Hyperkeratotic Plaques: Causes & Reasons

Possible Causes for Hyperkeratotic Plaques

Yellow-brown hyperkeratotic plaques, often associated with mild background erythroderma, develop later, usually in the first months of life. [orpha.net]

plaques on the tongue. [2], [12], [15], [16] Mostly, patients with ichthyosis do not require any modification in dental treatment; however, the dentist should be aware of [ijpd.in]

plaques, ichthyosiform scaling, circular constrictions around fingers and numerous papules in a linear pattern in the arm folds and on the wrists.107 In 2010, a single nucleotide [onlinelibrary.wiley.com]

Palmoplantar Pustulosis

Visual appearance Foot psoriasis, showing hyperkeratosis Presentation Red scaly plaques. Hyperkeratotic areas. Central palm or weight-bearing areas of the soles. [patient.info]

Differential diagnosis Hyperkeratotic eczema. Tinea pedis. Palmoplantar pustulosis (PPP) (see section below). [patient.info]

Zinc-Responsive Necrolytic Acral Erythema

plaques with a rim of dusky erythema, of exclusively acral distribution with a predilection for the lower extremities, and universal association with hepatitis C virus infection [orpha.net]

Figure 3: Clinical picture of well-defined hyperkeratotic, hyperpigmented plaques with violaceous hue on the dorsa of both feet. [idoj.in]

Materials and Methods: Ten patients with characteristic clinical features of distinctive hyperkeratotic plaque in the acral areas, who were resistant to treatment by different [ingentaconnect.com]

Diffuse Palmoplantar Keratoderma

Fig. 1 Yellowish hyperkeratotic plaques on palms. Fig. 2 Hyperkeratosis sparing the arches of feet. [indianpediatrics.net]

We have studied a family with severe, diffuse, nonepidermolytic PPK and verrucous hyperkeratotic plaques over the joints and in flexures and identified a new KRT1 gene mutation [ncbi.nlm.nih.gov]

Hyperkeratotic plaques mimicking knuckle pads were seen on the proximal interphalangeal joints. [e-ijd.org]

Palmoplantar Keratosis

Cutaneous examination revealed thick, hyperkeratotic plaques with underlying erythema on the thenar eminence of both palms and fingers [Figure 1]. [doi.org]

In addition, hyperkeratotic plaques frequently occur on the elbows and knees [ 3, 4 ]. [dermatology.cdlib.org]

plaques around the body orifices, onychodystrophy, and other less common cutaneous and extracutaneous anomalies. [thedoctorsdoctor.com]

Angiokeratoma Circumscriptum

Examination revealed dark brown, hyperkeratotic, indurated, verrucous linear plaques with irregular borders. [e-ijd.org]

Figure 1 Erythematous to hyperkeratotic papules to plaques present over the lateral aspect of dorsum of the left hand. [jewd.eg.net]

Females (3:1) Clinical presentation Violaceous hyperkeratotic plaques on lower limbs Violaceous hyperkeratotic plaques on lower limbs Histopathology Involvement of the subcutaneous [scielo.br]

Papillon Lefevre Disease

[…] of the hands, although there were more slight hyperkeratotic plaques in Case III [Figure 8]. [njcponline.com]

Figure 1: Bilateral, symmetrical hyperkeratotic plaques on the soles. Figure 2: Bilateral, symmetrical hyperkeratotic plaques on the knees. [scitechnol.com]

Knees and elbows may manifest hyperkeratotic plaques in some patients. [visualdx.com]

Pachyonychia Congenita Type 1

Oral cavity revealed white hyperkeratotic plaque over buccal mucosa. [ijdd.in]

[…] papules over the palms Figure 8 Note the massive plantar keratoderma Figure 9 Dorsum of the tongue showing leukokeratosis Figure 10 Photomicrograph of a hyperkeratotic plaque [pubmed.ncbi.nlm.nih.gov]

Oral examination revealed white hyperkeratotic plaque over buccal mucosa. Other mucosa, hair, and dentition were normal. [ijdd.in]

Annular Epidermolytic Ichthyosis

Blistering ceased at puberty, but the hyperkeratotic plaques persisted. [ncbi.nlm.nih.gov]

plaques on the trunk and the proximal extremities. [ncbi.nlm.nih.gov]

A, Hyperkeratotic, lichenified plaque in axilla (with biopsy site) and elbow. Scaly annular plaques on arm (with biopsy site) and trunk. [documents.tips]

Acanthosis Nigricans

We present a case of a 14-year-old male with multiple hyperpigmented, hyperkeratotic plaques on the upper body, axillae, and groin with a segmental distribution following [ncbi.nlm.nih.gov]

Clinically, it manifests as brown, velvety, hyperkeratotic plaques most often found in the axillae, the back of the neck, and other flexural areas.4 The lesions range in severity [jamanetwork.com]

