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572 Possible Causes for Hyperpigmentation, Peripheral Motor Neuropathy

  • Acute Hepatic Porphyria

    Secondary infections can cause areas of hypo- or hyperpigmentation or sclerodermatous changes and may result in the development of alopecia at sites of repeated skin damage[] neuropathy (patchy numbness and paresthesias), Proximal motor weakness (usually starting in upper extremities which can progress to include respiratory impairment and death[] […] manifestations Increased fragility of sun-exposed skin blistering and impaired healing ( blistering photosensitivity ) Healing results in scarring and milia formation Hypertrichosis Hyperpigmentation[]

  • Acute Intermittent Porphyria

    The affected areas of skin also tend to be fragile and show hyperpigmentation (excess pigment) and hypertrichosis (excess hair).[] motor neuropathy.[] A 45-year-old man with end-stage renal disease due to polycystic kidney disease was admitted to the hospital because of recurrent abdominal pain, progressive peripheral motor[]

  • Variegate Porphyria

    It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances.[] Respiratory paralysis 9-20 Preceded by progressive peripheral motor neuropathy and paresis.[] We present the case of two sisters showing cutaneous signs typical of PCT: blisters, photosensitivity, hyperpigmentation, hypertrichosis, cutaneous fragility, and no acute[]

  • Porphyria

    Symptoms are: blisters on areas of the skin exposed to the sun such as the face, arms, and hands followed by crusting and scarring; hyperpigmentation; increased hair growth[] Acute attacks occur mainly in adults and comprise severe abdominal pain, nausea, vomiting, autonomic disturbance, central nervous system involvement and peripheral motor neuropathy[] The affected areas of skin also tend to be fragile and show hyperpigmentation (excess pigment) and hypertrichosis (excess hair).[]

  • Malignant Melanoma

    Kundu, Facial hyperpigmentation: causes and treatment, British Journal of Dermatology, 169, s3, (41-56), (2013). Adèle C. Green, Catherine M. Olsen and Linda J.[] Each of these AEs led to treatment discontinuation, and the one reported case of peripheral motor neuropathy was irreversible.[] Other treatment-related neurologic AEs of grade 3 or 4 were brain edema (2 patients [2%]), intracranial hemorrhage (1 patient [1%]), peripheral motor neuropathy (1 patient[]

  • Celiac Disease

    […] symmetrical, grouped polymorphic lesions consisting of erythema, urticarial plaques, papules, herpetiform vesiculae, and blisters followed by erosions, excoriations, and hyperpigmentation[] The commonest type of peripheral neuropathy we encountered is sensorimotor axonal (26) followed by mononeuropathy multiplex (15), pure motor neuropathy (10), small fibre neuropathy[] Prospective screening of 101 patients with idiopathic peripheral neuropathy has shown the prevalence of gluten sensitivity to be 40% (unpublished data).[]

  • Hereditary Coproporphyria

    […] the following symptoms (on exposure to direct sunlight): Skin gets inflamed with burning sensation Blister formation can take place Over time, the skin becomes weak Skin hyperpigmentation[] Peripheral neuropathies are predominantly motor neuropathies and can mimic Guillain-Barré syndrome.[] […] generally appears in middle-age -Enzyme defect: Uroporphyrinogen decarboxylase -Fragile skin, blister formation, thickening, and scarring of sun-exposed skin, and areas of hyperpigmentation[]

  • Discoid Lupus Erythematosus

    The dyspigmentation of older lesions often presents as central hypopigmentation and peripheral hyperpigmentation.[] Organic neurologic disturbances produce behavioral aberrations and frank psychosis in some patients; in a few others, there are peripheral neuropathies, motor weakness, and[] Over time, lesions slowly expand, producing areas of peripheral inflammation or hyperpigmentation, leaving a central region of scarring with telangiectasia and hypopigmentation[]

  • Cutaneous T-Cell Lymphoma

    Patients also can present with changes to their nails, hyperpigmentation, alopecia, palmoplantar keratoderma, ectropion, and hepatosplenomegaly.[] In these studies, the most frequent AE was peripheral neuropathy.[] The lesions spontaneously resolve in 4-6 weeks, leaving hyperpigmentation or atrophic scars.[]

  • Xeroderma Pigmentosum

    Besides the basal cell carcinomas, the background hyperpigmentation and keratotic papules also cleared, and the skin texture improved.[] Points were allocated for: Peripheral (motor or sensory) neuropathy (1 point) Cerebellar signs (1 point) Sensorineural hearing loss (1 point) Impaired cognition (1 point)[] On general examination, there was patchy hyperpigmentation of the exposed areas of skin suggestive of XP.[]

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