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149 Possible Causes for Hyperpigmentation, Malar Rash, Sclerodactyly, Sjogren's Syndrome

  • Diffuse Scleroderma

    Skin can breakdown and discharge chalky material (calcium) Salt and pepper dyspigmentation ( hyperpigmentation and hypopigmentation ) Pruritus Rarer cutaneous features Morphoea[dermnetnz.org] Eyes, ears, nose, and throat This manifests as Sicca syndrome, also called Sjogren's syndrome, which classically combines dry eyes, dry mouth, and another disease of connective[sclerodermasociety.co.uk] , and telangiectasia (CREST) syndrome (disorder) Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome (disorder) Crest syndrome[icd9data.com] During the subsequent 6 months, the patient developed lower limb oedema, which progressed to the hands and face, coupled with generalized pain and hyperpigmentation of skin[doi.org]

  • Dermatomyositis

    12 (44.4%) Malar rash 14 (51.9%) Gottron’s sign 23 (85.2%) V Sign 16 (59.3%) Shawl Sign 15 (55.6%) Nail-bed erythema 17 (63.0%) Dilated capillary loops 14 (51.9%) Holster[acrabstracts.org] Poikiloderma vasculare atrophicans refers to mottled hyperpigmentation and hypopigmentation of the skin with in-between telangiectases and areas of atrophy and is considered[ncbi.nlm.nih.gov] syndrome). [3] Dalakas MC, Hohlfeld R.[bestpractice.bmj.com] […] lupus erythematosus, Sjögren's syndrome, polyarteritis nodosa and mixed connective tissue disease' , and these patients may present with p' olyarthritis, sicca syndrome, sclerodactyly[physio-pedia.com]

  • Porphyria Cutanea Tarda

    Abstract A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed[ncbi.nlm.nih.gov] Other characteristic signs of PCT include dark or reddish urine, general skin fragility, hyperpigmentation, and hypertrichosis.[symptoma.com] We report a case of porphyria cutanea tarda associated with primary sjogren's syndrome.[ncbi.nlm.nih.gov] Our patient had sclerodactyly with fingertip ulcerations as well as the classic facial features and skin tightness of PSS.[ncbi.nlm.nih.gov]

  • Systemic Scleroderma

    […] severe type of systemic scleroderma with hyperpigmentation, especially male and older patients, and in unexposed portions of the female group without hyperpigmentation.[ncbi.nlm.nih.gov] syndrome (Sjs), dermatomyositis (DM), rheumatoid arthritis (RA), and dermatitis (DE) (109 cases) as a control.[ncbi.nlm.nih.gov] ., 1) sclerodactyly, 2) digital pitting scars of fingertips or loss of substance of the distal finger pad, and 3) bilateral basilar pulmonary fibrosis.[ncbi.nlm.nih.gov] , and telangiectasia (CREST) syndrome (disorder) Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome (disorder) Crest syndrome[icd9data.com]

    Missing: Malar Rash
  • Mixed Connective Tissue Disease

    On physical exam, there is a malar rash, sclerodactyly, and joint tenderness.[medbullets.com] She had generalized hyperpigmentation. Tightening of face was observed in eight patients of MCTD and all of them had tightening of fingers.[e-ijd.org] syndrome (p 0.78), scleroderma-pattern in the nailfold capillaroscopy (p 1.0), lymphopenia #1000/mm³ on two or more occasions (p 1.0), hypergammaglobulinemia 1.6 g/d (p 0.60[ncbi.nlm.nih.gov] Main symptoms of the disease are polyarthritis, hand oedema, Raynaud's phenomenon, sclerodactyly, myositis and oesophageal hypomobility.[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    Clinical features include 12 : pruritus (often the first symptom) jaundice skin hyperpigmentation, especially of arms and trunk xanthomata and xanthelasma due to hypercholesterolemia[radiopaedia.org] syndrome and Hashimoto's thyroiditis.[ncbi.nlm.nih.gov] […] known to have a strong association with other autoimmune–mediated conditions such as scleroderma, telangiectasia syndrome, esophageal motility disorder, celiac disease, sclerodactyly[symptoma.com] Hanot cirrhosis - a condition characterized by obstructive jaundice with hyperlipemia, pruritus, and hyperpigmentation of the skin. Synonym(s): primary biliary cirrhosis[medical-dictionary.thefreedictionary.com]

    Missing: Malar Rash
  • Celiac Disease

    After three weeks she developed other symptoms such as arthralgias, malar rash, being finally diagnosed with SLE and possible autoimmune hepatitis.[ncbi.nlm.nih.gov] […] symmetrical, grouped polymorphic lesions consisting of erythema, urticarial plaques, papules, herpetiform vesiculae, and blisters followed by erosions, excoriations, and hyperpigmentation[doi.org] Sjogren's syndrome (a disorder that causes insufficient moisture production by the glands). Cleveland Clinic News & More Cleveland Clinic News & More[my.clevelandclinic.org] Celiac disease and markers of celiac disease latency in patients with primary Sjogren’s syndrome. Am J Gastroenterol. 1990;94:1042–6. Google Scholar 15.[doi.org]

    Missing: Sclerodactyly
  • Childhood Dermatomyositis

    About 40% of children also have a prominent erythematous malar rash. This rash can be ulcerative, cross the nasolabial folds, and extend onto the forehead.[clinicalgate.com] Although the skin rashes frequently fade completely, they may be followed by brownish discolorations (hyperpigmentation) of the skin, atrophy, scarring, and/or loss of color[rarediseases.org] Other conditions, such as lupus, rheumatoid arthritis, scleroderma and Sjogren's syndrome, can occur with dermatomyositis (overlap syndromes). Cardiovascular disease.[mayoclinic.org] […] lupus erythematosus, Sjögren's syndrome, polyarteritis nodosa and mixed connective tissue disease' , and these patients may present with p' olyarthritis, sicca syndrome, sclerodactyly[physio-pedia.com]

  • Muckle Wells Syndrome

    OR PAIN: Rash (malar, discoid) Arthritis Soft tissue/serositis Hematologic disorder Oral/nasopharyngeal ulcers Renal dz, Raynaud pheonomenon Photensensitivty, Positive VDLR[quizlet.com] Describe six cases of sclerodermoid lesions, with hyperpigmentation, sclerosis and hypertrichosis 4 .[scielo.br] syndrome , unspecified Sjˆgren's syndrome ; Sjögren's syndrome ; Sjogrens syndrome ICD-10-CM Diagnosis Code M35.00 Sicca syndrome, unspecified 2016 2017 2018 2019 Billable[icd10data.com] […] increased intracranial pressure due to chronic aseptic meningitis of mild intensity, demyelinating lesions, 14 cutaneous lesions (aphthosis, ichthyosis, hypertrichosis, and hyperpigmentation[revistanefrologia.com]

  • Limited Cutaneous Systemic Sclerosis

    […] report a 56-year-old Korean woman with porphyria cutanea tarda (PCT), showing multiple scarring bullae and hypertrichosis on sun-exposed areas of skin with postinflammatory hyperpigmentation[ncbi.nlm.nih.gov] […] in progression to SS, complicated with Sjogren's syndrome.[ncbi.nlm.nih.gov] Abstract An 88-year-old woman with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias) presented with hyperglycemia[ncbi.nlm.nih.gov] […] pruritus in the early stages Oral manifestations of systemic sclerosis Skin findings of systemic scleroderma -Beak like nose -Shiny skin -Taut lips -Salt and pepper hypo/hyperpigmentation[quizlet.com]

    Missing: Malar Rash

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