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3,367 Possible Causes for Hyperpigmentation, Onset of Symptoms in the Fourth to Sixth Decade of Life, Xerostomia

  • Hemochromatosis

    External genital hyperpigmentation was seen in one third of patients, and one fifth had hyperpigmentation of flexural folds, scars, and nipple areolae.[emedicine.com] PubMed was used to search the following terms: hemochromatosis, hereditary, hyperpigmentation, hypopigmentation, keratosis, melanin, seborrheic, siderosis.[ncbi.nlm.nih.gov] Hyperpigmentation of the oral mucosa was found in 15-20% of patients.[emedicine.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Systemic Scleroderma

    […] severe type of systemic scleroderma with hyperpigmentation, especially male and older patients, and in unexposed portions of the female group without hyperpigmentation.[ncbi.nlm.nih.gov] (SSc) is an autoimmune disease that affects connective tissue, resulting in hardening skin, reduced vascular perfusion, gingival fibrosis, enlarged periodontal ligament, xerostomia[ncbi.nlm.nih.gov] SSc patients complained more frequently (78.8%) of oral symptoms (Xerostomia, dysgeusia, dysphagia and stomatodynia) than controls (28.7%) (χ² 40.23 p 0.001).[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Diffuse Scleroderma

    Skin can breakdown and discharge chalky material (calcium) Salt and pepper dyspigmentation ( hyperpigmentation and hypopigmentation ) Pruritus Rarer cutaneous features Morphoea[dermnetnz.org] Muscle weakness Muscular weakness 0001324 Osteolysis Breakdown of bone 0002797 Pulmonary fibrosis 0002206 Skin ulcer Open skin sore 0200042 Telangiectasia of the skin 0100585 Xerostomia[rarediseases.info.nih.gov] During the subsequent 6 months, the patient developed lower limb oedema, which progressed to the hands and face, coupled with generalized pain and hyperpigmentation of skin[doi.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Primary Biliary Cirrhosis

    Clinical features include 12 : pruritus (often the first symptom) jaundice skin hyperpigmentation, especially of arms and trunk xanthomata and xanthelasma due to hypercholesterolemia[radiopaedia.org] She was 38 years old and was admitted to our hospital for generalized pruritus, xerostomia, xerophthalmia, fatigue, and reticulonodular changes on her chest X-ray.[ncbi.nlm.nih.gov] Hanot cirrhosis - a condition characterized by obstructive jaundice with hyperlipemia, pruritus, and hyperpigmentation of the skin. Synonym(s): primary biliary cirrhosis[medical-dictionary.thefreedictionary.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Cronkhite-Canada Syndrome

    A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy.[ncbi.nlm.nih.gov] The courses of this syndrome could be classified into five types according to clinical symptoms; diarrhea, taste disturbance, xerostomia, abdominal pain and alopecia.[e-ce.org] The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Oral Candidiasis

    The four commonest lesions were oral candidiasis (24.9%, CI   20.6-29.7%), melanotic hyperpigmentation (17.3%, CI   13.7-21.7%), kaposi sarcoma (9.3%, CI   6.6-12.8%) and[ncbi.nlm.nih.gov] In patients with T1D and neuropathy, more cases of xerostomia and decreased salivary flow were reported.[dentalcare.com] […] application of topical corticosteroids, and persistent swelling may respond to intralesional injection of triamcinolone acetonide (Kenalog). 16 – 18 CHANGES IN PIGMENTATION Hyperpigmentation[aafp.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Acne Vulgaris

    Post-inflammatory hyperpigmentation after acne can be as troublesome as the acne itself.[ncbi.nlm.nih.gov] Among the numerous documented adverse effects, most common are xerostomia and cheilitis.[ncbi.nlm.nih.gov] The most common side effects of oral isotretinoin were xerostomia and cheilitis.[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Acute Renal Failure

    […] dry eyes dry mouth If you have chronic cholangitis for a long time, you may have: pain in the upper right side night sweats swollen feet and ankles darkening of the skin (hyperpigmentation[healthline.com] Korman -- Urticaria, drug hypersensitivity rashes, nodules and tumors, and atrophic diseases / Madeleine Duvic -- Infectious, hyperpigmentation and hypopigmentation, regional[worldcat.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Sjögren Syndrome

    A 14-year-old adolescent girl with Sjögren syndrome with painful unilateral swelling of the knee and hyperpigmentation of the overlying skin.[emedicine.medscape.com] Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are[ncbi.nlm.nih.gov] No new flares occurred and the skin lesions healed spontaneously without hypo-/hyperpigmentation or scarring. 2, 10 Blood samples showed leucocytes at 120 10 12 /l—normal[doi.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Skin Cancer

    Prior to the laser sessions, these scars demonstrated hypopigmentation, hyperpigmentation, neovascularization, or diminished pore structures compared to the surrounding skin[ncbi.nlm.nih.gov] Dry mouth ( xerostomia ) and dry eyes ( xerophthalmia ) can become irritating long-term problems and severely reduce the patient's quality of life.[en.wikipedia.org] Hyperpigmentation has been treated with dermabrasion and laser resurfacing. Graft Failure Skin grafting may be unsuccessful for numerous reasons.[web.archive.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life

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