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572 Possible Causes for Hyperpigmentation, Peripheral Motor Neuropathy

  • Acute Hepatic Porphyria

    Secondary infections can cause areas of hypo- or hyperpigmentation or sclerodermatous changes and may result in the development of alopecia at sites of repeated skin damage[mayomedicallaboratories.com] neuropathy (patchy numbness and paresthesias), Proximal motor weakness (usually starting in upper extremities which can progress to include respiratory impairment and death[house.wikia.com] […] manifestations Increased fragility of sun-exposed skin blistering and impaired healing ( blistering photosensitivity ) Healing results in scarring and milia formation Hypertrichosis Hyperpigmentation[amboss.com]

  • Acute Intermittent Porphyria

    The affected areas of skin also tend to be fragile and show hyperpigmentation (excess pigment) and hypertrichosis (excess hair).[medicinenet.com] motor neuropathy.[bestpractice.bmj.com] A 45-year-old man with end-stage renal disease due to polycystic kidney disease was admitted to the hospital because of recurrent abdominal pain, progressive peripheral motor[ncbi.nlm.nih.gov]

  • Variegate Porphyria

    It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances.[uniprot.org] Respiratory paralysis 9-20 Preceded by progressive peripheral motor neuropathy and paresis.[clinicaladvisor.com] We present the case of two sisters showing cutaneous signs typical of PCT: blisters, photosensitivity, hyperpigmentation, hypertrichosis, cutaneous fragility, and no acute[porphyria.eu]

  • Porphyria

    Symptoms are: blisters on areas of the skin exposed to the sun such as the face, arms, and hands followed by crusting and scarring; hyperpigmentation; increased hair growth[publichealth.va.gov] Acute attacks occur mainly in adults and comprise severe abdominal pain, nausea, vomiting, autonomic disturbance, central nervous system involvement and peripheral motor neuropathy[ncbi.nlm.nih.gov] The affected areas of skin also tend to be fragile and show hyperpigmentation (excess pigment) and hypertrichosis (excess hair).[medicinenet.com]

  • Malignant Melanoma

    Kundu, Facial hyperpigmentation: causes and treatment, British Journal of Dermatology, 169, s3, (41-56), (2013). Adèle C. Green, Catherine M. Olsen and Linda J.[doi.org] Each of these AEs led to treatment discontinuation, and the one reported case of peripheral motor neuropathy was irreversible.[cancer.gov] Other treatment-related neurologic AEs of grade 3 or 4 were brain edema (2 patients [2%]), intracranial hemorrhage (1 patient [1%]), peripheral motor neuropathy (1 patient[cancer.gov]

  • Celiac Disease

    […] symmetrical, grouped polymorphic lesions consisting of erythema, urticarial plaques, papules, herpetiform vesiculae, and blisters followed by erosions, excoriations, and hyperpigmentation[dx.doi.org] The commonest type of peripheral neuropathy we encountered is sensorimotor axonal (26) followed by mononeuropathy multiplex (15), pure motor neuropathy (10), small fibre neuropathy[dx.doi.org] Prospective screening of 101 patients with idiopathic peripheral neuropathy has shown the prevalence of gluten sensitivity to be 40% (unpublished data).[dx.doi.org]

  • Hereditary Coproporphyria

    […] the following symptoms (on exposure to direct sunlight): Skin gets inflamed with burning sensation Blister formation can take place Over time, the skin becomes weak Skin hyperpigmentation[dovemed.com] Peripheral neuropathies are predominantly motor neuropathies and can mimic Guillain-Barré syndrome.[emedicine.medscape.com] […] generally appears in middle-age -Enzyme defect: Uroporphyrinogen decarboxylase -Fragile skin, blister formation, thickening, and scarring of sun-exposed skin, and areas of hyperpigmentation[quizlet.com]

  • Discoid Lupus Erythematosus

    The dyspigmentation of older lesions often presents as central hypopigmentation and peripheral hyperpigmentation.[dermnet.com] Organic neurologic disturbances produce behavioral aberrations and frank psychosis in some patients; in a few others, there are peripheral neuropathies, motor weakness, and[medical-dictionary.thefreedictionary.com] Over time, lesions slowly expand, producing areas of peripheral inflammation or hyperpigmentation, leaving a central region of scarring with telangiectasia and hypopigmentation[bestpractice.bmj.com]

  • Cutaneous T-Cell Lymphoma

    Patients also can present with changes to their nails, hyperpigmentation, alopecia, palmoplantar keratoderma, ectropion, and hepatosplenomegaly.[ncbi.nlm.nih.gov] In these studies, the most frequent AE was peripheral neuropathy.[e-ijd.org] The lesions spontaneously resolve in 4-6 weeks, leaving hyperpigmentation or atrophic scars.[emedicine.medscape.com]

  • Xeroderma Pigmentosum

    Besides the basal cell carcinomas, the background hyperpigmentation and keratotic papules also cleared, and the skin texture improved.[ncbi.nlm.nih.gov] Points were allocated for: Peripheral (motor or sensory) neuropathy (1 point) Cerebellar signs (1 point) Sensorineural hearing loss (1 point) Impaired cognition (1 point)[pnas.org] On general examination, there was patchy hyperpigmentation of the exposed areas of skin suggestive of XP.[ncbi.nlm.nih.gov]

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