We describe a 9-year-old boy with acute behavioral and cognitive deterioration, combined with cutaneous, diffuse hyperpigmented and hyperkeratotic plaques. [ncbi.nlm.nih.gov]

Bazex Syndrome

Acrokeratosis paraneoplastica of Bazex is rare condition, characterized with scaly hyperkeratotic psoriasiform plaques on acral parts of body (helices, nose, and malar and [ncbi.nlm.nih.gov]

A 66-year-old man presented to the clinic with a 4-week history of painful, edematous, and scaly ears, a condition that was later accompanied by itchy, hyperkeratotic plaques [nejm.org]

[…] psoriasiform plaques on acral parts of body (helices, nose, and malar and acral surfaces), and in later stages propagation to the limbs and trunk.This syndrome is distinct [read.qxmd.com]

Tyrosinemia

Physical examination revealed painful, non-pruritic, hyperkeratotic plaques on the soles, palms and fingertips. [ncbi.nlm.nih.gov]

Type II is caused by a deficiency of tyrosine aminotransferase (TAT), and clinically presents with hyperkeratotic plaques on the hands and soles of the feet and photophobia [genome.jp]

In a few months these lesions evolved into typical hyperkeratotic plaques also involving the palms and soles. [ncbi.nlm.nih.gov]

Familial Primary Localized Cutaneous Amyloidosis

Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. [malacards.org]

Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet [malacards.org]

Penile Intraepithelial Neoplasia

PKMB presents as a thick hyperkeratotic plaque with thick adherent micaceous scaling. [ijstd.org]

Include Erythroplasia of Queyrat (erythematous plaque on the glans and prepuce) and Bowen's Disease (scaly hyperkeratotic plaque, usually on shaft of penis) (image A). [auanet.org]

It presents as a hyperkeratotic plaque over the glans penis, with an overlying thick micaceous scale. [ijstd.org]

Pachyonychia Congenita

A 21-year-old man presented with hypertrophic nail dystrophy and subungual debris of all 20 nails, hyperkeratotic plaques on the heels of both feet, and oral leukokeratosis [ncbi.nlm.nih.gov]

Oral cavity revealed white hyperkeratotic plaque over buccal mucosa. [ijdd.in]

Cutis. 2009 November;84(5):269-271 A 21-year-old man presented with hypertrophic nail dystrophy and subungual debris of all 20 nails, hyperkeratotic plaques on the heels of [mdedge.com]

Confluent and Reticulated Papillomatosis

Physical Examination Hyperpigmented, hyperkeratotic, patches and plaques with scale were present on the neck, mid-back, and sternal area. [randyjacobsmd.com]

It usually presents as hyperkeratotic brown papules that coalesce into plaques with a reticulated periphery on the central trunk of young adults. [ncbi.nlm.nih.gov]

Skin examination revealed brownish, verrucous, hyperkeratotic, 2 to 5 mm papules, which formed confluent patches and plaques with a reticulate network on the interscapular [ncbi.nlm.nih.gov]

Pemphigus Vegetans

plaques in buccal mucosa, and (f) erosions and ulcers with hyperkeratotic plaques in mandibular buccal vestibule Click here to view A diagnostic workup involving mucosal [njcponline.com]

Figure 1: (a, b) hyperkeratotic verrucous, vegetating plaques over (a) abdomen and (b) back Figure 2: Large annular hyperkeratotic verrucous plaque over forearm Figure 3: [journals.lww.com]

She also had hyperkeratotic plaques on the borders of both feet ( Figure 2 ), as well as verrucous paronychia of the 20 nails ( Figure 3 ) with pachyonychia and onychorrhexis [scielo.br]

Bullous Erythroderma Ichthyosiformes

Figure 1: Dirty brown, corrugated, hyperkeratotic plaques over the trunk along with areas of superficial erosion. [ommegaonline.org]

Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. [genecards.org]

[…] verrucous plaques and patchy alopecia over scalpe without any nail and skeletal abnormalities. [idoj.in]

Autosomal Dominant Keratitis

Wart-like hyperkeratotic plaques on an erythematous base, which were initially interpreted as ichthyotic but, in fact, turned out to be ichthyosis-like erythrokeratoderma, [link.springer.com]

A) Keratoderma of the soles B) Rippled hyperkeratotic plaques on the knees; C) Hypotrichosis of the eyelashes and eyebrows; D) Mild vascularizing keratitis; E) Hyperkeratosis [bmcmedgenet.biomedcentral.com]

There was erythrokeratoderma of face and discrete hyperkeratotic hyperpigmented papulo plaque lesions on the body. [idoj.in]

