Hyperlaxity: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Hyperlaxity

Mucopolysaccharidosis Type 4

Joint hyperlaxity is accompanied by frequent luxations (hips, knees). [orpha.net]

[…] lower face, an abnormally short neck, knock knees or genu valgum, flat feet, kyphoscoliosis, abnormal development of the growing ends of the long bones (epiphyses), joint hyperlaxity [cags.org.ae]

From the age of 5 to 6 years, hypoplasia of the odontoid vertebra combined with joint hyperlaxity leads to an instability at the level of the first two cervical vertebra, [orpha.net]

Ehlers-Danlos Syndrome Type 4

Several stigmata of connective tissue disorder were also noted on exam, including joint hyperlaxity. [omicsonline.org]

Library of Medicine - PubMed Health Ehlers-Danlos Support UK Ehlers-Danlos Foundation of New Zealand References [ edit ] ↑ Cashin-Garbutt, A; 2014 'Double-Jointed - Joint Hyperlaxity [en.wikibooks.org]

In contrast, we recently reported a syndrome of joint hyperlaxity, easy bruising, pelvic organs prolapses, premature rupture of the membranes and rectal bleeding associated [ojrd.biomedcentral.com]

Rigid Spine Syndrome

Moderate MmD with Hand Involvement (less than 10 % of all affected patients): Characteristic of this subgroup is distal weakness of the upper limbs and hyperlaxity of the [mgz-muenchen.de]

[…] screening in a consanguineous Algerian family in which three children presented in infancy with moderate weakness predominant in axial muscles, pelvic girdle and hands, joint hyperlaxity [archive-ouverte.unige.ch]

Incontrast, joint hyperlaxity in CCD patients has beenseldom reported. [docslide.com.br]

Congenital Muscular Dystrophy with Integrin Alpha-7 Deficiency

Disease] rdfs:label Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity [bio2rdf.org]

[…] a link between muscle fibers and the surrounding matrix Inheritance pattern : recessive (requires mutations in both copies of a gene to produce symptoms) CMD with joint hyperlaxity [mda.org]

Integrin Alpha Nine presents with distal extremity hyperlaxity, hypotonia, scoliosis, proximal contractures, normal to mildly elevated CPK, and normal intelligence. [disabled-world.com]

Congenital Muscular Dystrophy

Ullrich congenital muscular dystrophy (UCMD), due to mutations in the collagen VI genes, is an autosomal recessive form of CMD, commonly associated with distal joints hyperlaxity [ncbi.nlm.nih.gov]

Joint hyperlaxity and skin changes (follicular hyperkeratosis and muscle biopsy scar thinning) were unique to COL6A. [ncbi.nlm.nih.gov]

Fourteen in 15 patients with SSCD, were shown to have COL6A1, COL6A2 or COL6A3 mutations by NGS analysis; all showed marked distal hyperlaxity and normal intelligence but [ncbi.nlm.nih.gov]

Oculo-Palato-Cerebral Syndrome

Skeletal anomalies include pectus excavatum, joint hyperlaxity and kyphoscoliosis. [orpha.net]

Congenital Shoulder Dislocation

Congenital Hyperlaxity : Some athlete always had joint laxity which we call congenital hyperlaxity and makes them more vulnerable for shoulder subluxation/dislocation. [davelessard.wordpress.com]

Athletes may be predisposed to MDI if they have a congenital condition of hyperlaxity (loose joints). [sportsmd.com]

Patients with multidirectional loose shoulders are often also found to have loose joints or hyperlaxity in other areas of the body. [rocmd.com]

Ehlers-Danlos Syndrome Classic-Like Type 1

The aim of which was to provide an overview of hyperlaxity of joints and this edition follows that aim by describing the most recent research and new developments in biochemistry [books.google.com]

In addition, she had atrophic paper scars on the face, elbows, knees, and shins; ecchymoses on the lower legs; and generalized joint hyperlaxity. [ncbi.nlm.nih.gov]

Joint hyperlaxity was limited to the1234 HUMAN MUTATION, Vol. 31, No. 11, 12331239, 2010metacarpophalangeal joints. She presented talipes valgus andplanus. [vdocuments.net]

Hypermobility Syndrome

The major criteria are joint hyperlaxity, skin hyperextensibility, and no evidence of skin or soft tissue fragility. [symptoma.com]

CONCLUSIONS: Significantly lower prolidase activity in patients with BJHS suggests that prolidase may affect the collagen metabolism and cause hyperlaxity. [ncbi.nlm.nih.gov]

Página 191 - Guijo P 1993 Joint hyperlaxity and musculoligamentous lesions: study of a population of homogeneous age, sex and physical exertion. ‎ [books.google.es]

