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2,234 Possible Causes for Hyperpigmentation

  • Vitamin B12 Deficiency

    Hyperpigmentation as the first presentation of Vitamin B12 deficiency is rare.[] Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas.[] […] are presenting an interesting case of a 4 year old boy who was being treated for Vitamin B 12 deficiency on the basis of history of delayed milestone, abdominal pain and hyperpigmentation[]

  • Hemochromatosis

    External genital hyperpigmentation was seen in one third of patients, and one fifth had hyperpigmentation of flexural folds, scars, and nipple areolae.[] PubMed was used to search the following terms: hemochromatosis, hereditary, hyperpigmentation, hypopigmentation, keratosis, melanin, seborrheic, siderosis.[] Hyperpigmentation of the oral mucosa was found in 15-20% of patients.[]

  • Cronkhite-Canada Syndrome

    A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy.[] The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and[] Cronkhite-Canada syndrome is characterized by generalized gastrointestinal polyps associated with hyperpigmentation, hair loss, and onycholysis.[]

  • Skin Cancer

    Prior to the laser sessions, these scars demonstrated hypopigmentation, hyperpigmentation, neovascularization, or diminished pore structures compared to the surrounding skin[] Hyperpigmentation has been treated with dermabrasion and laser resurfacing. Graft Failure Skin grafting may be unsuccessful for numerous reasons.[]

  • Acanthosis Nigricans

    He was referred to our polyclinic by endocrinologist because of progressive hyperpigmentation marked on his face and oral mucosa.[] This is part II of a two-part article on hyperpigmentation in adults.[] It is characterized by proliferation of keratinocytes resulting in papillomatous change and hyperpigmentation of the skin and multiple confluent warty or verrucous lesions[]

  • Adenoma

    […] cardiomegaly, heat intolerance, weight gain ACTH ( 20%) Cushing's disease : central obesity (moon facies, buffalo hump), thin skin with striae, hirsutism Nelson's syndrome : hyperpigmentation[] […] complex [ edit ] Carney complex (CNC), also known as LAMB syndrome [20] and NAME syndrome [20] is an autosomal dominant condition comprising myxomas of the heart and skin, hyperpigmentation[]

  • Hyperthyroidism

    Reactive hyperpigmentation of the skin and mucous membranes may be found in Addison's disease and hyperthyroidism.[] Tachycardia, irregular pulse (in atrial fibrillation), dyspnea, orthopnea and peripheral edema (in heart failure) Cutaneous Onycholysis (Plummer nails), patchy or generalized hyperpigmentation[] […] acropachy, an uncommon sign, is the clubbing of fingers and toes with soft-tissue swelling of the hands and feet. 19 Other skin manifestations of Graves disease include patchy hyperpigmentation[]

  • Adrenal Insufficiency

    PATIENT AND METHODS: The patient was born with hyperpigmentation, micropenis, penoscrotal hypospadias, and mild cryptorchidism.[] This situation may be associated with symptoms suggestive of chronic adrenal insufficiency such as hyperpigmentation, salt craving, and association with autoimmune diseases[] Addison disease was identified due to hyperpigmentation of lips and gums present from early childhood.[]

  • Addison's Disease

    We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and[] Herein this case report, we focus on the subtle findings of diffuse hyperpigmentation and intermittent but repetitive "flu-like" symptoms in two patients to correctly identify[] The physical examination was completely normal except for muscle weakness, hyperpigmentation on labial mucosa and skin in a patient.[]

  • Malignant Melanoma

    Kundu, Facial hyperpigmentation: causes and treatment, British Journal of Dermatology, 169, s3, (41-56), (2013). Adèle C. Green, Catherine M. Olsen and Linda J.[]

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