Bloch Sulzberger Syndrome

The second stage is the verrucous, when linear verrucous hyperkeratotic plaques appear with variable duration. [ncbi.nlm.nih.gov]

Palmoplantar Keratoderma of Sybert

In addition, hyperkeratotic plaques frequently occur on the elbows and knees [3, 4]. [escholarship.org]

Hyperkeratotic, erythematous plaques were noted on the elbows and knees. Examination of the hair, nails, and teeth was normal. Figure 1 Figure 2 Laboratory data.— None. [escholarship.org]

Progressive Symmetric Erythrokeratodermia

Symmetric hyperkeratotic plaques with well-defined outlines on the dorsum of the hands. Figure 2. [cyberleninka.org]

Skin lesions are characterized by erythematous, symmetrical, well-defined, hyperkeratotic plaques commonly seen over the elbows, knees, buttocks, face, palms, and soles. [journals.lww.com]

Symmetric hyperkeratotic plaques with erythematous outlines on the elbows and forearms. Figure 4. [cyberleninka.org]

Erythrokeratoderma

Erythrokeratodermas are rare genodermatoses that have characteristic clinical presentations of well-demarcated, hyperkeratotic, and erythematous plaques. [ncbi.nlm.nih.gov]

It presents with symmetric, hyperkeratotic plaques distributed on the extremities, buttocks, and face (1,2). [the-medical-dictionary.com]

plaques consistent with progressive symmetric erythrokeratoderma (PSEK). [jddonline.com]

Erythrokeratodermia Variabilis et Progressiva

Erythema can appear on healthy skin and within hyperkeratotic plaques. [emedicine.medscape.com]

(a and b) Well-defined hyperkeratotic polycyclic plaques over the lower back at 0 week (c) Complete resolution of the lesions after the initiation of oral retinoids at 6 weeks [ncbi.nlm.nih.gov]

It is a rare inherited cornification disorder, manifested by symmetrical hyperkeratotic plaques on an erythematous base generally over the extremities and buttocks, and with [medigraphic.com]

Keratoderma Palmoplantaris Transgrediens

In addition, hyperkeratotic plaques may occur on the elbows and knees. We describe a 44-year-old patient with typical features of Greither’s disease. [karger.com]

In addition, hyperkeratotic plaques frequently occur on the elbows and knees [3, 4]. [escholarship.org]

plaques over the dorsum of the hands and toes, and linear hyperkeratotic lesions over the Achilles tendon areas, ankles, elbows, and knees. [jamanetwork.com]

Pigmented Fungiform Tongue Papillae

Hyperkeratotic Plaques on the Palms and Soles A Red-Brown Plaque on the Nape Hyperpigmented Patches on the Tongue of a Young Girl. Arch. Dermatol. 2009;140:1275–1280. [ncbi.nlm.nih.gov]

Hyperkeratotic Plaques on the Palms and Soles A Red-Brown Plaque on the Nape Hyperpigmented Patches on the Tongue of a Young Girl. Arch. Dermatol. 2009, 140, 1275–1280. [mdpi.com]

Mal de Meleda

Hyperkeratotic plaques on knees and ankles e. Hyperhidrosis f. Slow progression without remission. [ijdvl.com]

[…] sclerodactyly, knuckle pads, hyperkeratotic plaques on the lips and onychogryphosis. [jemds.com]

(A~D) Well-demarcated hyperkeratotic plaque, involving the palms and soles. Note the hyperkeratosis of the dorsa of the hands and feet. [synapse.koreamed.org]

Progressive Palmoplantar Keratoderma of Greither

[41]; consanguineous marriage [45, 46] The dorsal aspects of the finger joints are covered by hyperkeratotic plaques [35] More hyperhidrotic, mild nail changes, and more [ncbi.nlm.nih.gov]

Progressive, well-defined perioral, perianal, and perineal hyperkeratotic plaques are present, as is onychodystrophy. [emedicine.medscape.com]

EKV can be a consideration but the migratory nature of hyperkeratotic (not keratodermic) erythematous rather flat plaques usually distinguishes this particular disorder. [plasticsurgerykey.com]

Ichthyosis Hystrix Type Curth-Macklin

Thick hyperkeratotic plaques involving the nipple and abdomen Verrucous ridged to cobblestoned plaques over (a) knees; (b) hyperkeratotic plaques involving dorsum of hands [ncbi.nlm.nih.gov]

Ichthyosis hystrix Curth-Macklin (IHCM) is characterized by severe fissuring, mutilating palmoplantar keratoderma, and dark hyperkeratotic plaques over joints... [acronymattic.com]

plaques of varying extent. [semanticscholar.org]

Palmoplantar Keratoderma Type Bothnian

Progressive, well-defined perioral, perianal, and perineal hyperkeratotic plaques are present, as is onychodystrophy. [emedicine.medscape.com]