Circumscriptum

Angiokeratomas are benign cutaneous lesions characterized by ectasia of papillary dermis vessels and secondary epidermal changes like hyperkeratosis. [symptoma.com]

The type of lesion varied from discrete macules with no or slight hyperkeratosis to confluent, protruding verrucous plaques. [ncbi.nlm.nih.gov]

Angiokeratomas are relatively rare vascular lesions characterized by ectasias of the papillary dermal blood vessels with secondary epidermal changes in the form of acanthosis and/or hyperkeratosis [ncbi.nlm.nih.gov]

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Bazex Syndrome

The patient's skin disease was more remarkable for its hyperpigmentation than its hyperkeratosis. [ncbi.nlm.nih.gov]

Squames / scales Pathophysiology genetic disorders / keratinocyte genetic disorders / palmoplantar keratoderma Symptoms Burning, Diagnosis hyperkeratosis palmaris et plantaris [dermquest.com]

Histology of plantar skin revealed compact hyperkeratosis and irregular epidermal hyperplasia. Mycosis was excluded histologically. [bmccancer.biomedcentral.com]

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Kraurosis Vulvae

However, the main histological features of kraurosis vulvae are nonspecific (luminal hyperkeratosis, acanthosis, infiltration of lymphocytes, thickening of the basement membrane [symptoma.com]

When kraurosis vulva there is atrophy and hyperkeratosis of stratified squamous epithelium proliferation of fibrous connective tissue, leading to distortion and reduction [medicalformat.com]

Convert to ICD-10-CM : 624.09 converts approximately to: 2015/16 ICD-10-CM N90.4 Leukoplakia of vulva Approximate Synonyms Dystrophy of vulva Hyperkeratosis of vulva Leukoplakia [icd9data.com]

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Thallium Poisoning

Approximately 1 month after thallium exposure, Mees lines (transverse white lines on the nails) appear in the nail plate. [22] Other dermatologic findings include well-demarcated hyperkeratosis [emedicine.medscape.com]

Skin and nail symptoms include hardened patches of skin (hyperkeratosis) with unusually deep creases on the palms of the hands and the soles of the feet, unusual darkening [rarediseases.org]

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Arsenical Keratosis

[…] is hyperkeratosis of the sole of the foot. [en.wikipedia.org]

Patient case no. 2022 Date added 18 May 2003 Patient details Age --Undetermined-- Localisation Upper limbs / hands / palms Description Primary Lesions Papule / hyperpigmented Hyperkeratosis [dermquest.com]

Oral retinoids may be helpful in reducing hyperkeratosis secondary to chronic arsenicism. [ncbi.nlm.nih.gov]

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Keratosis Pilaris

Keratosis pilaris (KP) is a common inherited disorder of follicular hyperkeratosis It is characterized by small, folliculocentric keratotic papules that may have surrounding [ncbi.nlm.nih.gov]

Abstract Folliculitis spinulosa decalvans is an uncommon condition characterized by follicular hyperkeratosis, followed by scarring alopecia. [ncbi.nlm.nih.gov]

BACKGROUND: Keratosis pilaris atrophicans defines a group of cutaneous disorders characterized by follicular hyperkeratosis and scarring. [ncbi.nlm.nih.gov]

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Verruca Vulgaris

Histopathologic findings from three skin regions revealed characteristic features of epidermolytic hyperkeratosis, verruca vulgaris, and disseminated superficial porokeratosis [ncbi.nlm.nih.gov]

Microscopic Features: [1] Hyperkeratosis (more keratin - thick stratum corneum) - in "columns"; keratin in separate towers - not a flat thick sheet. [librepathology.org]

LM papillomatous hyperplasia (rete ridges long & curve inward), hyperkeratosis, hypergranulosis, large blood vessels at the dermal-epidermal junction, /-viral changes - perinuclear [librepathology.org]

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Lichen Sclerosus

Criteria evaluated included hyperkeratosis, epidermal atrophy, follicular plugging, basal cell vacuolation, vascular ectasia, hyalinosis, inflammatory infiltrate, dermal edema [ijdpdd.com]

A punch biopsy from an atrophic plaque was performed, and it revealed hyperkeratosis, atrophic epidermis, basal layer vacuolar degeneration, mild lymphocytic infiltration [ncbi.nlm.nih.gov]

Following an incisional biopsy and microscopy, the lesion was shown to be covered by a stratified squamous epithelium showing hyperkeratosis and atrophy. [ncbi.nlm.nih.gov]

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Erythema Palmaris Hereditarium

It is aymptomatic without scaling, hyperkeratosis or hyperidrosis. [lucianoschiazza.it]

The entire family has diffuse hyperkeratosis and hyperkeratosis of all nails affecting both hands and feet symmetrically. [faoj.org]

Hyperkeratosis of the umbilicus and nipple areolae were present, as well as very mild thickening and dryness of the knees and elbows. [genome.jp]

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Ovarian Cyst

[…] little or no hyperkeratosis. [orpha.net]

Histological findings of orthokeratotic hyperkeratosis and acanthosis confirm our diagnosis. [e-ijd.org]

[…] of the distal nails and focal palmoplantar hyperkeratosis. [idoj.in]

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