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1,443 Possible Causes for Hyperlipidemia Type 5, Patient Appears Chronically Ill, Progressive Polyneuropathy

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    BACKGROUND: Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the ninth leading cause of death related to its complications. Although the rate of vascular[…][ncbi.nlm.nih.gov]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[ncbi.nlm.nih.gov] […] in months; LFU, last follow-up; DADS, distal acquired demyelinating symmetric neuropathy; CIDP, chronic inflammatory demyelinating polyneuropathy; SMM, smoldering multiple[doi.org]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) also may be associated with Waldenström macroglobulinemia.[emedicine.medscape.com]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[ncbi.nlm.nih.gov]

    Missing: Hyperlipidemia Type 5
  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[doi.org] Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis.[circ.ahajournals.org]

    Missing: Hyperlipidemia Type 5
  • Myeloma-associated Amyloidosis

    The peripheral neuropathy of MGUS is classically bilateral, peripheral and sensory with electrophysiologic studies showing a demyelinating pattern; and in patients with progressive[hematology.org] […] relationship between MGUS and peripheral neuropathy is supported by association of peripheral neuropathy with other plasma cell dyscrasias including WM, MM, AL amyloid and POEMS (polyneuropathy[hematology.org]

    Missing: Hyperlipidemia Type 5
  • Diabetic Nephropathy

    […] from microalbuminuria to macroalbuminuria, the proportion of individuals with peripheral symmetric polyneuropathy increased progressively in our patients (67-85%) (p 0.001[sjkdt.org] Ann N Y Acad Sci 1084 : 89 –117, 2006 Skundric DS, Lisak RP: Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: From glucose metabolism[doi.org] In fact majority of the patients from CKD stages II to V (74-100%) had peripheral symmetric polyneuropathy.[sjkdt.org]

    Missing: Hyperlipidemia Type 5
  • Addison's Disease

    This disease is milder and progresses more slowly than adrenoleukodystrophy.[pedclerk.bsd.uchicago.edu] Adrenomyeloneuropathy begins in adolescence or early adulthood with weakness, spasticity, and distal polyneuropathy.[pedclerk.bsd.uchicago.edu] Adrenoleukodystrophy begins in infancy or childhood with weakness and spasticity and progresses to dementia, blindness and quadriparesis.[pedclerk.bsd.uchicago.edu]

    Missing: Hyperlipidemia Type 5
  • Spinal Pachymeningitis

    Idiopathic hypertrophic cranial pachymeningitis causing progressive polyneuropathies in a child. Eur J Paediatr Neurol 2008; 12: 144-7.[medigraphic.com]

    Missing: Hyperlipidemia Type 5

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