Autosomal Recessive Cutis Laxa Type 1A

ORDO:2962, UMLS_CUI:C0268354 Definition: A cutis laxa characterized by a progeria-like appearance, ophthalmologic abnormalities, large and late-closing fontanel, joint hyperlaxity [informatics.jax.org]

Definition A syndrome characterized by facial dysmorphism with a progeroid appearance, large and late-closing fontanel, cutis laxa, joint hyperlaxity, athetoid movements and [uniprot.org]

Muscular Dystrophy-Dystroglycanopathy Type C7

Congenital muscular dystrophy type 1A Congenital muscular dystrophy type 1B Congenital muscular dystrophy with cerebellar involvement Congenital muscular dystrophy with hyperlaxity [se-atlas.de]

[…] syndrome Osteopetrosis and related disorders Osteopetrosis with renal tubular acidosis Osteopetrosis-hypogammaglobulinemia syndrome Osteoporosis-macrocephaly-blindness-joint hyperlaxity [se-atlas.de]

Patellar Dislocation

In the case of a single high energy injury in a mature non-hyperlax individual the MPFL is likely to be ruptured. This will require reconstruction. [capetownkneesurgery.co.za]

We suggest that this complication is caused by the original underlying pathology such as dysplastic trochlea, abnormal TT-TG, patella alta and hyperlaxity, resulting a greater [ncbi.nlm.nih.gov]

Patellar dislocation usually occurs spontaneously following torsion of a semiflexed knee and is typically the result of underlying biomechanical abnormalities such as hyperlaxity [amboss.com]

Ehlers-Danlos-Syndrome Type 10

Only an iliac osteotomy with or without a varus and derotation femoral osteotomy shows stability in other hyperlaxity syndromes 1, 5. Table 1. [f1000research.com]

Summary The authors present a case of Ehlers-Danlos’ syndrome in its classical form that due to articular and ligamentous hyperlaxity was accompanied by orthopedic complications [archbronconeumol.org]

In contrast, we recently reported a syndrome of joint hyperlaxity, easy bruising, pelvic organs prolapses, premature rupture of the membranes and rectal bleeding associated [ojrd.biomedcentral.com]

Muscular Dystrophy-Dystroglycanopathy Type B6

Hyperlaxity was evident at the wrists, fingers, ankles and toes. [neurologyindia.com]

A new form of congenital muscular dystrophy with joint hyperlaxity maps to 3p23-21. [ncbi.nlm.nih.gov]

Affected individuals may experience hypotonia, contractures, joint hyperlaxity, and scoliosis. [rarediseases.org]

Congenital Merosin-Positive Muscular Dystrophy

Onset is often at birth with congenital proximal contractures and arthrogryposis caused by reduced fetal movements, hypotonia, and early hyperlaxity of distal joints (Figure [academlib.com]

A new form of congenital muscular dystrophy with joint hyperlaxity maps to 3p23-21. [ncbi.nlm.nih.gov]

Integrin Alpha Nine presents with distal extremity hyperlaxity, hypotonia, scoliosis, proximal contractures, normal to mildly elevated CPK, and normal intelligence. [disabled-world.com]

Thoracomelic Dysplasia

Ehlers-Danlos Syndrom Classic Type 2

Autosomal recessive cutis laxa type 2, classic type Autosomal recessive cutis laxa type 2A Autosomal recessive cutis laxa type 2B Basal epidermolysis bullosa simplex Body skin hyperlaxity [se-atlas.de]

Only an iliac osteotomy with or without a varus and derotation femoral osteotomy shows stability in other hyperlaxity syndromes 1, 5. Table 1. [f1000research.com]

They are commonly associated with joint hyperlaxity and dislocation. [hoajonline.com]

Sarcotubular Myopathy

Facial weakness, high-arched palate, ptosis, ophthalmoplegia, joint hyperlaxity, and contractures are common. Benign couse 37. [slideshare.net]

A homozygous microdeletion of chromosome 4q11-12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures. Hum Mutat 2005;26:279-280. [uniklinikum-dresden.de]

1908, Howard coined the term congenital muscular dystrophy (CMD) when he described another infant with similar features. • Ullrich first described the combination of joint hyperlaxity [slideshare.net]

Diastrophic Dysplasia

Joint deformations are severe and can lead to either limitation of joint movement or hyperlaxity. [orpha.net]

Bethlem Myopathy Type 2

The joint hyperlaxity persists and the boy did not develop any joint contracture. [scielo.br]

Resumo: Ullrich congenital muscular dystrophy (UCMD), due to mutations in the collagen VI genes, is an autosomal recessive form of CMD, commonly associated with distal joints hyperlaxity [bases.bireme.br]

Key words: Ullrich congenital muscular dystrophy, congenital muscular dystrophy, joint hyperlaxity, collagen VI, Bethlem myopathy. [scielo.br]

Ablepharon Macrostomia Syndrome

[…] syndrome cranio-facio-fronto-digital SNOMEDCT-BE (macrocephaly, prominent forehead, hypertelorism, exophthalmos), cutis laxa, joint hyperlax / 763320005 SNOMEDCT-BE (disorder [wordscope.com]

[…] mild intellectual disability, short stature, cardiac anomalies, mild dysmorphic features (macrocephaly, prominent forehead, hypertelorism, exophthalmos), cutis laxa, joint hyperlax [wordscope.com]

Cerebro-Facio-Articular Syndrome

Key features of the condition include characteristic facial features, hand abnormalities, moderate to severe intellectual disability, poor muscle tone and joint hyperlaxity [malacards.org]

[…] retardation, hypotonia, dysmorphic facies with telecanthus, epicanthus, broad flattened nose, large inverted W-shaped mouth, malformed ears, finger camptodactyly, and joint hyperlaxity [semanticscholar.org]

[…] epicanthus, broad flattened nose, large inverted W-shaped mouth and malformed ears, malformed extremities such as camptodactyly, clinodactyly, interdigital webbing and joint hyperlaxity [malacards.org]

Congenital Muscular Dystrophy Type Ullrich

Ullrich congenital muscular dystrophy (UCMD), due to mutations in the collagen VI genes, is an autosomal recessive form of CMD, commonly associated with distal joints hyperlaxity [ncbi.nlm.nih.gov]

BACKGROUND: COL6 gene mutations are associated with Ullrich congenital muscular dystrophy (UCMD), which is clinically characterized by muscle weakness from early infancy, hyperlaxity [ncbi.nlm.nih.gov]

Ullrich congenital muscular dystrophy (UCMD), a frequently severe disorder characterized by congenital muscle weakness with joint contractures and coexisting distal joint hyperlaxity [ncbi.nlm.nih.gov]

Pashayan Syndrome

Malformations of the extremities can include camptodactyly, clinodactyly, interdigital webbing, and joint hyperlaxity. [accessanesthesiology.mhmedical.com]

epicanthus, broad flattened nose, large inverted W-shaped mouth and malformed ears), malformed extremities (camptodactyly, clinodactyly, interdigital webbing and joint hyperlaxity [pubmed.ncbi.nlm.nih.gov]

[…] had bilateral auricular hypoplasia, camptodactyly of the third and fifth fingers with axially orientated clinodactyly of all five fingers, interdigital webbing and joint hyperlaxity [nature.com]

Elastoderma

Some cases have been treated with surgical excision (removal of affected skin), but hyperlaxity of skin often returns following the surgery. [malacards.org]

Some cases have been treated with surgical excision (removal of affected skin), but hyperlaxity of skin often returns following the surgery. [1] [2] [3] Last updated: 8/4/ [rarediseases.info.nih.gov]

However, hyperlaxity of skin often returns following the surgery. [1] [2] [3] Last updated: 8/4/2015 These resources provide more information about this condition or associated [rarediseases.info.nih.gov]

Bethlem Myopathy

Ullrich congenital muscular dystrophy (UCMD), due to mutations in the collagen VI genes, is an autosomal recessive form of CMD, commonly associated with distal joints hyperlaxity [ncbi.nlm.nih.gov]

The joint hyperlaxity persists and the boy did not develop any joint contracture. [scielo.br]

UCMD is characterized by early-onset weakness, associated with pronounced distal joint hyperlaxity and the early onset or early progression of more proximal contractures. [ncbi.nlm.nih.gov]

Ehlers-Danlos Syndrome Periodontitis Type 2

Definition A form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity [uniprot.org]

Muscular Dystrophy-Dystroglycanopathy Type A6

Duquette et al. a .: A new form of congenital muscular dystrophy with joint hyperlaxity maps to 3p23-21. In: Brain: a journal of neurology. [de.zxc.wiki]

Ullrich first described the combination of joint hyperlaxity and proximal contractures in 1930 in the German literature; this was the first case of what is now known as Ullrich [emedicine.medscape.com]

[…] alpha-7 Congenital muscular dystrophy with familial epidermolysis bullosa simplex autosomal recessive 226670 PLEC1 8q24.3 Plectine Congenital muscular dystrophy with joint hyperlaxity [de.zxc.wiki]

De Hauwere Syndrome

Short stature and hyperlaxity of joints later leading to severe joint pain were noted. [semanticscholar.org]

Fibular Dimelia-Diplopodia Syndrome

[…] edematous papules/milium Follicular/vermiculata atrophoderma Freezing lesions Furuncle/cutaneous abscess/hidrosadenitis suppurativa Hairy patch Hyperelastic skin/cutaneous hyperlaxity [readbag.com]

[…] www.orphanet.net/ 31 of 39 Thesaurus of Clinical Signs and Symptoms Anomalies of cartilages, joints and periarticular tissue (continued) Hyperextensible joints/articular hyperlaxity [readbag.com]